A5070596719- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Youth, Drugs, and Violence
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Phytochemistry Medicinal Plant Applications
- Natural Antidiabetic Agents Studies
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Biological Activities
- Pharmacological Receptor Mechanisms and Effects
- Health and Lifestyle Studies
- Plant-based Medicinal Research
- Health, Nursing, Elderly Care
- Alzheimer's disease research and treatments
- Ziziphus Jujuba Studies and Applications
- Analytical Methods in Pharmaceuticals
- Pharmacology and Obesity Treatment
- Natural product bioactivities and synthesis
- Olfactory and Sensory Function Studies
- Pain Management and Placebo Effect
- Palliative and Oncologic Care
- Palliative Care and End-of-Life Issues
Universidade Federal da Paraíba
2016-2024
Universidade Estadual da Paraíba
2016
Epilepsy is a chronic neurological disorder affecting 1-2% of world population, and one-third patients are refractory to pharmacological treatment. This fact has stimulated research for new antiepileptic drugs natural products have been an important source. trans-Anethole (TAN) phenylpropanoid, component some essential oils, extracted from plants, its effects little studied. Therefore, this study aimed at investigating the TAN effect in classic seizure models evaluate electroencephalographic...
Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants different species, obtained from semisynthesis citronellal, and widely used as fragrance cosmetics. The objective this work was to evaluate the possible anxiolytic-like activity HC its mechanism action using vivo silico methodologies. Swiss male mice (Mus musculus) were treated with (12.5, 25, 50 mg/kg, i.p.) subjected rota rod, elevated plus maze, open field tests. No significant impairments observed rod...
Due to the complex nature of pain and participation physical, cognitive, psychological behavioral aspects, management has several approaches. The use medicinal plants in developing countries is quite expressive. Seeking new options for treatment emerging or debilitating diseases. Therefore, present study seeks elucidate effects monoterpene, citronellal, differentiating its activity by isomers (R)-(+) (S)-(-) citronellal. used methods evaluate citronellal on motor coordination, nociceptive...
Treatment of pain and fever remains an important challenge for modern medicine. Non-steroidal anti-inflammatory drugs (NSAIDs) are the pharmacological options most often used, but their frequent use exposes patient to serious side effects dangerous drug interactions. In this context, thiophene derivatives promising therapeutic alternatives. study, we evaluated in vivo silico antinociceptive antipyretic properties RMD86, a derivative. At 100 mg/kg, RMD86 induced no significant changes motor...
This is a nonclinical, controlled, and triple-blind study to investigate the effects of codeine-associated geraniol on modulation orofacial nociception its potential central nervous system depressing effect in an animal model. The antinociceptive activity combination with codeine was assessed through following tests: (i) formalin-induced pain, (ii) glutamate-induced (iii) capsaicin-induced pain. Six animals were equally distributed into six groups received treatments, given intraperitoneally...
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia inflammation once the prevalence pain population generates great suffering disability drugs most often used have undesirable side We also evaluated whether inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able improve antinociceptive activity EOLp alone. Data were by analysis variance (ANOVA), followed Tukey’s test....
OBJECTIVE: This study traces the therapeutic communities’ interned crack users profile in Paraiba. METHODS: A descriptive with quantitative approach, developed 20 voluntaries. The data collection was conducted through semi structured interview and Anxiety Trace-State Inventory (IDATE-T). RESULTS: are predominantly young adults, single, brown, having high school completed, guided to use due drugs effects’ desire/curiosity. First consumption from 10 19 years old, using period 1 5 daily...
Introduction: palliative care are a type of directed to people with diseases without therapeutic possibility cure, guided by philosophy that emphasizes comprehensive the person, as opposed actions only seek cure. According WHO, seeks quality life both patients and their families, from measures aimed at prevention relief suffering. Objective: verify nursing professionals’ concept on determine how professionals use in possibilities Method: field study, exploratory, qualitative, conducted 30...
Objectives: the following review aims to present accumulated evidence in literature around main human models for induction of anxiety and measures frequently used its evaluation.
 Method: It was made a bibliographic research having as source articles listed by Pubmed Medline databases specific books which have investigated experimental measurements Discussion: Both psychological chemical ethical limits are constituted fundamental links between basic therapeutic tests done with patients....
Objetivo: Avaliar o efeito do óleo essencial de Lavandula angustifolia Mill sobre os parâmetros fis iológicos usuários crack em abstinência. Metodologia: Estudo experimental tipo ensaio farmacológico clínico agudo randômico, duplo-cego, composta por 35 voluntários, sexo masculino, abstinência e sem comorbidades neurológicas e/ou psiquiátricas. Resultados: Os frequência cardíaca (FC) respiratória (FR) apresentaram-se similares entre grupos antes da intervenção, porém, após procedimento...
Anxiety in the world population has increased significantly; problem encouraged studies regarding innovative alternatives for treatment. Research with Citrus aurantium L. essential oil (CEO) revealed positive results anxiolytic effects both animals and humans. However, certain limitations affect its storage preservation, efficiency therapy, determination of adequate posologies. The potential use cyclodextrins as drug carriers been successfully explored. This study aims to assess a...