A5024869149- Exercise and Physiological Responses
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
University of California, Irvine
2021-2023
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation contributes to the development of fibrosis in disease remains unclear. Here, we used single-cell transcriptomics determine molecular attributes dystrophic and healthy macrophages. We identified six clusters unexpectedly found that none corresponded traditional definitions M1 or M2 Rather, predominant macrophage signature was characterized by high expression fibrotic factors, galectin-3 (gal-3) osteopontin...
Despite the well-accepted view that chronic inflammation contributes to pathogenesis of Duchenne muscular dystrophy (DMD), function and regulation eosinophils remain an unclear facet type II innate immunity in dystrophic muscle. We report observation group 2 lymphoid cells (ILC2s) are present skeletal muscle principal regulators during dystrophy. Eosinophils were elevated DMD patients mice along with interleukin (IL)-5, a major eosinophil survival factor was predominantly expressed by ILC2s....