A5029854876- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Musicians’ Health and Performance
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Gut microbiota and health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Urinary Tract Infections Management
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Caveolin-1 and cellular processes
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Cancer-related Molecular Pathways
- Neurogenetic and Muscular Disorders Research
- Ferroptosis and cancer prognosis
Whitehead Institute for Biomedical Research
2020-2024
Florida State University
2014-2021
We looked at a disease-associated macrosatellite array D4Z4 and focused on epigenetic factors influencing its chromatin state outside of the disease-context. used HCT116 cell line that contains non-canonical polyadenylation (poly-A) signal required to stabilize somatic transcripts human double homeobox gene DUX4, encoded from D4Z4. In HCT116, is packaged into constitutive heterochromatin, characterized by DNA methylation histone H3 tri-methylation lysine 9 (H3K9me3), resulting in low basal...
Abstract Facioscapulohumeral muscular dystrophy (FSHD) is a debilitating muscle disease that currently does not have an effective cure or therapy. The abnormal reactivation of DUX4 , embryonic gene epigenetically silenced in somatic tissues, causal to FSHD. Disease-specific has two common characteristics, the presence non-canonical polyadenylation sequence within exon 3 stabilizes pathogenic transcripts, and loss repressive chromatin modifications at D4Z4, macrosatellite repeat which encodes...
ABSTRACT Cancer cell fate has been widely ascribed to mutational changes within protein-coding genes associated with tumor suppressors and oncogenes. In contrast, the mechanisms through which biophysical properties of membrane lipids influence cancer survival, dedifferentiation metastasis have received little scrutiny. Here, we report that cells endowed a high metastatic ability stem cell-like traits employ ether maintain low tension fluidity. Using genetic approaches lipid reconstitution...
Urinary tract infections (UTIs) are the leading cause of hospitalization due to bacterial infection, and frequency multidrug-resistant Escherichia coli isolates from these is increasing worldwide. The current study aims isolate characterize antibiotic-resistant their antibiogram typing urine samples humans. From April December 2019, a total 60 human were collected aseptically treated primary isolation by propagation in nutrient broth followed culture on various agar media. Gram’s staining,...
Abstract While major advancements have been made in treatment of primary tumors estrogen receptor-positive (ER+) breast cancer, reducing mortality from metastatic cancer (mBC) treated patients who develop endocrine resistance to first line therapies remains an unmet clinical need. Wild-type ER activity or availability its cognate ligand 17-beta estradiol (E2) are factors tumor progression, which lost/reduced due treatments, such as use selective degraders (SERDs) and aromatase inhibitors...
Abstract The epithelial-mesenchymal transition (EMT) is a key cell-biological program enabling carcinoma cell phenotypic plasticity. Accumulating evidence suggests EMT programs do not operate as stereotypical that functions binary switch, shifting cells from an epithelial (E) to mesenchymal (M) state. Instead, generate enter into series of intermediate states arrayed along the E-M spectrum. At present, we still lack coherent understanding how control their entrance and residence in these...