A5100641243- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Synthetic Organic Chemistry Methods
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Analysis
- Chemical synthesis and alkaloids
- Neonatal Health and Biochemistry
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- interferon and immune responses
- Phytochemistry and Biological Activities
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
- Ion Transport and Channel Regulation
- Cancer Mechanisms and Therapy
- PARP inhibition in cancer therapy
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
Academia Sinica
2020-2025
Institute of Biomedical Sciences, Academia Sinica
2020-2024
Shanghai First Maternity and Infant Hospital
2023
State Key Laboratory of Oncogene and Related Genes
2016-2022
Shanghai Jiao Tong University
2016-2022
Chinese People's Armed Police Force
2022
China Pharmaceutical University
2022
Chinese People's Armed Police General Hospital
2022
Shandong University
2021
Shandong Provincial Hospital
2021
A new "dual-mode" chromogenic and fluorescent turn-on probe (2) for the selective sensing of biological thiols is reported. In MeOH–H2O cosolvent at physiological pH 7.40 (MeOH–H2O = 3:7), cleave 2,4-dinitrobenzenesulfonyl group to release chromo- fluorophore merocyanine (3).
Abstract Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negatively regulate hypoxia-induced cell dissemination by inhibiting the HIF-1α/HDAC1/Slug pathway. Daxx directly binds DNA-binding domain Slug, impeding histone deacetylase 1 (HDAC1) recruitment antagonizing Slug E-box binding. This, in turn, stimulates E-cadherin occludin expression suppresses Slug-mediated epithelial–mesenchymal transition (EMT)...
Approximately 75% of breast cancers are estrogen receptor alpha (ERα)-positive and treatable with endocrine therapies, but often patients develop lethal resistant disease. Frequent mutations (10-40%) in the ligand-binding domain (LBD) codons gene encoding ERα (ESR1) have been identified, resulting ligand-independent, constitutively active receptors. In addition, ESR1 chromosomal translocations can occur, fusion proteins that lack LBD entirely unresponsive to all treatments. Thus, identifying...
Abstract Histone methyltransferase MLL4 is centrally involved in transcriptional regulation and often mutated human diseases, including cancer developmental disorders. contains a catalytic SET domain that mono-methylates histone H3K4 seven PHD fingers of unclear function. Here, we identify the PHD6 finger (MLL4-PHD6) as selective reader epigenetic modification H4K16ac. The solution NMR structure MLL4-PHD6 complex with H4K16ac peptide along binding mutational analyses reveal unique...
Background The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) has been proved beneficial for numerous types of cancers, including non-small-cell lung cancer (NSCLC). However, a significant number patients with NSCLC still fail to respond ICB due unfavorable tumor microenvironment. To improve the efficacy, immune-chemotherapy combination pemetrexed, cis/carboplatin pembrolizumab (anti-PD-1) recently approved as first-line treatment in advanced...
Abstract Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, delivering impressive results across various cancers. However, resistance is common, and only a limited number of patients experience lasting responses. This underscores the urgent need to understand mechanisms develop new strategies enhance responsiveness. Here we focus on breast cancer, particularly ER+ which generally poorly immunogenic responds ICB. To address this, analyzed METABRIC cohort's...
Abstract Patients with severe COVID‐19 often suffer from lymphopenia, which is linked to T‐cell sequestration, cytokine storm, and mortality. However, it remains largely unknown how acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) induces lymphopenia. Here, we studied the transcriptomic profile epigenomic alterations involved in production by SARS‐CoV‐2‐infected cells. We adopted a reverse time‐order gene coexpression network approach analyze time‐series RNA‐sequencing data, revealing...
Microcin J25 (MccJ25), a lasso peptide antibiotic with unique structure that resembles the lariat knot, has been topic of intense interest since its discovery in 1992. The precursor (McjA) contains leader and core segment. McjB is protease activated upon binding to leader, McjC converts segment into mature MccJ25. Previous studies suggested these biosynthetic steps likely proceed (nearly) concerted fashion; however, there only limited information regarding structural molecular intricacies...
