A5024990005- Endometriosis Research and Treatment
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Electrohydrodynamics and Fluid Dynamics
- Uterine Myomas and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Iron oxide chemistry and applications
- Muscle Physiology and Disorders
- Biochemical and Molecular Research
- Vitamin D Research Studies
- Peptidase Inhibition and Analysis
- Microbial Metabolism and Applications
- Microbial Natural Products and Biosynthesis
- Neuropeptides and Animal Physiology
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Reproductive System and Pregnancy
- Virus-based gene therapy research
- Cancer Cells and Metastasis
Oregon State University
2018-2025
Herein, we report a novel therapy for prostate cancer based on systemically delivered magnetic hyperthermia. Conventional hyperthermia is form of thermal where nanoparticles to sites via intratumoral administration produce heat in the presence an alternating field (AMF). To employ this tumors that are challenging inject intratumorally, designed nanoclusters with enhanced heating efficiency reach after systemic and generate desirable temperatures upon exposure AMF. Our hydrophobic iron oxide...
Abstract Endometriosis is a devastating disease in which endometrial‐like tissue forms lesions outside the uterus. It causes infertility and severe pelvic pain ≈176 million women worldwide, there currently no cure for this disease. Magnetic hyperthermia could potentially eliminate widespread endometriotic but has not previously been considered treatment because conventional magnetic nanoparticles have relatively low heating efficiency can only provide ablation temperatures (>46 °C)...
Abstract Despite notable advancements, the significantly improved yet suboptimal heating efficiency of current magnetic nanoparticles hinders effectiveness systemically delivered hyperthermia in reducing tumor size or halting growth. Addressing this challenge, seed‐and‐growth thermal decomposition method has been developed to synthesize cobalt‐doped iron oxide (Co‐IONPs) featuring a cubical bipyramid morphology, consisting both magnetite and maghemite phases within their nanostructure. They...
Due to the limited heating efficiency of available magnetic nanoparticles, it is difficult achieve therapeutic temperatures above 44 °C in relatively inaccessible tumors during hyperthermia following systemic administration nanoparticles at clinical dosage (≤10 mg kg-1 ). To address this, a method for preparation with ultrahigh capacity presence an alternating field (AMF) presented. The low nitrogen flow rate 10 mL min-1 thermal decomposition reaction results cobalt-doped magnetite (Fe3 O4 )...
In this brief review, we discuss our efforts to validate nanoplatforms for imaging and treatment of endometriosis. We specifically highlight use nonhuman primates primate tissues in effort. Endometriosis is a painful disorder women where endometrium-like tissue exists outside the uterus. There are no reliable, specific, noninvasive diagnostic tests Laparoscopic remains gold standard identifying small endometriotic lesions both monkeys. Visualizing surgically removing microscopic clinical...
Abstract This study presents the first messenger RNA (mRNA) therapy for metastatic ovarian cancer and cachexia‐induced muscle wasting based on lipid nanoparticles that deliver follistatin (FST) mRNA predominantly to clusters following intraperitoneal administration. The secreted FST protein, endogenously synthesized from delivered mRNA, efficiently reduces elevated activin A levels associated with aggressive cachexia. By altering cell phenotype, treatment prevents malignant ascites, delays...
Recently, therapeutics based on mRNA (mRNA) have attracted significant interest for vaccines, cancer immunotherapy, and gene editing. However, the lack of biocompatible vehicles capable delivering to target tissue efficiently expressing encoded proteins impedes development mRNA-based therapies a variety diseases. Herein, we report mRNA-loaded polymeric nanoparticles diethylenetriamine-substituted poly(aspartic acid) that induce protein expression in lungs muscles following intravenous...
Ectopic pregnancy (EP) is the leading cause of maternity-related death in first trimester pregnancy. Approximately 98% ectopic implantations occur fallopian tube, and expedient management crucial for preventing hemorrhage maternal event tubal rupture. Current ultrasound strategies misdiagnose EP up to 40% cases, failure rate methotrexate treatment confirmed exceeds 10%. Here theranostic strategy potential reported using a near-infrared naphthalocyanine dye encapsulated within polymeric...
Abstract Photoacoustic imaging (PAI) has tremendous potential for improving ovarian cancer detection. However, the lack of effective exogenous contrast agents that can improve PAI diagnosis accuracy significantly limits this application. This study presents a novel nanoagent with specific spectral signature be easily distinguished from endogenous chromophores in tissue, allowing high‐contrast tumor visualization. Constructed as 40 nm biocompatible polymeric nanoparticle loaded two...
Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor-associated kinase 4 (IRAK4) a critical modulator inflammation, inhibition its activity with selective drug molecules (IRAK4 inhibitors) represents promising therapeutic strategy for inflammatory disorders. To exploit full potential this treatment approach, carriers efficient delivery IRAK4 inhibitors to inflamed tissues are essential. Herein, first nanoparticle-based...
Pseudo-oligosaccharides are microbial-derived secondary metabolites whose chemical structures contain pseudosugars (glycomimetics). Owing to their high resemblance the molecules of life (carbohydrates), most pseudo-oligosaccharides show significant biological activities. Some them have been used as drugs treat human and plant diseases. Because economic value, efforts put into understanding biosynthesis, optimizing fermentation conditions, engineering metabolic pathways obtain better...
Endometriosis Treatment In article number 2107808, Ov D. Slayden, Oleh Taratula, and co-worker develop an endometriosis therapy based on targeted magnetic nanoparticles that efficiently accumulate in endometriotic lesions following systemic administration, specifically eradicate the disease by generating therapeutic temperatures inside upon exposure to external alternating field.
Ovarian Cancer Treatment In article number 2204436 by Daniel L. Marks, Oleh Taratula, and co-workers, follistatin mRNA delivered lipid nanoparticles targets ovarian cancer clusters dispersed in the peritoneal cavity of mice. When combined with platinum chemotherapy, proposed treatment may allow complete cytoreduction, enhance resilience to iatrogenic burden chemotherapeutic intervention, increase overall survival, minimize chemotherapy-induced muscular atrophy cancer-associated cachexia.