A5000019579- Muscle Physiology and Disorders
- Advanced biosensing and bioanalysis techniques
- bioluminescence and chemiluminescence research
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Effects of Exercise
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Hernia repair and management
- Surgical site infection prevention
- Intestinal and Peritoneal Adhesions
- Mitochondrial Function and Pathology
- Pineapple and bromelain studies
- Ion channel regulation and function
- Nanoparticle-Based Drug Delivery
- Reconstructive Facial Surgery Techniques
- Nasal Surgery and Airway Studies
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Quantum Dots Synthesis And Properties
- Surgical Sutures and Adhesives
- RNA Interference and Gene Delivery
Baylor College of Medicine
2021
Houston Methodist
2014-2021
Texas A&M University
2018
Tumor extracellular matrix (ECM) represents a major obstacle to the diffusion of therapeutics and drug delivery systems in cancer parenchyma. This biological barrier limits efficacy promising therapeutic approaches including siRNA or agents intended for thermoablation. After extravasation due enhanced penetration retention effect tumor vasculature, typical nanotherapeutics are unable reach nonvascularized anoxic regions deep within Here, we developed simple method provide mesoporous silica...
This report describes a novel, one-pot synthesis of hybrid nanoparticles formed by nanostructured inorganic silica core and an organic pH-responsive hydrogel shell. easy-to-perform, oil-in-water emulsion process synthesizes fluorescently-doped wrapped within tunable coating cationic poly(2-diethylaminoethyl methacrylate) in one step. Transmission electron microscopy dynamic light scattering analysis demonstrated that the hydrogel-coated are uniformly dispersed aqueous phase. The formation...
Mice lacking the sarcolemmal protein dystrophin, designated mdx, have been widely used as a model of Duchenne muscular dystrophy. Dystrophic mdx mice they mature develop notable morphological abnormalities to their neuromuscular junctions, peripheral cholinergic synapses responsible for activating muscle fibers. Most obviously acetylcholine receptor aggregates are fragmented into small non-continuous, islands. This contrasts with wild type whose continuous and pretzel-shaped in appearance....
The arrangement of myonuclei in skeletal muscle tissue has long been used as a biomarker for health, but there is dearth vivo exploration potential effects myonuclear organization on the function and regeneration because traditional nuclear stains are performed postmortem tissue. Therefore, we sought transgenic method to produce selective persistent label whole muscles living mice. We bred together mouse line with fiber-selective expression Cre recombinase second Cre-inducible fluorescently...
Background: Infected hernia mesh is a cause of post-operative morbidity. Nitric oxide (NO) plays key role in the endogenous immune response to infection. We sought study efficacy NO-releasing against methicillin-resistant Staphylococcus aureus (MRSA). hypothesized that polyester would decrease MRSA colonization and proliferation. Materials Methods: A composite functionalized with N-diazeniumdiolate silica nanoparticles was synthesized characterized. parietex (NOSi) inoculated 104,106, or 108...