A5091004441- Advanced Fiber Laser Technologies
- Solid State Laser Technologies
- Laser-Matter Interactions and Applications
- Laser Design and Applications
- Photorefractive and Nonlinear Optics
- Photonic Crystal and Fiber Optics
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Laser-induced spectroscopy and plasma
- Optical Coherence Tomography Applications
- Optical Network Technologies
- Laser-Plasma Interactions and Diagnostics
- Atomic and Molecular Physics
- RNA Research and Splicing
- Cancer-related gene regulation
- Laser Material Processing Techniques
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Advanced X-ray Imaging Techniques
- Porphyrin and Phthalocyanine Chemistry
- Kruppel-like factors research
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Digital Holography and Microscopy
Van Andel Institute
2019-2025
Aerospace Information Research Institute
2022-2025
Chinese Academy of Sciences
2012-2025
University of Chinese Academy of Sciences
2018-2024
Shanghai Institute of Nutrition and Health
2018-2022
Shanghai Institutes for Biological Sciences
2018-2022
Deutsches Elektronen-Synchrotron DESY
2019
Universität Hamburg
2019
The University of Tokyo
2014-2018
Center for Excellence in Molecular Cell Science
2018
Abstract Nonlinear optical (NLO) frequency conversion is commonly used for generating midinfrared (MIR) lasers that offer light sources a variety of applications. However, the low laser damage thresholds NLO crystals so far seriously limit output power MIR lasers. Here, new nonlinear material 4H‐SiC demonstrated producing laser. Broadband radiation ranging from 3.90 to 5.60 μm generated in by phase‐matched difference‐frequency generation first time. The results may open door practically...
Significance Brain aging and neural degenerative diseases are characterized by chronic low-degree inflammation, also known as “inflammaging.” Histone acetylation is a classical mark for active gene expression. Here, using H3K27ac ChIP-seq RNA-seq of human mouse brain samples, we found that, during aging, overactivated inflammation-related genes marked decreased broad gene-body hyperacetylation. Restoring the hyper histone deacetylase inhibitors suppressed such overactivation, implying...
Abstract The transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation growth. Here, we report that forms phase separated condensates in the cell nucleus. separation ability of regulated by autoacetylation relies on its catalytic core components, histone (HAT) domain, autoinhibition loop, bromodomain. sequester chromatin such as H3 tail DNA, are amplified through binding to nucleosome. HAT activity decreased due...
The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated human diseases, particularly cancer. Here, we report on the biological functions of C-terminal region encompassing bromodomain (ASH1LBD), plant homeodomain (ASH1LPHD) finger, bromo-adjacent homology (ASH1LBAH) domain, structurally characterize these domains, describe their mechanisms action, explore functional crosstalk between them. We find that ASH1LPHD recognizes...
Abstract Recurrent gain-of-function mutations in the histone reader protein ENL have been identified Wilms tumor, most prevalent pediatric kidney cancer. However, their pathological significance development and tumorigenesis vivo remains elusive. Here, we generate mouse models mimicking tumor (ENL T ) show that heterozygous mutant expression Six2 + nephrogenic or Foxd1 stromal lineages leads to severe, lineage-specific defects, both resulting neonatal lethality. Six2-ENL kidneys display...
At present, deep ultraviolet (DUV) lasers at the wavelength of fourth harmonics 1 μm (266 nm/258 nm) and 193 nm are widely utilized in science industry. We review generation these DUV by nonlinear frequency conversion processes using solid-state/fiber as fundamental frequency. A laser 258 (FHG) could achieve an average power 10 W with a beam quality M2 < 1.5. Moreover, was obtained sum-frequency (SFG). new concept 193-nm use diamond Raman is also introduced. proof-of-principle experiment...
Understanding and controlling defect in two-dimensional materials is important for both linear nonlinear optoelectronic devices, especially terms of tuning optical absorption. Taking advantage an atomic formed easily by smaller size, molybdenum disulfide nanosheet prepared successfully with a different size gradient centrifugation. Interestingly, size-dependent sulfur vacancies are observed high-resolution X-ray photoelectron spectroscopy, force microscopy, transmission electron microscopy....
A 60-mW solid-state deep ultraviolet (DUV) laser at 193 nm with narrow linewidth is obtained two stages of sum frequency generation in LBO crystals. The pump lasers, 258 and 1553 nm, are derived from a homemade Yb-hybrid employing fourth-harmonic Er-doped fiber laser, respectively. finally, power scaling by 2 mm×2 mm×30 mm Yb:YAG bulk crystal. Accompanied the generated 220-mW DUV 221 193-nm delivers an average 60 mW pulse duration 4.6 ns, repetition rate 6 kHz, ∼640 MHz. To best our...
A narrow-linewidth, high average power deep-ultraviolet (DUV) coherent laser emitting at 193 nm is demonstrated by frequency mixing a Yb-hybrid with an Er-fiber laser. The consists of Yb-fiber lasers and Yb:YAG amplifier. output the 310 mW 6 kHz, which corresponds to pulse energy 51 μJ. To best our knowledge, this highest ever reported for narrow-linewidth light generated combination solid-state fiber mixing. We believe will be beneficial application interference lithography seeding...
