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Jordan E. Brasuell

ORCID: 0000-0003-0343-1693
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About
Contact & Profiles
A5004932376
Research Areas
  • Nanoparticle-Based Drug Delivery
  • Angiogenesis and VEGF in Cancer
  • RNA Interference and Gene Delivery
  • Electrospun Nanofibers in Biomedical Applications
  • Advanced biosensing and bioanalysis techniques

Vanderbilt University
 2023

 Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
OPENALEX - Publications 
Shrusti S. Patel Ella N. Hoogenboezem Fang Yu Carlisle R. DeJulius R. Brock Fletcher and 9 more Alexander G. Sorets Fiona K. Cherry Justin H. Lo Mariah G. Bezold Nora Francini Richard d’Arcy Jordan E. Brasuell Rebecca S. Cook Craig L. Duvall

10.1016/j.biomaterials.2023.122098 article EN publisher-specific-oa Biomaterials 2023-03-28
 Abstract 11635: Device and Formulation Optimization for MK2 Inhibition and Restenosis Prevention at Sites of Peripheral Angioplasty
OPENALEX - Publications 
William S. Tierney Fang Yu Jackey Ma Joyce Cheung‐Flynn Megan Keech and 4 more Jordan E. Brasuell Devin Chang Colleen M. Brophy Craig L. Duvall

Introduction: Peripheral angioplasty often fails due to intimal hyperplasia (IH), where contractile smooth muscle cells (SMCs) de-differentiate into proliferative, migratory, and pro-inflammatory synthetic SMCs, leading restenosis. We have formerly shown that potentiation of an MK2 inhibitory peptide (MK2i) via delivery with poly(propyl acrylic acid) (PPAA) can block SMC phenotype switching neointima formation in a transplant model. This work develops strategies for targeted vivo MK2i+PPAA...

10.1161/circ.148.suppl_1.11635 article EN Circulation 2023-11-07
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