A5102869008- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Pregnancy and preeclampsia studies
- Sepsis Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Gestational Diabetes Research and Management
- Neonatal Health and Biochemistry
- Vascular Malformations and Hemangiomas
- Infant Health and Development
- Prenatal Screening and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Bacterial Infections and Vaccines
- Machine Learning and ELM
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Urological Disorders and Treatments
- Global Maternal and Child Health
- Non-Invasive Vital Sign Monitoring
- Cancer, Hypoxia, and Metabolism
Centre Hospitalier Universitaire de Clermont-Ferrand
2011-2024
Inserm
2007-2024
Centre National de la Recherche Scientifique
2009-2024
Université Clermont Auvergne
2008-2023
Clermont Université
2005-2022
Karolinska University Hospital
2021-2022
Karolinska Institutet
2019-2022
Institut Pascal
2018-2019
Association pour l'Utilisation du Rein Artificiel dans la région Lyonnaise
2019
Genetique Reproduction and Developpement
2010-2011
Abstract Objectives To describe the true incidence, prenatal detection rate and fetal outcome of congenital diaphragmatic hernia (CDH) in a systematically registered population over an 18‐year period to determine any change trends time. Methods This was retrospective study all cases CDH Central‐Eastern France Birth Defects Registry from 1986 2003. All fetuses infants up 1 year age diagnosed with were registered, including miscarriages later than 22 weeks gestation, stillbirths terminations...
Mammalian airways are highly ramified tree-like structures that develop by the repetitive branching of lung epithelium into surrounding mesenchyme through reciprocal interactions. Based on a morphometric analysis epithelial tree, it has been recently proposed complete scheme is specified early in each lineage programme using elementary patterning routines at specific sites and times developing lung. However, coupled dynamics both have overlooked this process. Using qualitative quantitative...
ABSTRACT Objective To assess whether prenatal identification of small‐for‐gestational age (SGA) was associated with lower rates the primary composite outcome stillbirth, death in delivery room or neonatal complications, and secondary outcomes according to gestational at delivery, stillbirth low 5‐min Apgar score. Methods This historical cohort study included women who had a singleton (≥ 32 weeks) between 1994 2011 one 247 French maternity units. We excluded pregnancies terminated medically,...
Congenital diaphragmatic hernia (CDH) is a common life-threatening congenital anomaly resulting in high rates of perinatal death and neonatal respiratory distress. Some the nonisolated forms are related to single-gene mutations or genomic rearrangements, but genetics isolated (60% cases) still remains challenging issue. Retinoid signaling (RA) critical for both diaphragm lung development, it has been hypothesized that subtle disruptions this pathway could contribute CDH etiology. Here we...
Abstract Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate a surgical model, where signaling pathway is not primarily disrupted by agent. created DH fetal rabbits at day 23 gestation, administrated does all trans ‐retinoic acid (ATRA) or vehicle (VHC) intramuscularly for 8 consecutive days and harvested normal operated (DH) fetuses 31 d (n = 7 each group). Normal...
To present longitudinal observations of hyperechoic lung lesions (HLL) in a non-selected population from the time prenatal diagnosis by ultrasound (US) until postnatal surgery.We conducted retrospective study all fetuses diagnosed with an HLL between 1990 and 2005 our Fetal Medicine Unit.We observed 21 cases HLL. Among 17 unilateral lesion, two cyst punctures were attempted on signs fetal compromise. Termination pregnancy (TOP) was performed seven fetuses. Fourteen followed till birth. First...
We report three cases of fetal lobar bronchial atresia referred to our Fetal Medicine Center during the mid-trimester pregnancy over last 15 years. Lobar can mimic a main stem on ultrasound examination as it induces extensive enlargement, major mediastinal shift and eversion diaphragm. It was associated with severe pulmonary hypoplasia in all cases, even though polyhydramnios ascites were absent two. Termination performed at parental request after counseling each necropsy confirmed one or...
Abstract Introduction Lung hypoplasia and pulmonary arterial hypertension in congenital diaphragmatic hernia lead to a high perinatal mortality. Although sustained fetoscopic tracheal occlusion (TO) improves lung development, major side effect is abnormal pneumocyte differentiation. This study evaluated the potential ability of intratracheal retinoic acid (RA) administration reduce adverse effects TO rabbit model hernia. Methods A left defect was created on day 23 time‐dated pregnant...
ABSTRACT Introduction Acute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end‐products (sRAGE) biomarker pulmonary damage processes, with diagnostic and prognostic value syndrome (ARDS). RAGE pathway also implicated the pathogenesis other diseases like asthma, but sRAGE levels remains under‐investigated. Material methods A prospective, observational, analytical study was conducted at Clermont‐Ferrand University Hospital....
We explore the use of traditional and contemporary hidden Markov models (HMMs) for sequential physiological data analysis sepsis prediction in preterm infants. investigate classical Gaussian mixture model based HMM, a recently proposed neural network HMM. To improve we propose discriminative training approach. Experimental results show potential HMMs over logistic regression, support vector machine extreme learning machine.
Cystic lymphatic malformations result from an abnormal embryological development of the structures. Here we report on a case preterm female baby, born at 34 weeks gestation, with voluminous cervicofacial cystic malformation responsible for airway obstruction. An mTOR inhibitor, sirolimus, was started first day life, and combined iterative sclerotherapy procedures. This illustrates safe successful early administration sirolimus in neonate.
Abstract Background Preterm prelabor rupture of membranes (PPROM) before 34 weeks gestation complicates 1% pregnancies and accounts for one-third preterm births. International guidelines recommend expectant management, along with antenatal steroids antibiotics. Up-to-date evidence about the risks benefits administering tocolysis after PPROM, however, is lacking. In theory, reducing uterine contractility could delay delivery reduce prematurity its adverse short- long-term consequences, but it...