A5084339167- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Cancer Cells and Metastasis
- Visual and Cognitive Learning Processes
- Chromatin Remodeling and Cancer
- Educational Strategies and Epistemologies
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Retinal Diseases and Treatments
- Aging and Gerontology Research
- Cancer Genomics and Diagnostics
- Education and Critical Thinking Development
- Corneal Surgery and Treatments
- melanin and skin pigmentation
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Technology Use by Older Adults
- Migration, Aging, and Tourism Studies
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Hair Growth and Disorders
- Reading and Literacy Development
- Histone Deacetylase Inhibitors Research
Foghorn Therapeutics (United States)
2023-2024
Massachusetts Institute of Technology
2020-2023
Allen Institute
2021-2023
Koch Institute for Integrative Cancer Research At MIT
2021-2023
University of Wisconsin–Madison
2014-2018
Emory University
2008
Idaho State University
1979-1980
Degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is essential for vision, and studies have implicated altered POS processing in the pathogenesis some degenerative diseases. Consistent with this concept, a recently established hiPSC-RPE model inherited macular degeneration, Best disease (BD), displayed reduced rates breakdown. Herein we utilized to determine (i) if disturbances protein degradation pathways are associated delayed digestion (ii) whether such...
Purpose: RPE cell transplantation as a potential treatment for AMD has been extensively investigated; however, in AMD, ultrastructural damage affects both the and its underlying matrix support, Bruch's membrane (BrM). An monolayer supported by surrogate scaffold could thus provide more effective approach to cell-based therapy AMD. Toward this goal, we aimed establish functional human induced pluripotent stem cell–derived (hiPSC)-RPE on Bombyx mori silk fibroin (BMSF) scaffold. Methods:...
EMT induces cilium assembly and signaling to promote mammogenesis tumorigenesis.
This study examines the processing strategies of average and below readers in response to factual inferential questions. Thirty-six sixth seventh grade students were given three equivalent passages 1500 words read. With each passage, Ss four questions, placed as pre-questions, post-questions, or interspersed The Ss, tested individually, answered adjunct questions orally probed for explanations their answers. concludes that perform better than on inferential, but not two passages. Ability...
The epigenetic repressor BMI1 plays an integral role in promoting the self-renewal and proliferation of many adult stem cell populations, also tumor types, primarily through silencing Cdkn2a locus, which encodes suppressors p16
Readarama was established for a community retirement center in Athens, Georgia. The sessions, held 1 hour weekly 12 weeks, were attended by healthy and active elderly women whose ages ranged from 59 to 75. participants lifelong readers who enjoyed reading as hobby social outlet. representative of the entire adult population, not subgroup be labeled elderly. points out value group an outlet already‐established means forming contacts retiree.
Abstract CREB binding protein (CBP) and E1A P300 (EP300) are paralog histone acetyltransferases that can function as transcriptional coactivators to regulate diverse cellular processes. Mutations in CBP EP300 have been implicated the biology of various cancer types. Functional genomic screens revealed a bidirectional synthetic lethal relationship between these paralogs tumor cells, highlighting therapeutic opportunity targeting selectively EP300-mutant cancers while sparing other tissues...
Abstract The BRG/BRM-associated factor (BAF) complex plays critical roles in chromatin regulation. Within this complex, the two mutually exclusive ATPases BRM and BRG1 (SMARCA2 SMARCA4, respectively) drive remodeling activity. Genetic alterations SMARCA4 gene, encoding BRG1, are found approximately 10% of non-small cell lung cancer (NSCLC) patients, leaving subset BRG1-deficient tumors highly susceptible to inhibition. In addition, has oncogenic activity NSCLC, rationalizing use a dual...
ABSTRACT Thirty‐six sixth and seventh graders were given three equivalent passages to read, with questions placed as pre‐questions, post‐questions, interspersed post‐questions. The students, divided into two reading ability levels tested individually, answered the four factual inferential adjunct took a multiple choice test over each passage after reading. Multivariate analyses computed for passage. Average readers performed better than below average on of passages, but no differences noted...
Abstract The BRG/BRM associated factor (BAF) complex is a chromatin remodeler critical for maintenance of cell viability in many cancers. This includes acute myeloid leukemia (AML), where BAF maintains the stem-like transcriptional state blast cells. FHD-286 dual inhibitor ATPase subunits BRG1 and BRM currently being investigated relapsed or refractory AML myelodysplastic syndrome. We have shown previously that induces expression differentiation marker CD11b preclinical models after...
Abstract The epithelial-mesenchymal transition (EMT) is a key cell-biological program enabling carcinoma cell phenotypic plasticity. Accumulating evidence suggests EMT programs do not operate as stereotypical that functions binary switch, shifting cells from an epithelial (E) to mesenchymal (M) state. Instead, generate enter into series of intermediate states arrayed along the E-M spectrum. At present, we still lack coherent understanding how control their entrance and residence in these...
Abstract The Epithelial–Mesenchymal Transition (EMT) and primary ciliogenesis induce stem cell properties in basal Mammary Stem Cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that EMT transcription factors at intermediate transition states by activating inducers, including FGFR1. resulting cilia BBS11-dependent ubiquitination inactivation of a central signaling node, GLIS2. We GLIS2 promotes MaSC stemness, is required for...