A5083197467- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Hippo pathway signaling and YAP/TAZ
- Proteoglycans and glycosaminoglycans research
- Cardiac and Coronary Surgery Techniques
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Signaling Pathways in Disease
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Biochemical Analysis and Sensing Techniques
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- Nanoparticle-Based Drug Delivery
- Cardiovascular Effects of Exercise
McGill University Health Centre
2013-2021
McGill University
2012-2017
Montreal Children's Hospital
2012
The use of stem cells in cardiac regeneration is still limited due to low cellular integration and engraftment rates. Consequently, there has been a spurt research on developing alternative regenerative therapies. Hyaluronic acid (HA) major component the extracellular matrix that non-immunogenic, implicated various wound-healing functions such as angiogenesis inflammation modulation, making it an ideal candidate for biomaterials. In this study, we examine potential acellular hyaluronic...
For more than a decade, stem cells isolated from different tissues have been evaluated in cell therapy. Among them, the human bone marrow-derived mesenchymal (hBM-MSCs) were investigated extensively treatment of myocardial infarction. Recently, placenta-derived (hPD-MSCs), which are readily available biological waste, appear to be viable alternative hBM-MSCs.C-X-C chemokine receptor type 4 (CXCR4) gene expression and localization detected validated hPD-MSCs hBM-MSCs via polymerase chain...
Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors live cells. We report a method produce tough, in-situ thermogelling, non-toxic, injectable made of chitosan hyaluronic acid co-crosslinked with β-glycerophophate genipin. The gels highly homogeneous form within 32 min, i.e., faster than crosslinked either genipin or β-glycerophophate. shear strength is 3.5 kPa, higher any chitosan-based gel reported. Chondrocytes...
The Hippo-signaling pathway is a mechanism implicated in cardiomyocyte cytoprotection and regeneration after myocardial infarction. Yes-associated protein 1, the main effector of this pathway, acts as co-transcriptional activator to promote proliferation survival. However, biological mechanisms by which yes-associated 1 protects heart post-MI are currently unknown. Here, we propose that plays critical role simulated ischemia-reperfusion injury. AC16 human cardiomyocytes were infected with...
Acute myocardial infarction (MI) remains one of the leading causes death worldwide with no curative therapy available. Stem cell therapies have been gaining interest as a means to repair cardiac tissue after MI and prevent onset heart failure. Many in vivo reports suggest that use stem cells is promising, yet clinical trials fail integrate into native tissue, resulting limited improvements function repair. To battle this limitation, combination using embedded bioactive scaffold promotes...
This study aims at modifying the synthesis method of preparing N-isopropylacrylamide (NIPAAM)/N-vinyl-2-pyrrolidone (VP)/Polyethylene glycol monoacrylate (PEG-A) polymeric nanoparticles encapsulating curcumin as a model drug. The optimal concentration nanoparticle reagents was determined using Fourier Transform Infrared Spectroscopy. Curcumin mean hydrodynamic size found to be 104 nm with zeta potential 3 ± 13 mV. release kinetic indicates that maximum 24 h positively correlates increase in...
The use of stem cells to repair the heart after a myocardial infarction (MI) remains promising, yet clinical trials over past 20 years suggest that fail integrate into native tissue, resulting in limited improvements cardiac function. Here, we demonstrate cardioprotective potential composite inserting human amniotic stromal mesenchymal (ASMCs) chitosan and hyaluronic acid (C/HA) based hydrogel rat MI model. Mechanical characterization C/HA platform indicated swift elastic conversion at 40°C...
Purpose: Human bone marrow mesenchymal stem cells (hbmMSCs) have been studied extensively for myocardial regenerative therapy. However, such require invasive procreation and suffer from donor age-related declining quality. Recently, a more abundant resource of young MSCs has isolated an otherwise discarded organ: the human placenta (hpMSCs). In this study, we wanted to examine survival, differentiation, functionality xenogeneic hpMSCs when implanted into induced rat infarction. Methods: To...