A5012373424- Radioactive element chemistry and processing
- Occupational Health and Performance
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Shoulder Injury and Treatment
- Microbial Community Ecology and Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Musculoskeletal pain and rehabilitation
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Trauma and Emergency Care Studies
- Sports injuries and prevention
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Ultrasound in Clinical Applications
- Cancer survivorship and care
- Geochemistry and Geologic Mapping
- Cardiovascular Function and Risk Factors
- Groundwater flow and contamination studies
- Histone Deacetylase Inhibitors Research
- Aortic Disease and Treatment Approaches
- COVID-19 and healthcare impacts
- Genetic Associations and Epidemiology
U.S. Army Research Institute of Environmental Medicine
2021-2024
University of Tennessee at Knoxville
2019-2024
MGH Institute of Health Professions
2022-2024
St Bartholomew's Hospital
2020-2024
Foghorn Therapeutics (United States)
2023-2024
United States Army
2021-2023
Boston Medical Center
2019-2023
Boston University
2019-2023
Manchester Academic Health Science Centre
2020-2023
University of Manchester
2020
Abstract Background The newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, other aquifer environments. Recently increasing attention paid this diverse including > 20 candidate phyla (a large part of the phylum radiation, CPR) because it refreshed our view tree life. However, adaptive traits contributing its prevalence are still not well known. Results Here, we investigated genomic...
Human casualties related to rapid-onset natural hazards are usually proportional the number of people directly exposed. Yet population mobility makes  exposure difficult assess due temporal and spatial  variability. Population exposure is a crucial dimension risk, often dynamics overlooked in disaster risk assessment subsequent management. Here, we quantify how Aotearoa New Zealand changes across multiple highly resolved scales dynamic observe significant influence it has...
Abstract The paralog lysine acetyltransferases CREB binding protein (CBP) and E1A P300 (EP300) function as transcriptional coactivators that regulate diverse cellular programs. Mutations in CBP EP300 have been implicated the biology of various cancer types. bidirectional synthetic lethal relationship between these paralogs tumor cells highlights a therapeutic opportunity targeting selectively EP300-mutant cancers. We previously demonstrated our selective degraders potent antiproliferative...
The processing of sediment to accurately characterize the spatially-resolved depth profiles geophysical and geochemical properties along with signatures microbial density activity remains a challenge especially in complex contaminated areas. This study processed cores from two boreholes background core sediments surrounding groundwater. Fresh were compared by capture changes structure, minerals, biomass, pore water geochemistry terms major trace elements including pollutants, cations,...
The rhythm of music can entrain neurons in motor cortex by way direct connections between auditory and brain regions.We sought to automate an individualized progressive music-based, walking rehabilitation program using real-time sensor data combination with decision algorithms.A music-based digital therapeutic was developed maintain high sound quality while modulating, real-time, the tempo (ie, beats per minute, or bpm) based on a user's ability progress faster cadences in-sync progression...
Objectives To determine the level of narrowest plane (neo‐annulus) a surgical heart valve (SHV), which could be used for sizing and securing transcatheter (THV) during valve‐in‐valve (VIV) procedure define its relationship with fluoroscopic markers SHV. Background In native aortic valve, annulus is as reference deployment THV it provides dimension to securely anchor THV. However, different models SHV that are currently treated by VIV remains unknown. Methods We studied 13 SHVs from all major...
Abstract E1A binding protein (EP300) and CREB (CBP) are paralog histone acetyltransferases involved in many cellular processes via their activity as transcriptional co-activators. Dysregulation of one or both proteins has been implicated various cancers, functional genomic screens have demonstrated a bidirectional synthetic lethal relationship between the two genes tumor cells. Due to high homology EP300 CBP, identifying chemical matter that selectively targets CBP proven challenging. Here,...
Carbon amendments designed to remediate environmental contamination lead substantial perturbations when injected into the subsurface. For remediation of uranium contamination, carbon promote reducing conditions allow microorganisms reduce an insoluble, less mobile state. However, reproducibility these and underlying microbial community assembly mechanisms have rarely been investigated in field. In this study, two injections emulsified vegetable oil were performed 2009 2017 immobilize...
