A5016607253- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- Platelet Disorders and Treatments
- Complement system in diseases
- Neurological and metabolic disorders
- Hemoglobinopathies and Related Disorders
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Hematological disorders and diagnostics
- Pluripotent Stem Cells Research
- Cytomegalovirus and herpesvirus research
- Autoimmune and Inflammatory Disorders Research
- CAR-T cell therapy research
- Pituitary Gland Disorders and Treatments
- T-cell and B-cell Immunology
- Biological Research and Disease Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
Armed Forces Institute of Pathology
2021-2025
Ministry of Health and Family Welfare
2025
Unity Health System
2025
National University of Medical Sciences
2019-2024
Military Hospital
2024
GTx (United States)
2024
National Institute Of Blood Disease and Bone Marrow Transplantation
2017-2023
Lahore School of Economics
2023
All India Institute of Medical Sciences
2022
John Peter Smith Hospital
2019-2022
Significance Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. We used genome-wide CRISPR-Cas9 knockout screen to identify ZIKV host genes in neural progenitors. The identified factors involved heparan sulfation, endocytosis, endoplasmic reticulum processing, Golgi function, interferon activity. Our findings provide insights into host-dependent mechanisms for infection highly vulnerable progenitor cells...
Pakistan suffers from floods in the main rivers of Indus River System due to disturbed weather patterns during monsoon and snowmelt. The study aims identify community perspectives on socioeconomic impacts Central (Punjab Sindh), Pakistan. A questionnaire-based survey was conducted three major biodiversity hotspot areas: Taunsa Barrage Wildlife Sanctuary, Dolphin Reserve, Wetlands Complex. questionnaire identified people's knowledge, practice, attitude regarding area. results were interesting...
Objective: Prevalence of aplastic anemia (AA) is high in the Asian population. This study was done to explore etiology and association AA with various socio-economic environmental factors.Study design setting: Study included 1324 consecutive cases registered at Armed Forces Bone Marrow Transplant Centre Rawalpindi, Pakistan, from March 2001 August 2016. The questionnaire completed through an interview. It patients' socio-demographic details, personal family medical history, attributes...
Introduction Rare bleeding disorders (RBDs) result from genetic mutations in clotting factors. These RBDs vary prevalence and are often underdiagnosed due to mild symptoms. Treatment is challenging limited clinical data primarily involves substituting deficient factors using adjuvant therapies. Women with face unique risks, including gynecologic bleeding, hemorrhagic ovarian cysts, complications during pregnancy. issues can significantly impact their quality of life employment. This study...
To determine the mobilisation failure rate and identify its associated factors in this part of world order to patients at risk promptly explore alternative treatment. A descriptive study. Place Duration Study: Department Clinical Haematology, The Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan, from January 2014 July 2023. records 115 due for autologous haematopoietic stem cell transplantation (auto HSCT) undergoing regimen were analysed. Poor mobilisers defined as who...
The Government of Bangladesh established a visual inspection with acetic acid (VIA)-based cervical cancer screening programme at 600 primary, secondary and tertiary health facilities following pilot in 2005. An aggregated data collection system was initiated using District Health Information System 2 (DHIS2) software 2013 case-based electronic registry developed utilising its "tracker" component since January 2018. purpose this study is to review the surveillance situation based on national...
To determine the outcomes of autologous haematopoietic stem cell transplant (auto HSCT) in lymphoma patients terms overall survival (OS), disease-free (DFS), and treatment-related mortality to identify associated factors. A descriptive study. Place Duration Study: Department Clinical Haematology, The Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan, from February 2006 2023. records 59 who underwent auto HSCT were analysed. Median OS DFS was calculated by applying Kaplan-Meier...
Background: Management of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) are challenging in low-middle income countries (LMICs) due to lack advanced diagnostics for risk stratification, restricted finances trained manpower infrastructure handling patients with intensive chemotherapy. Venetoclax when combined hypomethylating agents (HMA) such as decitabine or azacitidine inhibit electron transport chain complex II resulting metabolic disruption eradication leukemia stem...
Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, impact CLL-related factors and CLL-directed treatment is still unclear represents focus this work. We conducted retrospective international multicenter study assess incidence OMs detect potential in 19,705 patients CLL, small lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 2016. Data collection took...
To describe attrition patterns of opioid use disorder (OUD) patients treated with buprenorphine (BUP) and to assess how clinical, sociodemographic, or BUP medication dosing features are associated attrition.Electronic health records adults (16+ year-olds) OUD from 23 different substance mental care programs across 11 US states were examined for one year following initiation in inpatient (IP), intensive outpatient (IOP), (OP) settings. Treatment was declared at >37 days the last recorded...
Human epididymis protein 4 (HE4) has received much attention recently due to its diagnostic and prognostic abilities for epithelial ovarian cancer. Since inclusion in the Risk of Ovarian Malignancy Algorithm (ROMA), studies have focused on functional effects Here, we aimed investigate role HE4 invasion, haptotaxis, adhesion cancer cells. Furthermore, sought gain an understanding relevant transcriptional profiles kinase signaling pathways mediated by this multifunctional protein. Exposure...
Despite excellent transplant outcomes of aplastic anemia (AA) in developed countries, management developing countries is challenging because delay the diagnosis, use family donors for transfusions, and higher infection risk pretransplant. These factors can lead to allo-immunization, increased graft failure, graft-versus-host disease (GVHD), transplant-related mortality, leading unfavorable outcomes. Conventional cyclophosphamide (Cy) antithymocyte globulin (ATG) are associated with inferior...
Glanzmann thrombasthenia (GT) is a rare disease with an autosomal recessive inheritance pattern. This disorder not so uncommonly encountered in routine clinical practice and laboratory settings Pakistan let alone the rest of world. To describe bleeding phenotype GT treatment outcomes over one hundred patients north Pakistan.
Background: Lorazepam use in the treatment of alcohol withdrawal syndrome (AWS) is not without risk.Objective: This study compares AWS outcomes using a standard, symptom-triggered lorazepam dosing protocol (control group) and augmented with gabapentin loading dose taper (GABA group).Methods: Consecutive, non-randomized adults (n = 982; 64.0% male) undergoing for were included this retrospective, open-label study. Symptom-triggered was informed by scores on Clinical Institute Withdrawal...