A5063556091- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Advanced Radiotherapy Techniques
- HER2/EGFR in Cancer Research
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Patient Satisfaction in Healthcare
- CNS Lymphoma Diagnosis and Treatment
- Patient-Provider Communication in Healthcare
- Medical Imaging and Pathology Studies
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Technostress in Professional Settings
Hospital Prof. Dr. Fernando Fonseca
2019-2025
Hospital de Santo António
2024
Hospital Beatriz Ângelo
2022-2024
Hospital da Luz
2024
University of Lisbon
2023
IPO Porto
2023
Centro Hospitalar de Trás os Montes e Alto Douro
2023
Companhia União Fabril
2022
Hospital of St. Francis Xavier
2022
Centro Hospitalar de Vila Nova de Gaia
2019-2021
In this first analysis, samples from 23 BC survivors (group 1) and 291 healthy female controls 2) were characterised through the V3 V4 regions that encode “16S rRNA” gene of each bacteria. The sequenced by next-generation sequencing (NGS), taxonomy was identified resorting to Kraken2 improved with Bracken, using a curated database called ‘GutHealth_DB’. α β-diversity analyses used determine richness evenness gut microbiota. A non-parametric Mann-Whitney U test applied assess differential...
Substantial improvements in survival have been observed HER2 (human epidermal growth factor receptor 2)-positive (HER2+) inoperable or metastatic breast cancer (advanced [ABC]) recent years, driven by the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared efficacy safety trastuzumab deruxtecan (T-DXd) patients with HER2+ ABC formerly treated emtansine (T-DM1), demonstrating significant both overall (OS) progression-free (PFS). We conducted a...
Introduction The standard treatment of cancer has dramatically improved with immune checkpoint inhibitors (ICIs). Despite their proven advantage, many patients fail to exhibit a meaningful and lasting response. beta-adrenergic signalling pathway may hold significant promise due its role in promoting an immunosuppressive milieu within the tumour microenvironment. Inhibiting β-adrenergic could enhance ICI activity; however, blocking this for purpose yielded conflicting results. primary...
The first medical oncology appointment serves as a platform for patients to comprehend their diagnosis and prognostic implications of cancer. This study aimed determine patients' communication preferences during assess the disparities between perceptions.A total 169 cancer participated by completing Communication in First Medical Oncology Appointment Questionnaire (C-FAQ), two-section questionnaire designed perceptions regarding Content (information provided its extent), Facilitation (timing...
The purpose of this study is to describe and analyze whether digital remote work in times Covid-19 influencing the satisfaction Public Administration employees. Based on objective study, an online survey was conducted Portuguese Administration, for a sample 70 individuals, working at home due situation Health caused by Coronavirus. Digital being applied massively worldwide specific form organization supported information knowledge. workers carry out their activities using technologies,...
Substantial improvement in survival has been seen HER2+ advanced breast cancer (ABC) over the past years with introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared efficacy safety T-DXd versus physician's choice therapy unresectable and/or metastatic previously treated trastuzumab emtansine (T-DM1). It showed a significant overall (OS) progression-free (PFS). We conducted national, multicentric, retrospective study describing real-world treatment...
This study aimed to characterize the employment status and work-related conditions of patients with advanced breast cancer (ABC) in Portugal quantify productivity costs premature abandonment work market while evaluating strategies promote employment. The analysis was based on a cumulative incidence model for estimation ABC prevalence cross-sectional characterizing ABC. conducted Portuguese hospitals, between Nov2021-Dec2022 included diagnosed at least 6 months, aged 66 or less consenting...
Peritoneal metastasis is the most common pattern of synchronous and metachronous dissemination in gastric cancer (GC) associated with a poor prognosis. Even though systemic chemotherapy standard care, optimal therapeutic approach to peritoneal disease this setting yet be defined. We present case 26-year-old female diagnosed locally advanced GC who developed carcinomatosis (PC). The patient underwent cytoreductive surgery (CRS) along hyperthermic intraperitoneal (HIPEC) complete remission....
Background The treatment standard of cancer has dramatically diverted with immune checkpoint inhibitors (ICI). Despite the proven advantage, many patients fail to achieve a meaningful and durable response. Recent data shown that targeting β-adrenergic receptor signaling improves clinical outcomes in cancer. This pathway also been promote an immunosuppressive tumor microenvironment (TME). Inhibiting could enhance ICI activity; however, blocking this for purpose yielded conflicting...
The treatment paradigm of neoplastic diseases has dramatically shifted with the introduction immune checkpoint inhibitors (ICI). They induce a durable response in wide variety solid tumors, but this depends on infiltration lymphocytes capable recognizing and killing tumor cells. primary predictor intrinsic resistance to ICIs is absence tumor, so-called “cold tumors”. Colorectal cancer (CRC) remains one most common challenging cancer, it not traditionally considered highly immunogenic tumor....
The tumor microenvironment is crucial in tumourigenesis, response to therapy, and elimination of cells. Tumor-infiltrating lymphocytes (TILs) promote the host immune are associated with a better prognosis colorectal cancer (CRC). This multicentric retrospective study evaluated relationship between presence intensity TILs survival outcomes. A total 651 patients from four Portuguese oncological centers who underwent surgical resection for stages II or III adenocarcinoma 2016 2019 were included...
Breast cancer (BC) is the most commonly diagnosed and second cause of cancer-specific death in women worldwide. Increasing evidence suggests that gut microbial dysbiosis may have a role to play pathogenesis, treatment prognosis BC. The "BiotaCancerSurvivors" was prospective, longitudinal, observational, unicentric case-control study aimed analyse whether microbiota differs between survivors database healthy controls. In this first analysis, samples from 23 BC (group 1) 291 female controls 2)...
Introduction: Gray zone lymphomas have overlapping features between primary mediastinal B-cell lymphoma (PMBCL) and classic Hodgkin (cHL). It is a rare aggressive entity without standard treatment. For relapsed/refractory cases, salvage regimens followed by autologous transplant are recommended. However, many cases resistant to immunochemotherapy. cHL PMBCL high response rates check point inhibitors (CPI) that could therefore be useful in GZL. We report our single center experience with CPI...