Abstract Fear conditioning (FC) allows the dissociation of hippocampal and nonhippocampal behavioral function in rodents, has become a diagnostic tool transgenic mouse research employed to investigate mutation‐induced changes brain function. Although procedural details paradigm have been established, quantification output, freezing, remains problematic mice. Observation‐based techniques are time‐consuming may be subject bias, while movement detection with photocells is imprecise. Here we...
Abstract CREB binding protein (CBP) and E1A (EP300) are paralog histone acetyltransferases involved in many cellular processes via their activity as transcription factor co-activators. Dysregulation of one or both proteins has been implicated various cancer types, functional genomic screens have revealed a bidirectional synthetic lethal relationship between these two paralogs tumor cells. Due to the high homology CBP EP300, identifying selective chemical matter that selectively disrupts...
Abstract Background BMI has been implicated as a risk factor for heart disease whole in multiple studies. Heart attack is one of the common complications this disease. The aim study to explore if elevated level causes an increase attacks. Methods We used two Mendelian randomisation (MR) methods: inverse variance weighted estimation and robust adjusted profile score (RAPS) on basis summary data adulthood from Genetic Investigation Anthropometric Traits consortium UK Biobank. associated single...
Hearing aid verification with real-ear measurement (REM) is recommended in clinical practice. Improvements, over time, accuracy of manufacturers' initial fit mean the benefit routine REM for new adult users unclear. This registered, double-blinded, randomized, mixed-methods trial aimed to (i) determine whether hearing prefer or and (ii) investigate reasons preferences. New (n = 45) were each fitted two programs: fit, both adjustments based on immediate feedback from patient. Participants...
Chemotherapy-induced peripheral neuropathy (CIPN) is considered a primary mechanism of imbalance among women diagnosed with breast cancer. Recent evidence, however, suggests that cancer-related fatigue (CRF) may also influence balance.Examine the contributions CRF and CIPN to static dynamic balance before after period fatiguing exercise.This secondary analysis data examining functional differences between cancer without persistent CRF. Postural sway was measured during standing rising phase...
<h3>Background</h3> Movement-evoked pain and impaired joint mobility are common comorbidities in inflammatory diseases such as Rheumatoid Arthritis (RA) Osteoarthritis. The Janus kinase (JAK) pathway has been implicated both inflammation chronic pain. Clinical data suggests that baricitinib, a selective JAK 1/2 inhibitor, can robustly rapidly alleviate RA.<sup>1</sup>Utilizing rodent forced-ambulation model, we have previously shown attenuation of gait deficits with analgesics opioids,...
In the United Kingdom, coronavirus disease 2019 (COVID-19) pandemic has led to cessation of elective surgery. However, there remains a need provide urgent and emergency cardiac thoracic surgery as well continue time-critical cancer This study describes our early experience implementing protocol safely deliver major in midst pandemic.Data on all patients undergoing cardiothoracic at single tertiary referral center London were prospectively collated during first 7 weeks lockdown Kingdom. A...
Soldiers must be able to perform a multitude of physically demanding tasks as part their regular duty, but physical readiness is often degraded due pain and musculoskeletal injury (MSKI). The presence with movement has been associated increased MSKI risk in Soldiers. Improved awareness the prevalence painful movements uninjured could help inform Army mitigation efforts. purpose this study was identify population healthy active duty
Abstract CREB binding protein (CBP) and E1A P300 (EP300) are paralog histone acetyltransferases that can function as transcriptional coactivators to regulate diverse cellular processes. Mutations in CBP EP300 have been implicated the biology of various cancer types. Functional genomic screens revealed a bidirectional synthetic lethal relationship between these paralogs tumor cells, highlighting therapeutic opportunity targeting selectively EP300-mutant cancers while sparing other tissues...
Firefighters work in a dangerous profession with high injury rates. Mobility dysfunction firefighters may impact performance and contribute to injury. The Functional Movement Screen (FMS) is commonly used evaluate individuals for mobility compensatory movements. purpose of this study was identify if related firefighters' occupational task performance. This retrospective assessing 29 career using FMS scores. Statistical analyses consisted multiple linear regression predictors on performance,...