Multiresponsive hydrogels, which are smart soft materials that respond to more than one external stimulus, have emerged as powerful tools for biomedical applications, such drug delivery. Within this context and with the aim of eliminating systematic administration antibiotics, special attention is being paid development systems controlled delivery antibiotic topical treatment bacterial infections. In work, an electro-chemo responsive hydrogel able release chloramphenicol (CAM), a broad...

"Smart" materials are gaining widespread attention and popularity due to their innovative ability provide additional functionalities that go beyond the capabilities of traditional materials. Moreover, interesting phenomena surge at transition from microscale nanoscale, where significant changes in properties occur emergence quantum effects. However, these often combine different nature which might be difficult merge. This can solved by use core–shell structures, as they have with an enhanced...

Biosurfactants can replace fossil-driven surfactants with positive environmental impacts, owing to their low eco-toxicity and high biodegradability. However, large-scale production application are restricted by costs. Such costs be reduced using renewable raw materials facilitated downstream processing. Here, a novel strategy for mannosylerythritol lipid (MEL) explores the combination of hydrophilic hydrophobic carbon sources sideways processing strategy, based on nanofiltration technology....

Cancer, namely breast and prostate cancers, is the leading cause of death in many developed countries. Controlled drug delivery systems are key for development new cancer treatment strategies, to improve effectiveness chemotherapy tackle off-target effects. In here, we a biomaterials-based wireless electrostimulation system with potential controlled on-demand release anti-cancer drugs. The composed curcumin-loaded poly(3,4-ethylenedioxythiophene) nanoparticles (CUR/PEDOT NPs), encapsulated...

Cancer cells possess distinct bioelectrical properties, yet therapies leveraging these characteristics remain underexplored. Herein, we introduce an innovative nanobioelectronic system combining a piezoelectric barium titanate nanoparticle core with conducting poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs), designed to modulate cancer cell bioelectricity through noninvasive, wireless stimulation. Our hypothesis is that acting as nanoantennas, BTO@PEDOT NPs convert mechanical inputs...

New pyrazolyl-diamine ligands with acridine derivatives at the 4-position of pyrazolyl ring were synthesized and characterized (L1 L2). Coordination towards fac-[M(CO)3]+ (M = Re, 99mTc) led to complexes fac-[M(CO)3(κ3-L)] (L L1: M Re1, Tc1; L L2: Re2, Tc2). The interaction novel L2) rhenium(I) (Re1 Re2) calf thymus DNA (CT-DNA) was investigated by a variety techniques, namely UV-visible, fluorescence spectroscopy circular linear dichroism. Compounds L1 Re1 have moderate affinity CT-DNA bind...

Several ferrocene derivatives (five mononuclear and two binuclear), including the new N-(p-chlorophenyl)-carboxamidoferrocene (1), were synthesized their anticancer activity investigated. Two of them, 3 7, bearing a benzimidazole backbone most active against HeLa cells achieving IC50 values ~5 μM along with 4 dipyridylamine ligand (~6 μM). Complex 6, also backbone, displayed slightly higher (~11 Cyclic voltammetry studies show that while non-cytotoxic 1, 2, 5 follow ferrocene-based redox...

Different pyrazolyl-diamine ligands bearing anthracenyl or anthrapyrazole functionalities as DNA-binding groups, at different positions of the chelator framework, were labeled with fac-[99mTc(CO)3]+ core. The resulting complexes, 1–4, are highly stable in vitro under physiologic conditions; all them have been identified by high-performance liquid chromatography comparison Re congeners, exception 3, that is anchored an diamine ligand. Aiming to assess ability these complexes target cell...

