A5033522636- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Olfactory and Sensory Function Studies
- Infectious Diseases and Mycology
- Antifungal resistance and susceptibility
- Ginger and Zingiberaceae research
- SARS-CoV-2 and COVID-19 Research
- Advanced Chemical Sensor Technologies
- Infection Control and Ventilation
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Cerebral Venous Sinus Thrombosis
- Anesthesia and Sedative Agents
- SARS-CoV-2 detection and testing
- Infection Control in Healthcare
- Oral and Maxillofacial Pathology
- Data-Driven Disease Surveillance
- Dental Radiography and Imaging
- Dermatology and Skin Diseases
- Airway Management and Intubation Techniques
- Cystic Fibrosis Research Advances
Chulalongkorn University
2013-2025
King Chulalongkorn Memorial Hospital
2011-2025
Khon Kaen University
2013
Thai Red Cross Society
2011
Acute invasive fungal rhinosinusitis (AIFR) is a life-threatening disease mainly affecting immunocompromised patients. Early detection therefore key to improving patient survival. To date, there are still no standard clinical criteria for AIFR diagnosis. This study develops predictive model that utilizes presentation and computed tomography (CT) findings diagnose AIFR. A retrospective cohort was conducted on patients with high risk at King Chulalongkorn Memorial Hospital over the past 15...
Background Nasal irrigation is widely used in treating sinonasal diseases. Not only does it remove static secretions and promote mucociliary clearance, but, chronic rhinosinusitis, nasal flush also a potential route for topical drug administration into paranasal sinuses. A clinical study was conducted to investigate how well could reach sinuses with the ostiomeatal units blocked rhinosinusitis. This performed (1) assess ability of douche spray deliver solution rhinosinusitis (2) compare...
Corticosteroids added to high volume saline nasal irrigation have been introduced as a more effective method of delivering corticosteroids the sinuses than sprays. However, information regarding effect this intervention on hypothalamic-pituitary-adrenal (HPA) axis is still limited. To evaluate safety long-term corticosteroid (6 months) in patients with chronic rhinosinusitis (CRS) post endoscopic sinus surgery. Seventeen CRS were included. After undergoing surgery, prescribed budesonide...
Asia-Pacific Burden of Respiratory Diseases (APBORD) was a cross-sectional, observational study examining the burden respiratory disease in adults across 6 countries. This article reports symptoms, healthcare resource utilization (HCRU), work impairment and cost associated with allergic rhinitis (AR), asthma, chronic obstructive pulmonary (COPD), rhinosinusitis Thailand. Consecutive participants aged ≥18 years primary diagnosis AR, COPD, or were enrolled at 4 hospitals Thailand during...
Abstract Objectives/Hypothesis: To evaluate the efficacy of intraoperative mitomycin C (MMC) in endonasal endoscopic dacryocystorhinostomy. Study Design: Randomized controlled trial. Methods: Fifty patients with primary acquired nasolacrimal duct obstruction were enrolled and randomly allocated into treatment control group. The underwent standard dacryocystorhinostomy mucosal flaps or placebo on each ostium size was measured at 3 months, 6 12 months to effect placebo, patency lacrimal...
We aimed to study the effect of alkalinity isotonic nasal saline irrigation on symptoms, mucociliary clearance, patency, and patient's preference in patients with allergic rhinitis (AR).A double-blind, randomized, three-arm crossover study.Patients AR were enrolled. Three kinds irrigations: nonbuffered (pH 6.2-6.4), buffered mild 7.2-7.4), 8.2-8.4) given one at a time, different orders. Patients rinsed their nose 240 ml solution twice daily for 10 days then swapped others. The washout period...
Background In perennial allergic rhinitis (PAR), the skin-prick test (SPT) is a good diagnostic tool to identify specific allergens. A nasal provocation (NPT) used allergens and confirm diagnosis. The aim of this study was determine optimal cutoff values symptom peak inspiratory flow (PNIF) changes after dust-mite NPT for predicting PAR. We also studied relationship symptoms in wheal size SPT. Methods One hundred five patients with underwent Dermatophagoides pteronyssinus assessed by PNIF....
Background Mucociliary function is affected by temperature. Exposure to cold air may impair ciliary beat frequency. While saline nasal irrigation improves in activity, there no evidence supporting the use of heated treating patients with chronic rhinosinusitis. Objective To compare effects room-temperature on mucociliary clearance rhinosinusitis patients. Methods Adult were randomized into two groups receiving either or irrigation. Healthy subjects included as control. Saccharin transit time...
An HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (nasal antibody or NAS) was developed to strengthen COVID-19 management. NAS exhibited potent broadly neutralizing activities with PVNT50 values ranging from 0.0035 3.1997 μg/ml for the following variants of concern (ranked lowest highest): Alpha, Beta, Gamma, ancestral, Delta, Omicron BA.1, BA.2, BA.4/5, and BA.2.75. Biocompatibility assessment showed no potential biological risks. Intranasal...
In perennial allergic rhinitis (PAR), the skin-prick test (SPT) is a good diagnostic tool to identify specific allergens. A nasal provocation (NPT) used allergens and confirm diagnosis. The aim of this study was determine optimal cutoff values symptom peak inspiratory flow (PNIF) changes after dust-mite NPT for predicting PAR. We also studied relationship symptoms in wheal size SPT.One hundred five patients with underwent Dermatophagoides pteronyssinus SPT. assessed by PNIF. score PNIF SPT...
Acute bacterial rhinosinusitis (ABRS) is a subtype of acute (ARS). To prevent excessive antibiotic prescribing, clinical criteria for diagnosing ABRS are presented in two major international guidelines from European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2012) the Infectious Diseases Society America (IDSA2012). This study aims to assess accuracy these criteria.Patients with ARS were recruited. Clinical features collected including discolored nasal discharge, facial pain,...
Surgical landmarks for defining the level of skull base during endoscopic sinus and surgery (ESBS), e.g., middle turbinate, may be distorted by tumor or previous surgery. The orbital floor is a valid fixed anatomic landmark white population, but it not known if its use useful an Asian population.To define ESBS in population to compare relation with between populations.Computed tomographies performed on paranasal sinuses Thai patients were retrospectively assessed. distance nasal four...
Histopathology of ethmoid mucosa versus polyp tissue in diagnosing eosinophilic mucin rhinosinusitis
Background Local allergic rhinitis (LAR) is characterized by chronic with localized nasal response to allergens in the absence of systemic immunoglobulin (IgE)-mediated disease assessed skin prick test (SPT) or specific serum IgE level. Nasal provocation (NPT) gold standard for diagnosis LAR. eosinophilia a known inflammatory marker rhinitis. We hypothesized that can be used as screening tool Objective To determine applicability diagnostic Methods Forty-eight perennial nonallergic (NAR)...
Clinicians rely on clinical presentations to select therapeutic agents for acute bacterial rhinosinusitis. Streptococcus pneumoniae and Haemophilus influenzae are common in Drug resistant require different antibiotics.This study aimed evaluate the associations between features of rhinosinusitis pathogenic bacteria.Sixty-four patients with were enrolled. Clinical including nasal obstruction, discolored discharge, facial pain, smell disturbance, fever laboratory findings collected. The...
We assessed associations of potential factors with orbital complications in acute rhinosinusitis (ARS) patients.An unmatched case-control study.A tertiary referral hospital Thailand.Consecutive outpatients any age severe ARS (visual analog scale ≥ 7) and without complications.Patients were enrolled from January 2013 to December 2018. Forty-three patients (55.8% female, median 45.6, (range 2.0-93.0) years) included, 19 the complicated group 24 uncomplicated group. Patient characteristics...
Objective Intranasal corticosteroids (INCS) are first‐line medications for moderate to severe allergic rhinitis (AR). Patients who have had nasal congestion many years often develop inferior turbinate (IT) hypertrophy. Some patients refractory INCS yet decline receive allergen‐specific immunotherapy. IT reduction is then indicated. There been very few studies evaluating the biomarker changes after in AR. This study aimed determine effect of potassium titanyl–phosphate (KTP) laser surgery on...
BACKGROUND: Low-dose macrolides (LDM) are anti-inflammatory agents with antineutrophilic activity, but patient selection for LDM therapy in treating chronic rhinosinusitis (CRS) is controversial. This study aimed to assess factors which predict responders. METHODOLOGY: A prospective cohort was performed. Patients CRS received roxithromycin (150 mg) once daily 12 weeks. Nasal secretions and serology were collected. Nine predictors response assessed: nasal secretion IgE, IL-5, serum...