A5023222555- High Temperature Alloys and Creep
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Metallurgical Processes and Thermodynamics
- Fatigue and fracture mechanics
- Quinazolinone synthesis and applications
- Microstructure and Mechanical Properties of Steels
- Additive Manufacturing Materials and Processes
- Protein Kinase Regulation and GTPase Signaling
- Metallurgy and Material Forming
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Synthesis and Reactions
- Advanced Materials Characterization Techniques
- Mechanical Failure Analysis and Simulation
- Metal Alloys Wear and Properties
- Advanced Power Generation Technologies
- Biotin and Related Studies
- Cardiac Valve Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
Electric Power Research Institute
2022-2024
Pfizer (United States)
2002-2023
University of Oxford
1974
Abstract Signaling through the erbB receptor family of tyrosine kinases contributes to proliferation, differentiation, migration, and survival a variety cell types. Abnormalities in members this have been shown play role oncogenesis, thus making them attractive targets for anticancer treatments. PF-00299804 is second-generation irreversible pan-erbB kinase inhibitor currently phase I clinical trials. believed irreversibly inhibit activity binding at ATP site covalent modification...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfur as a regiochemical control element. Cycloadditions of 2-alkoxy(acyloxy)-3-alkyl(aryl)thiobuta-1,3-dienesBarry M. Trost, William C. Vladuchick, and Alex J. BridgesCite this: Am. Chem. Soc. 1980, 102, 10, 3554–3572Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 1980https://doi.org/10.1021/ja00530a041RIGHTS & PERMISSIONSArticle Views717Altmetric-Citations64LEARN ABOUT THESE METRICSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthetic reagents. 2-Methoxy-3-phenylthiobuta-1,3-diene. A novel annelating agentBarry M. Trost and Alex J. BridgesCite this: Am. Chem. Soc. 1976, 98, 16, 5017–5019Publication Date (Print):August 1, 1976Publication History Published online1 May 2002Published inissue 1 August 1976https://pubs.acs.org/doi/10.1021/ja00432a055https://doi.org/10.1021/ja00432a055research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfur as a regiochemical control element. Synthesis of 2-alkoxy(acyloxy)-3-alkyl(aryl)thiobuta-1,3-dienesBarry M. Trost, William C. Vladuchick, and Alex J. BridgesCite this: Am. Chem. Soc. 1980, 102, 10, 3548–3554Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 1980https://pubs.acs.org/doi/10.1021/ja00530a040https://doi.org/10.1021/ja00530a040research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylative eliminations. Scope of the activating groupBarry M. Trost and Alex J. BridgesCite this: Org. Chem. 1975, 40, 13, 2014–2016Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/jo00901a040https://doi.org/10.1021/jo00901a040research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations45LEARN ABOUT THESE METRICSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activity of 5-amino- 5-hydroxyquinolones, the overwhelming influence remote N1-substituent in determining structure-activity relationshipJohn M. Domagala, Alex J. Bridges, Townley P. Culbertson, Laura Gambino, Susan E. Hagen, Gregory Karrick, Kenneth Porter, Joseph Sanchez, Josephine A. Sesnie, Cite this: Med. Chem. 1991, 34, 3, 1142–1154Publication Date (Print):March 1, 1991Publication History Published online1 May...
As a test of the labelling characteristics photogenerated reagents, an aryl azide was photolysed in aromatic-binding locus protein known tertiary structure. The acyl-enzyme derived from reaction alpha-chymotrypsin with p-nitrophenyl ester p-azido[(14)C]cinnamate isolated and photolysed. About 60% acyl group is covalently bound to after photolysis deacylation, labelled enzyme inactive. attached label localized C chain chymotrypsin, there are firm indications that major tryptic fragment which...
Condition assessment of welded steam components is a crucial activity for safe power plant operations. In this work, remaining lifetime 141,000-hour service-aged large bore girth weld between an SA-182 forged 91 (F91) reducer and SA-335 pipe (P91) header was assessed with specially designed in-situ high temperature digital image correlation (DIC) system. Nonuniform creep deformation/damages in multi-pass F91-P91 welds were quantified characterized. The DIC strain measurements reveal the...
Abstract In this work, two unique heats of 9Cr creep strength enhanced ferritic (CSEF) steels extracted from a retired superheat outlet header after 141,000 hours service were evaluated. These CSEF forging manufactured to SA-182 F91 (F91) reducer and seamless pipe produced SA-335 P91 (P91) pipe. Their deformation fracture behavior assessed using lever arm frame integrated with in-situ high-temperature digital image correlation (DIC) system. Critical metallurgical microstructure factors,...
Abstract Ni-base superalloys used for hot section hardware of gas turbine systems experience thermomechanical fatigue (TMF), creep, and environmental degradation. The blades vanes industrial turbines (IGTs) are made from that either directionally-solidified (DS) or cast as single crystals (SX). Consequently, designing evaluating these alloys is complex since life depends on the crystallographic orientation in addition to complexities related cycling extent hold times at elevated temperature....
Abstract This study investigates the influences of product chemistry and grain size on high-temperature creep properties 316 stainless steels by analyzing an extensive range historical modern literature data. The investigated steel property dataset, including more than 160 heats 2,400 testing data, covers a wide spectrum elemental compositions forms. To perform prudent analysis statistical overview was first implemented to understand data distribution relevant sources, chemistries, forms,...
Abstract Steam methane reforming (SMR) is the most widely used process for bulk hydrogen production and accounts of produced worldwide. As this an highly endothermic reaction, large amount heat must be supplied to system, thus requiring resistant materials capable withstanding continued operation at temperatures exceeding 1,500°F (815°C). In study, microstructural characterization mechanical testing was conducted on in-service exposed HP40-modified material. Creep damage changes in...
Abstract A utility experienced cracking in multiple stage 2 buckets (S2Bs) a large F-class power generation gas turbine after only 7,348 hours and 31 starts following standard repair rejuvenation heat treatment cycle. The blades were cast from directionally solidified (DS) superalloy the was found shroud section Z-notch region. detailed failure investigation conducted to determine mechanism most likely contributing factors root cause terms of design, operation, fabrication, metallurgy. Three...
Supplementary Fig. S2 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
Supplementary Fig. S1 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
<div>Abstract<p>Signaling through the erbB receptor family of tyrosine kinases contributes to proliferation, differentiation, migration, and survival a variety cell types. Abnormalities in members this have been shown play role oncogenesis, thus making them attractive targets for anticancer treatments. PF-00299804 is second-generation irreversible pan-erbB kinase inhibitor currently phase I clinical trials. believed irreversibly inhibit activity binding at ATP site covalent...
<div>Abstract<p>Signaling through the erbB receptor family of tyrosine kinases contributes to proliferation, differentiation, migration, and survival a variety cell types. Abnormalities in members this have been shown play role oncogenesis, thus making them attractive targets for anticancer treatments. PF-00299804 is second-generation irreversible pan-erbB kinase inhibitor currently phase I clinical trials. believed irreversibly inhibit activity binding at ATP site covalent...
Supplementary Fig. S3 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
Supplementary Fig. S4 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
Supplementary Fig. S1 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor