A5091866343- Congenital Anomalies and Fetal Surgery
- Venous Thromboembolism Diagnosis and Management
- Esophageal and GI Pathology
- Atrial Fibrillation Management and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Forecasting Techniques and Applications
- Child and Adolescent Health
- Innovation Diffusion and Forecasting
- Cleft Lip and Palate Research
- Healthcare Policy and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Folate and B Vitamins Research
- Birth, Development, and Health
- Chronic Disease Management Strategies
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Intracerebral and Subarachnoid Hemorrhage Research
- Child Nutrition and Water Access
- Blood Coagulation and Thrombosis Mechanisms
- Wastewater Treatment and Reuse
- Heparin-Induced Thrombocytopenia and Thrombosis
- Craniofacial Disorders and Treatments
University College London
2024-2025
Great Ormond Street Hospital
2024-2025
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
St George's, University of London
2020-2024
Queen Mary University of London
2014-2024
NIHR Great Ormond Street Hospital Biomedical Research Centre
2024
Population Health Research Institute
2022
University of London
2022
St. Thomas Hospital
2008-2020
Abstract Background In-hospital acute resuscitation in trauma has evolved toward early and balanced transfusion with red blood cells (RBC) plasma being transfused equal ratios. Being able to deliver this ratio prehospital environments is a challenge. A combined component, like leukocyte-depleted cell (RCP), could facilitate RBC plasma, while at the same time improving logistics for team. However, there limited evidence on clinical benefits of RCP. Objective To compare RCP versus alone or...
Abstract Background Noonan Syndrome (NS) is a rare multisystemic disorder with heterogeneous phenotypic manifestations. The aim of this study was to analyse rates survival, hospitalisation, surgeries and prescriptions in children born NS the first 10 years life. Methods This multi-centre population-based cohort study. Data on 175 liveborn diagnosed from 11 EUROCAT congenital anomaly registries were linked healthcare databases. Each registry applied common data model standardise run syntax...
Introduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have CA. This paper describes the EUROlinkCAT study, which is investigating health educational outcomes with CAs for first 10 years their lives. Methods analysis EUROCAT European network population-based registries epidemiological surveillance CAs. using infrastructure to support 22 14 countries link data on births...
Compare 30-day mortality among patients receiving the specific reversal agent andexanet alfa versus replacement prothrombin complex concentrate (PCC) in management of direct-acting oral anticoagulant (DOAC)-related bleeds.
OBJECTIVES To investigate the survival up to age 10 for children born alive with a major congenital anomaly (CA). METHODS This population-based linked cohort study (EUROlinkCAT) data on live births from 2005 2014 13 European CA registries mortality data. Pooled Kaplan-Meier estimates were calculated these (77 054 isolated structural anomalies and 4011 Down syndrome). RESULTS The highest of CAs was within infancy, 97.3% (95% confidence interval [CI]: 96.6%–98.1%) 96.9% CI: 96.0%–97.7%) at 1...
Background Congenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes. Objective To quantify burden disease in for children with congenital by assessing risk hospitalisation, number days spent hospital and proportion extended stays (≥10 days). Methods European population-based record-linkage study 11 regions eight countries including (EUROCAT children) without (reference living same regions. The were born between 1995 2014 followed to...
Globally, Down syndrome is the most common chromosomal anomaly, often co-occurring with cardiac or gastrointestinal anomalies. There a lack of robust data on specific healthcare needs children compared to other major congenital To quantify in first year life anomalies large population-based cohort across Europe. The EUROlinkCAT study was multicentre linkage between anomaly registries Europe and hospital mortality databases. Children born 1st January 1997 31st December 2014 were included....
The outcomes of patients developing major bleeding while on oral anticoagulants remain largely unquantified. objectives this study were to: (i) describe the burden hemorrhage associated with all available in terms proportion bleeds which are intracranial hemorrhages, in-hospital mortality and duration hospitalization following bleeding; (ii) identify risk factors for mortality; (iii) compare characteristics between cases treated warfarin direct subgroups atrial fibrillation or venous...