Abstract The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain known as a protein-protein interaction that binds to E1A and various transcription factors. Here we show has HAT autoinhibitory function. Truncating at leads hyperactive elevated H3K27 H3K18 acetylation in cells. Mechanistically, cooperates with other neighboring domains maintain active site ‘closed’ state. or binding factors induces conformational change ‘opens’ for...
High-power femtosecond pulses delivered at a high-repetition rate will aid machining throughput and improve signal-to-noise ratios for sensitive measurements. Here we demonstrate Kerr-lens mode-locked Yb:YAG ring-cavity thin-disk oscillator with multi-pass scheme the laser beam. With four passes through thin disk, 175-fs were from an average power of 71.5 W repetition 65.3 MHz. The corresponding intra-cavity peak 110 MW is ample nonlinear conversion into more exotic wavelength ranges. six...
A 1553 nm Er-doped fiber master-oscillator-power-amplifier (MOPA) laser system providing pulses with a 6 kHz repetition rate, 5 ns duration, ~210 μJ energy, ~300 MHz linewidth, and near diffraction limited beam quality, was developed. gain as short 0.7 m in length utilized order to relax the SBS effect. To best of our knowledge, thus generated peak power 40 kW is highest one obtained from single frequency silica laser. The pulse quality verified by conversion periodically poled lithium...
We report a 10 kHz, 10.5 W deep ultraviolet (DUV) laser at 258 nm with pulse duration of 3 ns by fourth-harmonic generation (FHG) in CsLiB6O10 crystal high-conversion efficiency. The fundamental is 1030 35 output power consisting Yb:YAG ceramics thin rod amplifier. M2 the DUV was confirmed to be <1.5. To best our knowledge, this beam quality for higher than generated FHG solid-state laser, as well highest conversion efficiency 31% from infrared so far.
We report a 1.02 W coherent light at 193 nm and 2.15 221 generated by sum-frequency generation in CLBO crystals. The conversion efficiency from to was about 47%. To the best of our knowledge, this is highest average power SFG, respectively. These two DUV lights could be used many applications such as laser machining for their high photon energy features well power. also meets requirements injection-seeding hybrid ArF excimer laser.
Due to their unique properties such as transparency, tunability, nonlinearity, and dispersion flexibility, liquid-core fibers represent an important approach for future coherent mid-infrared light sources. However, the damage thresholds of these are largely unexplored. Here we report on generation soliton-based supercontinua in carbon disulfide (CS2) at average power levels high 0.5 W operating stably a long term (>70 h) without any kind degradation or damage. Additionally, also show stable...
We have been developing a hybrid 193 nm ArF laser system that consists of solid state seeding and an excimer amplifier for power-boosting. The Yb-fiber-solid Er-fiber as fundamentals, one LBO three CLBO crystals frequency conversion. In power amplifier, the seed passes through gain media times, average 110 W is obtained. As demonstration potential applications laser, interference exposure test performed.
In this work, we propose an integrated terahertz mode adapter that couples broadband radiation from free-space to hollow-core fiber with a high conversion efficiency (Gaussian beam-to-
Long bones are generated by mesoderm-derived skeletal progenitor/stem cells (SSCs) through endochondral ossification, a process of sequential chondrogenic and osteogenic differentiation tightly controlled the synergy between intrinsic microenvironment cues. Here, we report that loss TRIM28, transcriptional corepressor, in expands SSC pool, weakens osteochondrogenic potential, endows SSCs with properties ectoderm-derived neural crest (NCCs), leading to severe defects skeletogenesis. TRIM28...
Ultrafast ring-cavity thin-disk oscillators combine high output power with the flexibility of generating either unidirectionally or bidirectionally. Here, we report a Kerr-lens mode-locked Yb:YAG oscillator delivering unidirectional 89-fs pulses by inducing additional spectral broadening nonlinear plates. This is shortest pulse duration for oscillator. Bidirectional mode-locking was also realized. These results lay foundation more efficient generation high-order harmonics at MHz repetition...
High-power, single-frequency lasers are important in the applications of coherent optical communication, Doppler wind lidar, and remote sensing. Here, a 10-kHz, 353-μJ, single-frequency, 574-ns, 1548-nm fiber laser system was demonstrated based on pulse modulation. The 1548-nm, seed with linewidth 1.25 kHz modulated by two acousto-optic modulators (AOMs) into 10-kHz pulsed laser. Two cascaded amplifiers were spliced after AOMs to scale up energy. amplified spontaneous emission (ASE)...
We demonstrate a Kerr-lens mode-locked femtosecond Yb:YAG thin-disk oscillator and investigate the approach to increase optical-to-optical efficiency based on scheme of direct multiple passes laser beam through medium. With twelve thin disk, 266-fs pulses were delivered from with an average power 105.6 W at repetition rate 20 MHz. The corresponding is 31.1%, which is, best our knowledge, highest any pulse duration below 300 fs. This demonstration paves way even more efficient oscillators,...