A5015109058- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- RNA regulation and disease
- Mangiferin and Mango Extracts
- Melanoma and MAPK Pathways
- Hedgehog Signaling Pathway Studies
- melanin and skin pigmentation
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
Stanford University
2024
Institute of Biomedical Sciences, Academia Sinica
2022-2023
National Yang Ming Chiao Tung University
2022
Academia Sinica
2022
Centre for DNA Fingerprinting and Diagnostics
2015-2016
A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal the receptor Fms-like 3 (FLT3) upregulated by cooperation transcription factors homeobox A9 (HOXA9) and Meis 1 (MEIS1). Signal peptide-CUB-EGF-like repeat-containing (SCUBE) family proteins have previously been shown act as a co-receptor augmenting signaling activity (e.g., vascular endothelial growth...
CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic leukemia that associated with poor prognosis. We establish model of driven allows the distinction specific changes from those reflect megakaryoblast lineage this leukemia. Using model, we map genome wide binding turn imparts characteristic transcriptional signature. A network transcription factor genes bound and upregulated by are to have downstream effects result dysregulated signaling developmental pathways...