Sean Harrop
A5052664154- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- Viral-associated cancers and disorders
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Nail Diseases and Treatments
- Blood transfusion and management
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Forest Insect Ecology and Management
- Genomics and Rare Diseases
- CNS Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Blood groups and transfusion
Peter MacCallum Cancer Centre
2020-2025
The Royal Melbourne Hospital
2024-2025
The University of Melbourne
2023-2024
St Vincent's Hospital
2023-2024
Centre Hospitalier du Mans
2023
University of Ioannina
2023
Epworth Hospital
2020-2021
Summary Germline homozygous loss‐of‐function mutations in TET2 result significant childhood immunodeficiency that resembles autoimmune lymphoproliferative syndrome and predisposes one to lymphoma. The implications of heterozygous variants are less well understood. We describe four patients with germline who presented B‐cell lymphoma on a background chronic lymphadenopathy features. This expands the association an syndrome‐like phenotype state. Assessment for origin should be considered...
Summary Glofitamab is a CD3‐CD20 bispecific antibody used to treat B‐cell non‐Hodgkin lymphoma. We describe three cases of enterocolitis occurring with glofitamab at single institution. Similarities between include onset post cycle 4–5, moderately elevated faecal calprotectin, abnormal bowel avidity on positron emission tomography scan (2/3), absence CD20‐positive B cells gut histology and steroid responsiveness. There was variability in the area gastrointestinal inflammation, severity...
Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, impact CLL-related factors and CLL-directed treatment is still unclear represents focus this work. We conducted retrospective international multicenter study assess incidence OMs detect potential in 19,705 patients CLL, small lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 2016. Data collection took...
Abstract UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia have been reported to be associated with a poor prognosis. Co‐mutations WT1 FLT3 common while morphological dysplasia is frequent. The role of UBTF‐TDs leukemogenesis yet elucidated; however they proposed as early initiating events, making them attractive for assessment MRD potential therapeutic target. We present two cases where the UBTF‐ TD was observed remission discuss implications these...
The characterisation of the lymphoma epigenome has provided insight into mechanisms involved in lymphomagenesis. Multiple subtypes demonstrate recurrent mutations key epigenetic regulators that have been utilised to define clinicogenetic groups can predict clinical behaviour these heterogenous entities. high frequency provides rationale incorporate classification some lymphoma. In addition, their nature a target such mutations, or relevant pathway, for treatment. this review, we summarised...
Sean Harrop, Pietro Di Ciaccio, Nicole Wong Doo, Tara Cochrane, Belinda A. Campbell, Nada Hamad, Michael Dickinson, Carrie Van Der Weyden, Henry Miles Prince
Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell associated with breast prostheses. Most patients present localised periprosthetic effusion and are managed removal the implant surrounding capsule. Less commonly, can form mass capsule rarely disseminated disease. Recent series characterising genomic landscape BIA-ALCL have led to insights into mechanisms lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as likely key component while,...
Background: Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, impact CLL-related factors and CLL-directed treatment is still unclear. Aims: We aimed (i) determine incidence OMs in population patients CLL, (ii) assess overall survival (OS) CLL OM, (iii) find for occurrence OM CLL. Methods: This retrospective international multicenter study conducted by European Research Initiative on context...
We report a case of primary cutaneous anaplastic large cell lymphoma (C-ALCL) which demonstrates the locoregional nodal spread C-ALCL and subsequent progression to visceral disease respo...