A5101957980- Myofascial pain diagnosis and treatment
- Alkaline Phosphatase Research Studies
- Musculoskeletal pain and rehabilitation
- Bone and Joint Diseases
- Heterotopic Ossification and Related Conditions
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Liver Diseases and Immunity
- Musculoskeletal synovial abnormalities and treatments
- Gastric Cancer Management and Outcomes
- Orthopaedic implants and arthroplasty
- Pediatric Hepatobiliary Diseases and Treatments
- Pain Management and Treatment
- Hemoglobinopathies and Related Disorders
- Infrared Thermography in Medicine
- Connective tissue disorders research
- Biomedical and Chemical Research
- Exercise and Physiological Responses
- Hematological disorders and diagnostics
- Osteoarthritis Treatment and Mechanisms
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Vitamin D Research Studies
Steno Diabetes Centers
2024
Copenhagen University Hospital
2024
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2022-2024
Universität Hamburg
2012-2022
University Medical Center Hamburg-Eppendorf
2016-2022
Krankenhaus Reinbek - Startseite
2019
HNO Bad Bramstedt
2018
Heidelberg University
2014-2017
University Hospital Heidelberg
2014-2017
Martini-Klinik
2017
The aim of this retrospective study was to investigate the frequency intra-articular osteoid osteoma (iaOO) in a large cohort and demonstrate its clinical relevance as an important differential diagnosis non-specific mono-articular joint pain.We searched registry for bone tumours University Medical Centre Hamburg-Eppendorf osteomas last 42 years. Herein, we present three selected iaOO which were detected major weight-bearing joints. Computed tomography (CT) or magnetic resonance imaging...
Impaired bone quality is associated with poor outcome of spinal surgery. The aim the study was to assess mineral status patients scheduled undergo surgery and report frequencies disorders.We retrospectively analyzed 144 requiring including density by dual-energy X-ray absorptiometry (DXA) as well laboratory data serum levels 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, specific alkaline phosphate, osteocalcin, gastrin. High-resolution peripheral quantitative computed...
Tissue-nonspecific alkaline phosphatase (TNSALP) encoded by the ALPL gene is of particular importance for bone mineralization. Mutation in can lead to persistent low ALP activity resulting rare disease Hypophosphatasia (HPP) that characterized disturbed and dental While severe forms are extremely with an estimated prevalence 1/100.000, recent studies suggest moderate form caused heterozygous mutations much more frequent 1/508. The purpose this study was estimate AP levels population based on...
Abstract Hereditary hemochromatosis (HHC) is characterized by excessive intestinal iron absorption resulting in a pathological increase of levels. Parenchyma damage may be consequence deposition affected organs (e.g., liver, pancreas, gonads) as well bones and joints, leading to osteoporosis with increased fracture risk arthropathy. Up date, it not known whether HHC can also considered factor for osteonecrosis. Likewise, the underlying skeletal changes are unknown regarding, e.g.,...
ABSTRACT Primary biliary cholangitis (PBC) is known to be a major risk factor for osteoporosis reflected by reduction of bone mineral density (BMD). However, both the extent macro- and microstructural alterations as well causative factors are unknown. We have retrospectively analyzed total 96 patients with PBC 53 healthy controls matched age, sex, body mass index. In addition dual-energy X-ray absorptiometry (DXA) measurements at lumbar spine hip, high-resolution peripheral quantitative...
Abstract Hypophosphatasia (HPP) is a rare inborn error of metabolism due to decreased activity tissue nonspecific alkaline phosphatase (TNSALP). As the onset and severity HPP are heterogenous, it can be challenging determine pathogenicity detected ALPL variants in symptomatic patients. We aimed characterize patients with propose which diagnosed adult HPP. included 72 (1) clinical symptoms or positive family history (2) low TNSALP and/or high pyridoxal 5′-phosphate (PLP) levels, who underwent...
The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort patients with BMES was performed to characterise the overall skeletal status turnover BMES, aim identifying risk factors for this disease.Patients who were diagnosed on basis clinical radiological (magnetic resonance imaging) findings our outpatient clinic identified retrospectively. Patient history, co-existing metabolic disorders,...
Background: The thoracolumbar fascia (TLF) is thought to play a role in the development of LBP, but it not yet clear which factor TLF changes cause and an effect. Therefore, some studies used cross-correlation function (CCR) reveal time-dependent relationships between biomechanical neuromotor factors. Methods: Ten patients with acute low back pain (aLBP) were matched healthy controls. Simultaneous recording surface electromyography (sEMG) erector spinae muscle (ES) dynamic ultrasound (US)...
To assess the effectiveness of osteopathic intervention (OI) and general treatment (GOT) in individuals with fibromyalgia syndrome (FMS).The trial was designed as a randomized controlled 2 interventions 1 untreated control group. The patients two groups received 10 treatments (OI or GOT) within time period 12 weeks. group did not receive any treatment. primary outcome average pain intensity (API) assessed by visual analog scale (VAS). Secondary outcomes were pressure-pain threshold rated...
The acetabular labrum of the hip (ALH) is recognized as a clinically important structure, but knowledge about pathophysiology this fibrocartilage scarce. In prospective study we determined prevalence ALH calcification in patients with end-stage osteoarthritis (OA) and analyzed relationship cartilage (CC) pain clinical function. Cohort 80 (70.2 ± 7.6years) primary OA scheduled for total replacement. Harris Hip Score (HHS) was recorded preoperatively. Total femoral head (FH) were sampled...
The purpose of this study was to investigate the relationship between clinical disease activity in patients with advanced stage rheumatoid arthritis (RA) on treatment Disease Modifying Antirheumatic Drugs (DMARDs) and histopathological scores synovial inflammation. To end, biopsies 62 RA who underwent surgery for either synovectomy or total joint arthroplasty were assessed by a general synovitis score (GSS) an immunologic (IMSYC). index (CDAI) significantly correlated both GSS IMSYC (r =...
The response to teriparatide has been described in very few cases of hypophosphatasia (HPP). In this cross-sectional study, we report the prevalence symptomatic bone marrow edema (BME) and fracture healing complications a large cohort childhood adult HPP patients discuss results treatment four cases. From 2016 2018, 51 with diagnosis were seen at our institution. was established by low serum alkaline phosphatase (ALP), elevated pyridoxal-5-phosphate (PLP), least one typical clinical symptom...
Recently, it has been shown that the extramuscular connective tissue (ECT) is likely involved in delayed onset muscle soreness (DOMS). Therefore, aim of present study was to investigate effects maximal trunk extension eccentric exercise (EE) on ECT thickness, self-reported DOMS, stiffness, skin temperature, and possible correlations between these outcomes. Healthy adults (n = 16, 29.34 ± 9.87 years) performed fatiguing EE trunk. A group highly active individuals (TR, n 8, > 14 h sport per...
Objective: To examine the reliability and discriminative validity (patients vs. healthy individuals) of an ultrasound (US) measurement method for quantification thoracolumbar fascia deformation (TLFD). Design: Cross-sectional study with US assesment rater blinding.Setting: Manual therapy clinic, university laboratory.Participants: aLBP patients (n = 16) individuals 15).Interventions: Participants performed a standardized trunk extension task. measurements TLFD were carried out independendly...
<title>Abstract</title> Reduced shear strain and deformability of the thoracolumbar fascia has been linked to low back pain. A number ultrasound examination methods have developed for laboratory rather than clinical practice. The aim this study was examine reliability discriminative validity (patients vs. healthy individuals) an (US) measurement method quantification deformation (TLFD). Cross-sectional with US assessment rater blinding conducted in a manual therapy clinic university...