A5054730096- Plant-Microbe Interactions and Immunity
- Sleep and related disorders
- Sleep and Wakefulness Research
- Insect-Plant Interactions and Control
- Plant Molecular Biology Research
- Sleep and Work-Related Fatigue
- Plant Stress Responses and Tolerance
- Plant Parasitism and Resistance
- Polysaccharides and Plant Cell Walls
- Plant tissue culture and regeneration
- Plant pathogens and resistance mechanisms
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Legume Nitrogen Fixing Symbiosis
- Plant Reproductive Biology
- Traffic and Road Safety
- Youth Substance Use and School Attendance
- Urban Transport and Accessibility
- Biofuel production and bioconversion
- Transgenic Plants and Applications
- Plant Pathogens and Resistance
- Circadian rhythm and melatonin
- Psychoanalysis and Psychopathology Research
- Human-Automation Interaction and Safety
- GABA and Rice Research
Royal Holloway University of London
2013-2024
National Centre for Disease Prevention and Control
2019
Sapienza University of Rome
2002-2018
Ollscoil na Gaillimhe – University of Galway
2014
University of Milan
2014
University of East Anglia
2000-2011
Sainsbury Laboratory
1999-2004
John Innes Centre
1999-2004
Università degli Studi della Tuscia
2004
Norwich Research Park
2000
Summary Jasmonates (JAs) regulate Arabidopsis thaliana wound and defence responses, pollen development, stress‐related growth inhibition. Significantly, each of these responses requires COI1, an F‐box protein. Other proteins interact with SKP1 cullin to form SCF complexes that selectively recruit regulatory targeted for ubiquitination. To determine whether COI1 also functions in complex, we have characterized bind COI1. An cDNA expression library was screened yeast clones produce which can...
Abstract Insomnia, the most prevalent sleep disorder worldwide, confers marked risks for both physical and mental health. Furthermore, insomnia is associated with considerable direct indirect healthcare costs. Recent guidelines in US Europe unequivocally conclude that cognitive behavioural therapy (CBT‐I) should be first‐line treatment disorder. Current approaches are stark contrast to these clear recommendations, not least across Europe, where, if any at all delivered, hypnotic medication...
Barley Mlo defines the founder of a novel class plant integral membrane proteins. Lack wild type protein leads to broad spectrum disease resistance against pathogenic powdery mildew fungus and deregulated leaf cell death. Scanning<i>N</i>-glycosylation mutagenesis Mlo-Lep fusion proteins demonstrated that is membrane-anchored by 7 transmembrane (TM) helices such N terminus located extracellularly C intracellularly. Fractionation cells immunoblotting localized plasma membrane. A genome-wide...
The polymorphic barley (Hordeum vulgare) Mla locus harbors allelic race-specific resistance (R) genes to the powdery mildew fungus Blumeria graminis f sp hordei. highly sequence-related MLA proteins contain an N-terminal coiled-coil structure, a central nucleotide binding (NB) site, Leu-rich repeat (LRR) region, and C-terminal non-LRR region. Using transgenic lines expressing epitope-tagged MLA1 MLA6 derivatives driven by native regulatory sequences, we show reversible salt...
Summary To identify components of the defense response that limit growth a biotrophic fungal pathogen, we isolated Arabidopsis mutants with enhanced disease susceptibility to Erysiphe orontii . Our initial characterization focused on three mutants, eds14 , eds15 and eds16 None these is considerably more susceptible virulent strain bacterial pathogen Pseudomonas syringae pv. maculicola ( Psm ). All develop hypersensitive when infiltrated expressing avirulence gene avrRpt2 which activates...
Phytohormones regulate plant growth from cell division to organ development. Jasmonates (JAs) are signaling molecules that have been implicated in stress-induced responses. However, they also shown inhibit growth, but the mechanisms not well understood. The effects of methyl jasmonate (MeJA) on leaf regulation were investigated Arabidopsis (Arabidopsis thaliana) mutants altered JA synthesis and perception, allene oxide synthase coi1-16B (for coronatine insensitive1), respectively. We show...
Plants respond to biotic and abiotic factors in the external environment. These include wounding, pathogen pest attack, changes light temperature. They also internal signals produced during development, such as formation of flowers. responses generally involve re‐programming gene expression. Biotic stress signal perception have commonly been represented three pathways, which can be distinguished by production jasmonates, ethylene or salicylic acid. Each these pathways therefore involves...
Abstract Plant responses to abiotic stresses are dynamic, following the unpredictable changes of physical environmental parameters such as temperature, water and nutrients. Physiological phenotypical stress intercalated by periods recovery. An earlier can be remembered ‘stress memory’ mount a response within generation or transgenerationally. The priming’ phenomenon allows plants respond quickly more robustly stressors increase survival, therefore has significant implications for...
Abstract Polygalacturonase-inhibiting proteins (PGIPs) are extracellular plant inhibitors of fungal endopolygalacturonases (PGs) that belong to the superfamily Leu-rich repeat proteins. We have characterized full complement pgip genes in bean (Phaseolus vulgaris) genotype BAT93. This comprises four clustered members span a 50-kb region and, based on their similarity, form two pairs (Pvpgip1/Pvpgip2 and Pvpgip3/Pvpgip4). Characterization encoded products revealed both partial redundancy...
The endoplasmic reticulum (ER) of eukaryotic cells serves as a checkpoint tightly monitoring protein integrity and channeling malformed proteins into different rescue degradation routes. several ER lumenal membrane-localized is mediated by ER-associated (ERAD) in yeast (Saccharomyces cerevisiae) mammalian cells. To date, evidence for the existence ERAD-like mechanisms plants indirect based on heterologous or artificial substrate proteins. Here, we show that an allelic series single amino...
The powdery mildew resistance genes RPW8.1 and RPW8.2 from Arabidopsis differ the other isolated plant (R) in their predicted protein domains spectrum. two homologous RPW8 encode small proteins featuring a amino-terminal transmembrane anchor domain coiled-coil confer to broad spectrum of mildews. Here, we show that plants expressing have enhanced another biotrophic pathogen, Hyaloperonospora parasitica, raising possibility may function enhance salicylic-acid-dependent basal defenses, rather...
We present GOssTo, the Gene Ontology semantic similarity Tool, a user-friendly software system for calculating similarities between gene products according to Ontology. GOssTo is bundled with six measures, including both term- and graph-based has extension capabilities allow user add new similarities. Importantly, any measure, can also calculate Random Walk Contribution that been shown greatly improve accuracy of measures. very fast, easy use, it allows calculation on genomic scale in few...