Three new meroterpenoids, hyrtiolacton A (1), nakijinol F (2), and G (3), along with three known ones, B (4), E (5), dactyloquinone (6), were isolated characterized from a Hyrtios sp. marine sponge collected the South China Sea. The structures determined based on extensive analysis of HRESIMS NMR data, their absolute configurations assigned by combination single-crystal X-ray diffraction electronic circular dichroism analyses. Hyrtiolacton (1) represents an unprecedented meroterpenoid...
Two 11(9 → 10)-abeo-5,10-secosteroids possessing an unprecedented dioxatetraheterocyclic ring system, aspersecosteroids A (1) and B (2), a new ergosteroid, asperflosterol (3), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. Their structures determined by spectroscopic analysis, X-ray diffraction, computational methods. Compounds 1–3 demonstrated inhibitory effects on key pro-inflammatory cytokine production in THP-1 cells. biogenetic pathway with oxidative...
Two rare 6(D)/5(E) ring‐fused meroterpenoids, eupeniacetal A ( 1 ) and B 2 ), three new 1‐methoxy‐hydropreaustinoid A1 3 hydroberkeleyone 4 22‐deoxy‐10‐oxominiolutelide 5 as well five known 22‐deoxyminiolutelide 6 preaustinoid 7 berkeleyone C 8 berkeleyacetal 9 A3 10 have been isolated, through the aid of LC–MS, from sponge‐derived fungus Eupenicillium sp. 6A‐9. The structures these meroterpenoids were elucidated by detailed spectroscopic analysis, comparison with literature data,...
Five new imidazole derivatives (1–5), together with eight related known alkaloids, were isolated from a calcareous marine sponge, Leucetta chagosensis, collected the South China Sea. Their structures fully characterized by spectroscopic methods. Structurally, 1 possesses an unusual skeleton featuring and oxazolone rings linked via nitrogen atom, whereas 2 bears intriguing guanylurea-substituted ring. Compounds 4 5 identified as zinc complexes; they represent metal complex analogues of...
Chemical investigation of an ethanol extract the sponge Agelas mauritiana led to isolation and characterization five new diterpene alkaloids, namely, (−)-8′-oxo-agelasine B (1), (+)-agelasine (2), (+)-8′-oxo-agelasine C (3), agelasine V (4), E (5), along with two known compounds, D (6), (7). The structures these compounds were determined by interpretation spectroscopic data comparison literature properties. Compounds 1 3–5 are second example 8′-oxo-agelasine analogs. 2 7 not only exhibited...
New pyrrolidine alkaloids, preussins C-I (1-7) and (11 R)/(11 S)-preussins J K (8 9), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structures configurations of these elucidated by detailed spectroscopic analysis, modified Mosher's method, comparisons with literature data. These compounds showed strong to moderate inhibitory activity toward IL-6 production in lipopolysaccharide-induced THP-1 cells IC50 values ranging 0.11 22 μM, but inactive against normal...
Chemical investigation on CH2Cl2 extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known (3-10). Their structures were elucidated basis NMR spectroscopic analyses, comparing literature. The cytotoxic activities evaluated against four cancer cell lines, compound 2 showed mild MCF-7, A549, HeLa, PC9 lines IC50 values in range 20.1-45.3 μM.
The precursor ion scanning–supercritical fluid chromatography (PI-SFC) method was applied to explore new methionine sulfoxide-containing cycloheptapeptides, axinellasins A–D (1–4), from the marine sponge Axinella sp. Their structures, including absolute configurations, were elucidated by detailed spectroscopic analyses and X-ray crystallography. total synthesis of 4 completed via an Fmoc solid/solution-phase synthesis. Compounds 1–4 exhibited immunosuppressive effects inhibition T B cell...
A metabolomic approach has been developed for evaluating the therapeutic effects of bioactive components and synergistic efficacy Shexiang Baoxin Pill (SBP) on myocardial infarction (MI) in rats. The MI rats were administered SBP, muscone, cinnamic acid, bufalin, ginsenoside Re, Rb1, cholic borneol, a combined version these (SFSBP). Liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was used to obtain data from rats’ serum. number biomarkers that reversed by...