A5010530964- Radiation Dose and Imaging
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Effects of Radiation Exposure
- Diet and metabolism studies
- Nutrition and Health in Aging
- Radioactivity and Radon Measurements
- Child Nutrition and Feeding Issues
- Lipoproteins and Cardiovascular Health
- Clinical Nutrition and Gastroenterology
- Obesity and Health Practices
- Physical Activity and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Radiation Therapy and Dosimetry
- Cancer Risks and Factors
- Health disparities and outcomes
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Regulation of Appetite and Obesity
- Infant Nutrition and Health
- Cardiovascular Health and Risk Factors
- Radioactive contamination and transfer
- Carcinogens and Genotoxicity Assessment
- Health, Environment, Cognitive Aging
- Infant Health and Development
BioStrategies (United States)
2020-2025
Social and Scientific Systems (United States)
2024
Neogen (United States)
2024
Healthwise
2023
Vanderbilt University Medical Center
2005-2022
Département Environnement et Agronomie
2022
Michigan United
2014-2021
University of Pennsylvania
2021
Ochsner Medical Center
2019
Menlo School
2016
Summary Mastocytosis is a heterogeneous group of diseases characterized by abnormal proliferation mast cells. Systemic mastocytosis ( SM ), in which cells are present tissues beyond the skin, divided into seven subcategories with varying degrees severity and prognosis. Very little known about epidemiology its subcategories. This retrospective cohort study 548 adults diagnosed 1997–2010 was constructed using linked Danish national health registries. The most common subtype indolent (including...
Background: Improved survival after childhood cancer raises concerns over the possible long-term reproductive health effects of therapies. We investigated whether children female survivors are at elevated risk being born preterm or exhibiting restricted fetal growth and evaluated associations different treatments on these outcomes. Methods: Using data from Childhood Cancer Survivor Study, a large multicenter cohort survivors, we studied singleton live births members 1968 to 2002. Included...
We investigated whether racial disparities in the prevalence of type 2 diabetes exist beyond what may be attributable to differences socioeconomic status (SES) and other modifiable risk factors.We analyzed data from 34331 African American 9491 White adults aged 40 79 years recruited into ongoing Southern Community Cohort Study. Participants were enrolled at community health centers had similar circumstances factor profiles. used logistic regression estimate association between race...
Vitamin D is implicated in a wide range of health outcomes, and although environmental predictors vitamin levels are known, the genetic drivers status remain to be clarified. African Americans group at particularly high risk for insufficiency but date have been virtually absent from studies circulating levels. Within Southern Community Cohort Study, we investigated association between 94 single nucleotide polymorphisms (SNPs) five pathway genes (GC, VDR, CYP2R1, CYP24A1, CYP27B1) serum...
We evaluated the independent and joint effects of race, individual socioeconomic status (SES), neighborhood SES on mortality risk.
Multi-cancer early detection (MCED) next-generation-sequencing blood tests represent a potential paradigm shift in screening.
Menthol cigarettes, preferred by African American smokers, have been conjectured to be harder quit and contribute the excess lung cancer burden among black men in Unites States. However, data showing an association between smoking menthol cigarettes increased risk compared with nonmenthol are limited. The Food Drug Administration is currently considering whether ban sale of United We conducted a prospective study 85 806 racially diverse adults enrolled Southern Community Cohort Study during...
There is limited evidence demonstrating the benefits of physical activity with regard to mortality risk or harms associated sedentary behavior in black adults, so we examined relationships between these health behaviors and cause-specific a prospective study that had large proportion adults. Participants (40–79 years age) enrolled Southern Community Cohort Study 2002 2009 (n = 63,308) were prospectively followed over 6.4 years, 3,613 1,394 deaths occurred blacks whites, respectively. Black...
Updated analyses of mortality data are presented on 46,970 workers employed 1948–1999 at Rocketdyne (Atomics International). Overall, 5,801 were involved in radiation activities, including 2,232 who monitored for intakes radionuclides, and 41,169 engaged rocket testing or other non-radiation activities. The worker population is unique that lifetime occupational doses from all places employment sought, updated incorporated into the analyses. Further, 14 different radionuclides calculated 16...
