A5015594420- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Digital Mental Health Interventions
- HIV, Drug Use, Sexual Risk
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- Homelessness and Social Issues
- Immune responses and vaccinations
- Substance Abuse Treatment and Outcomes
- Molecular Biology Techniques and Applications
- Educational Games and Gamification
- Protist diversity and phylogeny
- Mind wandering and attention
British Columbia Children's Hospital
2025
University of British Columbia
2010-2025
Delft University of Technology
2011
Recent increases in the production of genomic data are yielding new opportunities and challenges for biologists. Among chief problems posed by next-generation sequencing assembly analyses these large sets. Here we present an online server, http://EvoPipes.net, that provides access to a wide range tools bioinformatic oriented ecological evolutionary The EvoPipes.net server includes basic tool kit including sequence cleaning pipeline (SnoWhite), scaffolded software (SCARF), reciprocal...
Epigenetic modifications such as DNA methylation are both cell type and developmental age specific. Here, we show that the immunological maturation of blood types influences changes from naive cord to fully functional adult blood. Lymphoid cells in showed more variability than suggesting an antigen-dependent lymphoid throughout lifespan. Fewer between were observed myeloid cells, particularly monocytes, which demonstrated least number We also noted differences epigenetic ages by immune...
Primary atopic disorders are a group of inborn errors immunity that skew the immune system toward severe allergic disease. Defining biology underlying these extreme monogenic phenotypes reveals shared mechanisms common polygenic disease and identifies potential drug targets. Germline gain-of-function (GOF) variants in JAK1 cause atopy eosinophilia. Modeling JAK1GOF (p.A634D) variant both zebrafish human induced pluripotent stem cells (iPSCs) revealed enhanced myelopoiesis. RNA-Seq whole...
The structure of a social network as well peer behaviours are thought to affect personal substance use. Where use may create health risks, understanding the contribution networks be valuable for design and implementation harm reduction or other interventions. We examined support people living in precarious housing socially marginalized neighborhood Vancouver, analysed associations between structure, use, supporters' use.An ongoing, longitudinal study recruited 246 participants from four...
Industrial Design originally focused on product development. However, since a decade the attention has extended from design for products to users, experiences and emotions. Recently, several projects have been initiated be used in application area of mental healthcare — ultimately aiming at an improvement patient's Quality Life by improving their emotion regulation. All these involve specific game elements but designed are not necessarily digitally. The share strategy that involves input...
Abstract Background DNA methylation profiling of peripheral blood leukocytes has many research applications, and characterizing the changes in specific white cell types between newborn adult could add insight into maturation immune system. As a consequence developmental changes, profiles derived from cells are poor references for prediction cord data. We thus examined cell-type differences leukocyte subsets blood, assessed impact these on blood. Results Though all showed some patterns stood...