A5023686390- Virology and Viral Diseases
- Respiratory viral infections research
- Mental Health Research Topics
- Parvovirus B19 Infection Studies
- COVID-19 Impact on Reproduction
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
- Tuberculosis Research and Epidemiology
- Systemic Lupus Erythematosus Research
- Stress Responses and Cortisol
- Optimism, Hope, and Well-being
- Malaria Research and Control
- Syphilis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Multiple Sclerosis Research Studies
- Zoonotic diseases and public health
- Computational Drug Discovery Methods
- Viral Infections and Vectors
- Immunodeficiency and Autoimmune Disorders
- Insect Pest Control Strategies
- Virus-based gene therapy research
- Peripheral Neuropathies and Disorders
- Histiocytic Disorders and Treatments
Nihon University
2020-2025
Nihon University Itabashi Hospital
2022-2024
Rubella infection (RuV) during early pregnancy is a known cause of congenital rubella syndrome (CRS). However, the mechanisms by which virus crosses placenta and infects fetus are not fully understood. It has been that various kinds cell stresses can occur formation. Previously, we demonstrated low-glucose-induced endoplasmic reticulum stress could drastically enhance RuV in immortalized human first-trimester trophoblast cells. In this study, investigated roles oxidative these Oxidative was...
Cow milk is a nourishing food containing numerous essential nutrients. In Japan, the consumption of cow thought to enhance resistance exhaustion-related diseases. Although several nutrients in milk, such as lactoferrin, are modulate immune cells, mechanisms remain unclear. Recently, immunoregulatory functions food-derived microRNAs or exosomes have been reported. Therefore, we studied effects derived from (CM-Exs) on cells present study. We obtained blood samples healthy adult donors with...
TAFRO syndrome is an inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly. Despite great advancements in research on the last decade, its diagnosis treatment are still challenging for most clinicians because rarity severity. Since initial proposal as a distinct disease entity 2010, two independent diagnostic criteria have been developed. Although these different concept whether subtype...
The COVID-19 vaccine is effective in preventing severe cases of COVID-19. For women, gynecological adverse events, such as menstrual irregularities and irregular bleeding, could be a concern after vaccination. In this study, we investigated events the vaccinated Japanese female population.We conducted survey-based study with health-care workers, including medical doctors nurses, coworkers, university faculty, staff, students, at single school affiliated hospital Japan. We used McNemar's test...
The incidence of infections with nontuberculous mycobacteria (NTM) has been increasing worldwide. emergence multidrug-resistant NTM is a serious clinical concern, and vaccine for not yet developed. We previously developed new recombinant Bacillus Calmette-Guérin (rBCG) encoding the antigen 85B (Ag85B) protein Mycobacterium kansasii-termed rBCG-Mkan85B-which was used together booster immunization plasmid DNA expressing same M. kansasii Ag85B gene (DNA-Mkan85B). reported that...
Rubella virus (RuV) infections in pregnant women, especially first-trimester infections, can lead to congenital rubella syndrome (CRS). However, the mechanisms of fetal RuV infection are not completely understood, and it is observed every woman infected with RuV. As gestational diabetes mellitus a risk factor for viral we investigated possible roles hypoglycemia-related endoplasmic reticulum (ER) stress as key vertical using immortalized human trophoblasts. Low-glucose was induced prior by...
BackgroundVaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial for ending the pandemic of disease 2019 (COVID-19). Currently, cumulative effect booster shots mRNA vaccines on adverse events is not sufficiently characterized.MethodsA survey-based study vaccine was conducted in a Japanese medical institute after third dose Pfizer BNT162b2. Adverse were grouped using network analysis, and heteroscedastic probit model built to analyse events.ResultsThere two...
Congenital rubella syndrome (CRS) results from maternal virus infection in early pregnancy. Abnormal neuroimaging findings have been analyzed a small number of CRS patients the past; however, their clinical significance has poorly addressed. Therefore, we investigated 31 with previous studies. The most common finding was parenchymal calcification, which observed 18 (58.1%). A multivariable logistic regression model showed that it associated psychomotor or mental retardation (p = 0.018),...
Abstract The Asian tiger mosquito, Aedes albopictus , is a common mosquito in East and Southeast Asia, but its habitats have expanded to the American, African Australian continents, Europe many other areas. can transmit some important arboviruses that cause human mortality. To control global spread of this genetic analyses A. populations been undertaken throughout world. In Japan, however, few attempts made characterize population structures these mosquitos. study, adult were sampled from...
Measles is a vaccine-preventable disease but occasionally it poses risk of serious and life-threatening illnesswith high rate communicability if contracted by unvaccinated persons. At the end Edo period (1603–1867) in 1862, major outbreak measles occurred. that time, many ukiyo-e (color woodblock prints) artworks were produced called “measles pictures”, which described how to deal with measles. In present study,we examined 4 prints owned Nihon University Medical Archives. Pictorial motives,...
症例は 16 歳女性．難治性吃逆と嘔吐が 4 週間持続した後，嗄声，四肢の異常感覚，複視，回転性めまいが出現した．MRI では延髄背側に異常信号を認め，血清中抗アクアポリン 抗体陽性が判明し，視神経脊髄炎関連疾患 (neuromyelitis optica spectrum disorder: NMOSD) の最後野症候群 (area postrema syndrome: APS) と診断．ステロイドパルス療法により症状は改善した．NMOSD は小児では比較的稀であるが，小児の難治性の吃逆や嘔吐症例においても NMOSD の APS は重要な鑑別疾患の 1 つと考えられた．