Although much research has been conducted on the role adult body mass index (BMI) plays in mortality, there have fewer studies that evaluated associations of BMI young adulthood and weight trajectory with it remains uncertain whether differ by race or sex. We prospectively examined relationships (21 years age) obesity later-life mortality rates among 75,881 men women Southern Community Cohort Study. Study participants were enrolled between 2002 2009 at ages 40–79 followed through December,...
The aim of this study was to test the effectiveness OPTIFAST program (OP), a total meal replacement dietary intervention, compared with food-based (FB) plan for weight loss.Participants BMI 30 55 kg/m2 , age 18 70 years old, were randomized OP or FB and lifestyle interventions 26 weeks, followed by weight-maintenance phase. Outcomes percent change in body (%WL) from baseline weeks 52, associated changes composition (using dual energy x-ray absorptiometry), adverse events. Primary analysis...
Abstract Context The hypothalamic melanocortin 4 receptor (MC4R) pathway serves a critical role in regulating body weight. Loss of function (LoF) mutations the MC4R pathway, including pro-opiomelanocortin (POMC), prohormone convertase 1 (PCSK1), leptin (LEPR), orMC4R genes, have been shown to cause early-onset severe obesity. Methods Through comprehensive epidemiological analysis known and predicted LoF variants thePOMC, PCSK1, andLEPR we sought estimate number US individuals with biallelic...
Purpose The study of low dose and low-dose rate exposure is immeasurable value in understanding the possible range health effects from prolonged exposures to radiation. Million Person Study (MPS) was designed evaluate radiation risks among healthy American workers veterans who are more representative today's populations than Japanese atomic bomb survivors exposed briefly high-dose 1945. A million persons were needed for statistical reasons dose-rate effects, rare cancers, intakes radioactive...
Increased sedentary behavior and lack of physical activity are associated with increased risk for many chronic diseases. Differences in leisure-time between African American white adults have been suggested to partially explain racial disparities disease outcomes, but expanding the definition include household occupational activities may reduce or even eliminate differences total activity. The objective this study was describe patterns active behaviors black examine these across demographic...
In recent pooled analyses among whites and Asians, mortality was shown to rise markedly with increasing body mass index (BMI; weight (kg)/height (m)2), but much less is known about this association blacks. This study prospectively examined all-cause in relation BMI 22,014 black males, 9,343 white 30,810 females, 14,447 aged 40–79 years, from the Southern Community Cohort Study, an epidemiologic cohort of largely low-income participants 12 southeastern US states. Participants enrolled 2002...
Polonium-210 is a naturally occurring radioactive element that decays by emitting an alpha particle. It in the air we breathe and also component of tobacco smoke. used as anti-static device printing presses gained widespread notoriety 2006 after poisoning subsequent death Russian citizen London. More known about lethal effects polonium-210 at high doses than late from low doses. Cancer mortality was examined among 7,270 workers Mound nuclear facility near Dayton, OH where (1944–1972)...
Estimates of radiation risks following prolonged exposures at low doses and low-dose rates are uncertain. Medical workers a major component the Million Person Study (MPS) health effects. Annual personal dose equivalents, HP(10), for individual available to facilitate dose-response analyses lung cancer, leukemia, ischemic heart disease (IHD) other causes death.The Landauer, Inc. dosimetry database identified 109,019 medical associated first monitored 1965-1994. Vital status cause death were...
Approximately 235,000 military personnel participated at one of 230 U.S. atmospheric nuclear weapons tests from 1945 through 1962. At the Nevada Test Site (NTS), atomic veterans in maneuvers, observed tests, or provided technical support. Pacific Proving Ground (PPG), they served aboard ships were stationed on islands during after tests.Participants seven test series, previously studied with high-quality dosimetry and records, first TRINITY formed cohort 114,270 male participants traced for...
Background During World War II (WWII), the Manhattan Engineering District established a secret laboratory in mountains of northern New Mexico. The mission was to design, construct and test first atomic weapon, nicknamed 'The Gadget' that detonated at TRINITY site Alamogordo, NM. After WWII, nuclear weapons research continued, became Los Alamos National Laboratory (LANL).Materials methods mortality experience 26,328 workers employed between 1943 1980 LANL determined through 2017. Included...