A5101936439- Cleft Lip and Palate Research
- Tracheal and airway disorders
- Neuroscience and Neuropharmacology Research
- Voice and Speech Disorders
- Craniofacial Disorders and Treatments
- Barrier Structure and Function Studies
- Head and Neck Surgical Oncology
- Neurological disorders and treatments
- Dysphagia Assessment and Management
- Botulinum Toxin and Related Neurological Disorders
- Vascular Anomalies and Treatments
- Head and Neck Cancer Studies
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
Cleveland Clinic
2011-2024
Cleveland Clinic Lerner College of Medicine
2017-2024
Case Western Reserve University
2024
Vanderbilt University
2023
Centre Hospitalier Universitaire Sainte-Justine
2017
Université de Montréal
2017
Health First
2017
A wind of change characterizes epilepsy research efforts. The traditional approach, based on a neurocentric view seizure generation, promoted understanding the neuronal mechanisms seizures; this resulted in development potent anti-epileptic drugs (AEDs). fact that significant number individuals with still fail to respond available AEDs restates need for an alternative approach. Blood-brain barrier (BBB) dysfunction is important etiological player disorders, and combination therapies...
Purpose: A link between seizure susceptibility, blood–brain barrier (BBB) failure, and the activation of peripheral white blood cells has been recently proposed. However, molecular players involved in this cascade events are unknown. We tested hypothesis that immunosupression by splenectomy or lack perforin, a downstream factor natural killer (NK) cytotoxic T cells, could reduce onset. Methods: Pilocarpine was used to induce seizures adult rats wild-type perforin-deficient mice. Splenectomy...
Objectives/Hypothesis Vocal tremor is a neurologic disorder that can be treated with laryngeal botulinum toxin injections (LBTX). We sought to describe our experience thyroarytenoid and concurrent strap muscle injection. Study Design Retrospective chart review. Methods A review was performed of all patients primary diagnosis vocal LBTX from 2012 through 2017. Results Twenty‐one were included (mean age 69 years, 100% female). Thirteen (62%) had minor component spasmodic dysphonia in addition...
Understand the utility and technique of injection pharyngoplasty with autologous fat for treatment mild to moderate velopharyngeal insufficiency in adults without a history cleft palate.Consecutive case series 11 patients (mean [SD] 41 ± 21 years age) who underwent from 2012 2018 at tertiary care center. Patients were followed mean 8.6 8 months pre versus postoperative evaluations improvement rhinophonia, dysphagia, closure by nasopharyngoscopy (scored: 0, none; 1, mild; 2, moderate; 3,...
Background: Le Fort III osteotomy represents the foundation of surgical correction for midface hypoplasia. One serious complication is severing internal maxillary artery or its branches during osteotome advancement pterygomaxillary dysjunction. This study sought to characterize relevant anatomy infratemporal fossa and as it enters fissure. Methods: Bilateral dissections were performed on 15 fresh, normocephalic adult cadavers (30 hemifaces). Four superficial anatomical measurements surface...
To identify, group and document the surgical management of idiopathic subglottic stenosis (iSGS) in pregnant women among North American centers with expertise treatment airway stenosis.
Introduction: Peripheral angioplasty often fails due to intimal hyperplasia (IH), where contractile smooth muscle cells (SMCs) de-differentiate into proliferative, migratory, and pro-inflammatory synthetic SMCs, leading restenosis. We have formerly shown that potentiation of an MK2 inhibitory peptide (MK2i) via delivery with poly(propyl acrylic acid) (PPAA) can block SMC phenotype switching neointima formation in a transplant model. This work develops strategies for targeted vivo MK2i+PPAA...