Aiming to evaluate their potential as radioactive probes for in vivo targeting of melanotic melanoma and its metastases, we have synthesized 99mTc(I) tricarbonyl complexes (Tc1–Tc8) anchored by pyrazolyl-containing chelators with (N3) or (N2O) donor atom sets functionalized 2-aminoethyldiethylamine 4-amino-N-(2-diethylaminoethyl)benzamide groups melanin-binding pharmacophores. The chemical identification the several 99mTc has been accomplished HPLC comparison Re congeners (Re1–Re8), which...

Essential oils from foliage, bark and heartwood of Cryptomeriajaponica D. Don Azores Archipelago (Portugal) were analyzed by GC GC-MS. Two populations, black reddish color, studied. The main compounds found in the foliage both populations alpha-pinene (9.6-29.5%), (+)-phyllocladene (3.5-26.5%), ent-kaur-16-ene (0.2-20.6%), sabinene (0.5-19.9%) limonene (1.4-11.5%), with a large variation individual each population. Heartwood characterized high content cubebol (2.8-39.9%) epi-cubebol...

For functional nitrogen-bridged calix(hetero)aromatic platforms to be further used in the design of more sophisticated receptors, azacalix[2]arene[2]triazine nitrogen bridges were functionalised with methyl bromoacetate. Three new macrocycles four N-methyl ester pendant arms straightforwardly prepared good yields from undecorated precursors chlorine, dimethylamine or dihexylamine substituted triazines. These intermediate exhibited different reactivity towards nucleophilic replacement, which...

A microfluidic based, multiplexed biosensor, for the detection of azelaic, salicylic and jasmonic acid is presented, which may be used to monitor plant health at point need.

Abstract 7,8‐Dihydropyrimido[5,4‐ d ]pyrimidines 4 were isolated in very good yields by treatment of 9‐aryl‐6‐cyanopurines 1 with primary amines. Nucleophilic attack the amine on C8 purine ring was followed ring‐opening imidazole unit, and subsequent intramolecular cyclization involving newly formed amidine group cyano substituent pyrimidine produced 7,8‐dihydropyrimido[5,4‐ ]pyrimidine structure . When ammonia used instead amines, compound rapidly reacted further to afford more stable...

Abstract New [PtCl(pz*NN)] n + complexes anchored by pyrazolyl‐diamine (pz*NN) ligands incorporating anthracenyl or acridine orange DNA‐binding groups have been synthesized so as to obtain compounds that would display synergistic effects between platination and intercalation of DNA. Study their interaction with supercoiled DNA indicated the anthracenyl‐containing complex L 2 Pt displays a covalent type binding, whereas counterpart 3 shows combination intercalative binding modes strong...

The objective of this study is to analyse the impact introducing a practical work in learning process Fluid Transport Systems course Chemical Engineering degree. students, groups two or three elements, were free choose application case order develop proposed by responsible teachers. students selected centrifugal pump supply water houses buildings and designed piping system. was evaluated through written report. students’ perceptions analysed questionnaire. outcomes also considered understand...

This study describes, for the first time, successful incorporation of poly(ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) in Poly(acrylonitrile) (PAN) fibers. While electroconductive PEDOT:PSS is extremely challenging to electrospun into Therefore, PAN, a polymer easy electrospun, was chosen as carrier due its biocompatibility and tunable chemical stability when cross-linked, particularly using strong acids. PAN:PEDOT:PSS blends, prepared from Clevios PH1000, were fibers...

Abstract Cancer cells exhibit unique bioelectrical properties, yet therapeutic strategies exploiting these are still lacking. Herein, we merge a nanobioelectronic system comprising of barium titanate nanoparticle core and poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs) with cancer to modulate bioelectricity. We hypothesize that the BTO@PEDOT NPs act as nanoantenna, transducing mechanical input provided by external ultrasound (US) stimulation into an electrical output, capable...

Diabetes is a metabolic disorder caused by the body's inability to produce or use insulin. Considering figures projected World Health Organization, research on insulin therapy crucial. Hence, we present soft biointerface based thiol-yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option administrate Most importantly, device rendered electroactive incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) conductive moieties precisely...