A5033239699- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Visual perception and processing mechanisms
- AI in cancer detection
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Venomous Animal Envenomation and Studies
- Obesity and Health Practices
- Skin Protection and Aging
- Skin Diseases and Diabetes
- Cancer Risks and Factors
- Cutaneous lymphoproliferative disorders research
- Childhood Cancer Survivors' Quality of Life
- Neural dynamics and brain function
- Cancer Immunotherapy and Biomarkers
- Nail Diseases and Treatments
- Ion channel regulation and function
- Cancer and Skin Lesions
- Drug-Induced Adverse Reactions
- Drug-Induced Ocular Toxicity
- Genetic and rare skin diseases.
- Advanced Breast Cancer Therapies
- Acute Lymphoblastic Leukemia research
- Contact Dermatitis and Allergies
University of Kansas Medical Center
2024-2025
University of Kansas
2024-2025
Duke University Hospital
2024
Duke Cancer Institute
2023
Duke Medical Center
2023
Duke University
2023
University of Missouri
1983-2017
Longenecker and Associates (United States)
2014-2015
University of Missouri Hospital
2015
Washington University in St. Louis
1983-2014
The responses of visual cortical neurons during iontophoresis norepinephrine (NE) were compared in kittens and adult cats. One type neuronal "plasticity" (the ability to have their response properties markedly altered exposure a restricted environment) normally occurs only young has been hypothesized depend on the presence NE. We investigated this hypothesis terms model synaptic plasticity which suggested that NE would selectively enhance evoked enhancement might exist greater extent than...
We tested the theory that depletion of noradrenaline reduces plasticity visual cortex in kittens by using another method depletion. Lesions were made lateral hypothalamus to interrupt fibers dorsal noradrenergic bundle going from locus ceruleus telencephalon. The lesions induced at approximately 3 1/2 weeks age kittens; 2 later one eye was sutured shut, and about 10 days after cells recorded cortex. location verified histologically, effect analyses (high pressure liquid...
Computer-aided diagnosis of skin cancer requires accurate lesion segmentation, which must overcome noise such as hair, color variations, and ambient light variability.A biologically inspired geodesic active contour (GAC) technique is used for segmentation. The algorithm presented here employs automatic initialization close to the actual boundary, overcoming 'sticking' at minimum local energy spots caused by artifacts hair. border significantly smoothed mimic natural lesions. In addition,...
Cytomegalovirus colitis most commonly affects immunocompromised patients, although it is a rare cause of gastrointestinal bleeding in immunocompetent patients. Older age, chronic disease, and critical illness are also important risk factors may lead providers to consider the diagnosis otherwise Endoscopic presentation variable does not significantly influence outcomes. Although immunocompetent, noncritically ill patients improve with or without antiviral treatment, mortality rates as high...
Abstract Childhood cancer survivors, particularly those who received chest radiotherapy, are at high risk for developing subsequent breast cancer. Minimizing long-term toxicity risks associated with additional radiotherapy and chemotherapy is a priority, but therapeutic tradeoffs have not been comprehensively characterized their impact on survival unknown. In this study, 431 female childhood survivors from multicenter retrospective cohort study were evaluated. Compared one-to-one matched...
We tested the effects of 6-hydroxydopamine (6-OHDA) on two forms visual deprivation--monocular and directional deprivation. In normal kittens monocular deprivation leads to a change in ocular dominance histogram recorded from cortex, percentage directionally sensitive cells responding appropriate direction movement. 6-OHDA was infused into occipital cortex prior peak critical period for agreement with results Kasamatsu et al. (Kasamatsu, T., J. D. Pettigrew (1979) Comp. Neurol. 185: 139–162;...
Kittens were given N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to deplete cortical noradrenaline (NA) in order test whether this would affect the results of monocular deprivation. Seven kittens that received DSP-4 systemically had NA depleted by 25 98%, and six lateral ventricle 72 92%. In all these kittens, suturing shut eyelids one eye for 1 2 weeks produced a visual cortex which most neurons responded only or strongly remained open. These are considered together with previous...
Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in USA. In this research, we examine four different feature categories used for diagnostic decisions, including patient personal profile (patient age, gender, etc.), general exam (lesion size and location), common dermoscopic (blue-gray ovoids, leaf-structure dirt trails, specific lesion (white/pink areas, semitranslucency, etc.). Specific features are more restricted versions of features.Combinations analyzed over a data set...
TPS629 Background: Neoadjuvant chemoimmunotherapy is recommended for patients with high risk early stage TNBC. The 5 drug KEYNOTE-522 neoadjuvant regimen involves 5-6 months of treatment and associated suboptimal completion due to toxicity. Approaches deescalate without compromising outcomes highly chemosensitive disease are needed. Stromal tumor infiltrating lymphocyte (sTIL) enrichment positively pathologic complete response (pCR) in TNBC may be useful identify whom de-escalation might...
To describe children's consumption of sugar-sweetened beverages (SSBs) and 100% fruit juice (FJ), identify factors that may reduce excessive consumption.A total 830 parents young children completed a 36-item questionnaire at the pediatricians' office.Children consumed soda (62.2%), other SSBs (61.6%), FJ (88.2%): 26.9% exceeded American Academy Pediatrics' recommended daily intake. 157 (18.9%) calories (>200 kcal/d) from (median = 292.2 kcal/d, range 203.8-2177.0 kcal/d). Risk for calorie...
Background . In dermoscopic images, multiple shades of pink have been described in melanoma without specifying location these areas within the lesion. Objective The purpose this study was to determine statistics for presence centrally and peripherally located benign melanocytic lesions. Methods Three observers, untrained dermoscopy, each retrospectively analyzed 1290 images (296 melanomas (170 situ 126 invasive), 994 nevi) assessed any shade center periphery Results Pink peripheral region...
Photosensitivity to sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is reported. No previous reports of photosensitivity any DPP-4 inhibitors are known. Physical examination the patient revealed edematous plaques confined sun-exposed areas skin. An unusual finding in this case was spongy sensation upon palpation plaques. Histopathology parakeratosis and abundant eosinophils, supporting clinical impression cutaneous drug sensitivity. The eruption finally cleared, approximately two...
Bites from the brown recluse spider (BRS) can cause extreme pain. We propose cytokine release as a of discomfort and central mechanism through glial cell upregulation to explain measured pain levels time course.Twenty-three BRS bites were scored at probable or documented level clinically, an enzyme-linked immunosorbent assay was used confirm presence venom. The mean (SD) in these cases 24 hours after bite severe: 6.74 (2.75) on scale 0 10. Narcotics may be needed provide relief some cases....
Background Pink blush is a common feature in basal cell carcinoma ( BCC ). A related feature, semitranslucency, appears as smooth pink or orange regions resembling skin color. We introduce an automatic method for detection of these features based on smoothness and brightness. also neighborhood correction texture area correction. Methods Smoothness brightness were analyzed over four bands: luminance, red, green, blue, then merged using variance‐based dynamic thresholding. Dermoscopic images...