A5057000156- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Trypanosoma species research and implications
- Neuroscience and Neuropharmacology Research
- Studies on Chitinases and Chitosanases
- Neuroendocrine regulation and behavior
- Muscle Physiology and Disorders
- Legume Nitrogen Fixing Symbiosis
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Neurobiology and Insect Physiology Research
- Heat shock proteins research
- Ion channel regulation and function
- Spaceflight effects on biology
- Infant Nutrition and Health
- Chromosomal and Genetic Variations
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
University of Fribourg
2020-2024
Institute of Genetics and Cancer
2023
Indian Institute of Science Education and Research Mohali
2018
Abstract Maintaining or shifting between behavioral states according to context is essential for animals implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional changes remains poorly understood. Here, we show that C. elegans integrates environmental temperature food availability over different timescales engage in dwelling, scanning, global glocal search strategies matching thermoregulatory...
Animal behavior is critically dependent on the activity of neuropeptides. Reversals, one most conspicuous behaviors in Caenorhabditis elegans , plays an important role determining navigation strategy animal. Our experiments hermaphrodite C. show involvement a neuropeptide FLP-18 modulating reversal length these hermaphrodites. We that controls by regulating AVA interneurons through G-protein-coupled receptors, NPR-4 and NPR-1. go to site action receptors interneuron for ASE sensory neurons...
Abstract Transcriptional enhancers must find their target genes both efficiently and specifically. Chromatin conformation capture revealed the critical function of three-dimensional chromosome segmentation by topologically associated domains (TADs) to limit search space for promoters in mammals. In nematodes, although more than 30’000 sequences with characteristic enhancer chromatin features have been identified, autosomal genome is not segmented TADs, raising question mechanism directing...
Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity nociceptors ethical concerns are challenges for their study in mammalian models. Here, we investigate a single type genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging vivo, demonstrate that FLP encodes thermal information tonic graded manner over wide range spanning from noxious cold to heat...
Sensory and behavioral plasticity are essential for animals to thrive in changing environments. As key effectors of intracellular calcium signaling, Ca 2+ /calmodulin-dependent protein kinases (CaMKs) can bridge neural activation with the many regulatory processes needed orchestrate sensory adaptation, including by relaying signals nucleus. Here, we elucidate molecular mechanism controlling cell activation-dependent nuclear translocation CMK-1, Caenorhabditis elegans ortholog mammalian...
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues executing functions. In contrast, invertebrate a single RyR-encoding it has long been proposed that transcripts generated by alternative splicing may diversify their Here, we analyze the expression function exons C . elegans unc-68 We show specific isoform subsets created via promoters Divergent Region 2 (DR2),...
ABSTRACT Maintaining or shifting between behavioral states according to context is essential for animals implement fitness-promoting strategies. How integration of internal state, past experience and sensory inputs orchestrate persistent multidimensional behavior changes remains poorly understood. Here, we show that C. elegans integrates food availability environment temperature over different timescales engage in dwelling, scanning, global glocal search strategies matching thermoregulatory...
Abstract Many nematodes possess N-glycans with complex core chitobiose modifications, which is a feature observed in various free-living and parasitic but absent mammals. Using Caenorhabditis elegans as model to study N-glycan biosynthesis, we demonstrated that the N -acetylglucosamine (GlcNAc) residues can be modified by three fucosyltransferases Golgi, namely FUT-1, FUT-6 FUT-8. While asparagine-linked GlcNAc α1,3- α1,6-linked fucose FUT-1 FUT-8 respectively, distal residue...