A5084615389- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Functional Brain Connectivity Studies
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Metalloenzymes and iron-sulfur proteins
- Metal-Catalyzed Oxygenation Mechanisms
- Biocrusts and Microbial Ecology
- Eating Disorders and Behaviors
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Acute Ischemic Stroke Management
- Light effects on plants
- Neural and Behavioral Psychology Studies
- Reproductive tract infections research
- Microbial Community Ecology and Physiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolomics and Mass Spectrometry Studies
- Protist diversity and phylogeny
- Anesthesia and Neurotoxicity Research
- Plant Stress Responses and Tolerance
- Treatment of Major Depression
University of Turku
2014-2024
Turku PET Centre
2019-2024
Turku University Hospital
2019-2023
Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several neuropsychiatric disorders. Central MOR availability also varies considerably healthy individuals. Multiple epidemiological factors proposed to influence system, but due small sample sizes magnitude of their remains inconclusive. We compiled [11C]carfentanil positron emission tomography scans from 204 individuals no neurologic or psychiatric disorders, and estimated effects sex, age, body mass index...
Significance Cyanobacterial flavodiiron proteins (FDPs) comprise a protein family with unique modular structure and photoprotective functions in an oxygenic environment. It is conceivable that FDPs have made the development of photosynthesis possible cyanobacteria. Here, we report ability specific to reduce O 2 directly water heterocyst-forming filamentous cyanobacteria, not only support photosynthetic machinery, but also prevent oxidative damage N -fixing enzyme nitrogenase. Whilst ancient...
The amount of light energy that is harvested and directed to the photosynthetic machinery regulated in order control production reactive oxygen species (ROS) leaf tissues. ROS have important roles as signalling factors instigate mediate a range cellular responses, suggesting mechanisms regulating light-harvesting transduction also affect cell signalling. In this study, we exposed wild-type (WT) Arabidopsis mutants impaired regulation ( stn7 , tap38 npq4 ) transient high (HL) stress study...
The cyanobacterium Synechocystis sp. PCC 6803 (S. 6803) is a well-established model species in oxygenic photosynthesis research and potential host for biotechnological applications. Despite recent advances genome sequencing microarray techniques applied systems biology, quantitative proteomics approaches with corresponding accuracy depth are scarce S. 6803. In this study, we developed protocol to screen changes the expression of 106 proteins representing central metabolic pathways targeted...
Seasonal rhythms influence mood and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no previously reported in vivo evidence. Here, we first conducted cross-sectional study acquired human [11C]carfentanil PET imaging data (132 male 72 female healthy subjects) to test whether there is MOR availability. We then investigated experimentally daylength causally influences...
Chloroplasts play an important role in the cellular sensing of abiotic and biotic stress. Signals originating from photosynthetic light reactions, form redox pH changes, accumulation reactive oxygen electrophile species or stromal metabolites are key importance chloroplast retrograde signaling. These signals initiate plant acclimation responses to both stresses. To reveal molecular activated by rapid fluctuations growth intensity, gene expression analysis was performed with Arabidopsis...
Abstract Eating behavior varies greatly between individuals, but the neurobiological basis of these trait-like differences in feeding remains poorly understood. Central μ-opioid receptors (MOR) and cannabinoid CB 1 (CB R) regulate energy balance via multiple neural pathways, promoting food intake reward. Because obesity eating disorders have been associated with alterations brain’s opioid endocannabinoid signaling, variation MOR R system function could potentially underlie distinct...
Aberrant dopaminergic function is linked with motor, psychotic, and affective symptoms, but studies have typically compared a single patient group healthy controls Here, we investigated the variation in striatal (caudate nucleus, nucleus accumbens, putamen) thalamic type 2 dopamine receptor (D2R) availability using [11C]raclopride positron emission tomography (PET) data from large sample of 437 humans including controls, subjects Parkinson's disease (PD), antipsychotic-naïve schizophrenia,...
The obligate intracellular pathogen Chlamydia pneumoniae remains a difficult target for antimicrobial therapy. Owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well propensity of bacterium persistent infections, treatment failures are common. Despite urgent need new antichlamydial compounds, their discovery is challenged technically demanding assay procedures lack validated targets. An alternative strategy using naturally occurring compounds derivatives...
We announce the draft genome sequence of Calothrix strain 336/3, an N2-fixing heterocystous filamentous cyanobacterium isolated from a natural habitat. 336/3 produces higher levels hydrogen than Nostoc punctiforme PCC 73102 and Anabaena 7120 and, therefore, is interest for potential technological applications.
Abstract The brain’s µ-opioid receptors (MORs) are involved in analgesia, reward and mood regulation. Several neuropsychiatric diseases have been associated with dysfunctional MOR system, there is also considerable variation receptor density among healthy individuals. Sex, age, body mass smoking proposed to influence the but due small sample sizes magnitude of their remains inconclusive. Here we quantified vivo availability brains 204 individuals no neurologic or psychiatric disorders using...
Abstract BACKGROUND The dopamine system contributes to a multitude of functions ranging from reward and motivation learning movement control, making it key component in goal-directed behavior. Altered dopaminergic function is observed neurological psychiatric conditions. Numerous factors have been proposed influence function, but due small sample sizes heterogeneous data analysis methods previous studies their specific joint contributions remain unresolved. METHODS In this cross-sectional...
Abstract Photosystems I and II (PSI PSII) are the integral components of photosynthetic electron transport chain that utilize light to provide chemical energy for CO 2 fixation. In this study, we investigated how deficiency PSII affects gene expression, accumulation, organization thylakoid protein complexes as well physiological characteristics Synechocystis sp. PCC 6803 by combining biochemical, biophysical, transcriptomic approaches. RNA‐seq analysis showed upregulated expression genes...
In acute ischemic stroke (AIS), timely detection and reliable segmentation of AIS lesions on magnetic resonance images (MRIs) are essential for patient selection treatment. Our purpose was to develop validate an innovative knowledge-based automated technique that utilizes diffusion weighted (DWIs) apparent coefficient (ADC) lesions. We developed evaluated our method a large dataset (n=156) including 106 50 healthy controls. The proposed compares DWI ADC the subjects – after MNI space...
Abstract PURPOSE Aberrant dopaminergic function is linked with motor, psychotic, and affective symptoms, but studies have typically compared a single patient group healthy controls. METHODS: Here, we investigated the variation in striatal (caudate nucleus, nucleus accumbens, putamen) thalamic type 2 dopamine receptor (D R) availability using [ 11 C]raclopride positron emission tomography (PET) data from large sample of 437 humans including controls, subjects Parkinson’s disease (PD),...
Abstract Seasonal rhythms influence mood and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no previously reported in vivo evidence. Here, we studied the effects on MOR availability via analysing dataset (n=204) [ 11 C]carfentanil positron emission tomography (PET) scans healthy volunteers. We found that daylength had an inverted U-shaped functional relationship...
Abstract Eating behavior varies greatly between healthy individuals, but the neurobiological basis of these trait-like differences in feeding remains unknown. Central µ-opioid receptors (MOR) and cannabinoid CB 1 -receptors (CB R) regulate energy balance via multiple neural pathways, promoting food intake reward. Because obesity eating disorders have been associated with alterations brain’s opioid endocannabinoid signaling, variation MOR R system function could potentially underlie distinct...