Chun Chen

ORCID: 0000-0003-0404-3094
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About
Contact & Profiles
Research Areas
  • Medical Imaging and Analysis
  • Spine and Intervertebral Disc Pathology
  • Musculoskeletal pain and rehabilitation
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Biomarkers in Disease Mechanisms
  • Chemotherapy-induced organ toxicity mitigation
  • Cleft Lip and Palate Research
  • Medical Research and Treatments
  • Microbial metabolism and enzyme function
  • Supramolecular Self-Assembly in Materials
  • Carbohydrate Chemistry and Synthesis
  • Chemical Synthesis and Analysis
  • Metastasis and carcinoma case studies
  • Lung Cancer Treatments and Mutations
  • Craniofacial Disorders and Treatments
  • Click Chemistry and Applications
  • Video Analysis and Summarization
  • RNA Interference and Gene Delivery
  • Bioactive Natural Diterpenoids Research
  • Fibroblast Growth Factor Research
  • Gastric Cancer Management and Outcomes
  • Macrophage Migration Inhibitory Factor
  • Radiomics and Machine Learning in Medical Imaging
  • Recommender Systems and Techniques
  • Cardiovascular Disease and Adiposity

Fujian Medical University
2016-2023

Wenzhou Medical University
2016-2023

First People's Hospital of Yunnan Province
2022

Kunming University of Science and Technology
2022

China Academy of Engineering Physics
2022

Institute of Chemistry, Academia Sinica
2018

First Affiliated Hospital of Wenzhou Medical University
2016-2018

Wenzhou Institute of Technology Testing & Calibration
2018

Purpose: IR-induced pulmonary fibrosis is one of the most severe late complications radiotherapy for lung cancer. It urgently needed to discover a new drug anti-IR fibrosis. Our previous studies have indicated that TPL exhibits both and anti-tumor activities. To reveal mechanism on fibrosis, alveolar macrophages (AMs) were examined effect their axis Nicotinamide adenine dinucleotide phosphate oxidase-reactive oxygen species (NOXes-ROS) myofibroblast activation. Methods Materials: The...

10.1080/15384047.2016.1139229 article EN Cancer Biology & Therapy 2016-03-22

As a chronic inflammatory disease, atherosclerosis (AS) and ischemia events are primarily affected by inflammation in AS. PANoptosis has been implicated many human systemic disorders, including infection, cancer, neurodegeneration, inflammation. On the other hand, little is understood about PANoptosis's function AS.We used consensus clustering to divide GSE100927 dataset into two panoptosis-related subgroups. PANoptosis-associated genes were screened differential analysis weighted gene...

10.2147/jir.s442260 article EN cc-by-nc Journal of Inflammation Research 2023-12-01

Purpose: To demonstrate the potential benefits of T2* relaxation time intervertebral discs (IVDs) regarding detection and grading degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting. Materials Methods: Cervical sagittal T2-weighted, MRI was performed at 61 subjects, covering C2–3 to C6–7. All were morphologically assessed based on Pfirrmann grade, regions interests (ROIs) drawn over mapping. Receiver operating characteristic (ROC) analysis among...

10.1097/md.0000000000004502 article EN cc-by-nc Medicine 2016-11-01

With the development of Mobile Internet, it is possible for people to access their daily portion news over Web with various types terminals connected it. EagleRadio a phonic recommendation system which helps users personalized via mobile Internet. It reads speech synthesizer users. We propose hybrid recommending strategy considering not only user's listening history, but also taking neighbors similar tastes and preferences into account. can track multiple threads interests diversity...

10.1109/cmc.2009.20 article EN 2009-01-01

The study aims to evaluate the value of mandible transection head-side shifting method (MTHSM) by 2-dimensional sonography in screening fetal cleft lip and palate (CLP) during nuchal translucency scans.A total 7,336 fetuses enrolled for first-trimester aneuploidy were included this prospective study. A sequential scanning approach from toward head was used assessment midsagittal, axial, coronal sections. Observe continuity palatal line, upper alveolar ridge, primary palate. All followed...

10.2174/1573405618666220713103500 article EN Current Medical Imaging Formerly Current Medical Imaging Reviews 2022-07-14

Gastric cancer is a highly prevalent and fatal disease. Accurate differentiation between early gastric (EGC) advanced (AGC) essential for personalized treatment. Currently, the diagnostic accuracy of computerized tomography (CT) staging insufficient to meet clinical requirements. Many studies rely on manual marking lesion areas, which not suitable diagnosis.In this study, we retrospectively collected data from 341 patients with at First Affiliated Hospital Wenzhou Medical University. The...

10.3389/fonc.2023.1265366 article EN cc-by Frontiers in Oncology 2023-10-06

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in preparation of numerous naturally occurring molecules; however, studying such reactions difficult due to lack convenient monitoring method. By using thin-layer chromatography conjunction with photolabile linker on resin, we developed simple method solid-phase real time by chromatography. This provides user-friendly protocol examining reaction conditions solid-state syntheses.

10.1055/s-0036-1592008 article EN Synlett 2018-05-08

Paclitaxel<b> (</b>PTX) is capable of aggravating radiation-induced pulmonary fibrosis (RIPF), but the mechanism unknown. Spry2 a negative regulator receptor tyrosine kinase-related Ras/Raf/ERK pathway. This experiment was aimed at exploring whether aggravation RIPF by PTX related to Spry2. The model established with C57BL/6 mice thoracic irradiation, and administered concurrently. Western blot used detect expression level ERK signaling molecules distribution in plasma membrane/cytoplasm....

10.1124/jpet.123.001695 article EN Journal of Pharmacology and Experimental Therapeutics 2023-11-02
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