EUROCAT is a European network of population-based congenital anomaly (CA) registries. Twenty-one registries agreed to participate in the EUROlinkCAT study determine if reliable information on survival children born with major CA between 1995 and 2014 can be obtained through linkage national vital statistics or mortality records. Live birth could linked using personal identifiers either their (including records, death hospital records) records only, depending data available within each...
Congenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate accuracy using certificates estimate burden CAs on mortality for children under 10 years old.Children born alive with a major CA between 1 January 1995 31 December 2014, from 13 population-based European registries were linked records up their 10th birthday or 2015, whichever was earlier.In total 4199 neonatal, 2100 postneonatal 1087 deaths in aged 1-9 reported. The underlying...
Abstract Background Congenital anomalies are a major cause of perinatal, neonatal and infant mortality. Objectives The aim was to investigate temporal changes geographical variation in survival children with congenital (CA) different European areas. Methods In this population‐based linkage cohort study, 17 CA registries members EUROCAT, the network for surveillance CAs, successfully linked data on 115,219 live births CAs mortality records. Registries estimated Kaplan–Meier at 28 days 5 years...
Objective To investigate the survival to 10 years of age children with trisomy 13 (T13) and 18 (T18), born 1995–2014. Design Population-based cohort study that linked mortality data on T13 or T18, including translocations mosaicisms, from member registries EUROCAT, a European network for surveillance congenital anomalies. Setting regions in nine Western countries. Patients 252 live births 602 T18. Main outcome measures Survival at 1 week, 4 weeks 1, 5 estimated by random-effects...
Linking routinely collected healthcare administrative data is a valuable method for conducting research on morbidity outcomes, but linkage quality and accuracy needs to be assessed bias as the were not research. The aim of this study was describe rates linking children with without congenital anomalies regional or national hospital discharge databases evaluate matched data. Eleven population-based EUROCAT registries participated in EUROlinkCAT anomaly (reference children) born between 1995...
The purpose of this study was to evaluate the timing first cardiac surgery, number surgeries performed, and 30-day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their 5 years life.
Abstract Objectives To compare 5-year survival rate and morbidity in children with spina bifida, transposition of great arteries (TGA), congenital diaphragmatic hernia (CDH) or gastroschisis diagnosed prenatally those postnatally. Methods Population-based registers’ data were linked to hospital mortality databases. Results Children whose anomaly was (n = 1088) had a lower mean gestational age than postnatally 1698) ranging from 8 days for CDH 4 TGA. the highest infant significant difference...
Summary The lack of antidotes for activated factor X‐inhibitor direct oral anticoagulants ( DOAC s) means that management bleeding consists largely existing supportive therapies. This study aimed to: (i) examine the relative frequency ‐related major in relation to prescriptions over period; (ii) describe presentation and haematological bleeding; (iii) evaluate association between use prothrombin‐complex‐concentrate PCC ) in‐hospital mortality. Over a 3‐year period, 32 UK hospitals submitted...
Children with congenital anomalies often require surgery but data on the burden of for these children are limited.A population-based record-linkage study in Finland, Wales and regions Denmark, England, Italy Spain. A total 91 504 born 1995-2014 were followed to their tenth birthday or end 2015. Electronic linkage hospital databases provided inpatient surgical procedures meta-analyses performed by age groups.The percentage having first year was 38% some differences across 14% also underwent...
SUMMARY Objectives The objectives of this study were to determine: (i) the incidence massive transfusion ( MT ) (defined as ≥5 red‐blood‐cell RBC units within 4 h, and/or ≥10 24 h bleeding) over a 3‐year period; (ii) cause, and mortality rate patients who received (from any cause); (iii) risk factors for death. Background can occur in different clinical settings, yet little is known about its epidemiology/clinical outcomes. Methods Data was extracted using laboratory information management...
Directly standardized rates (DSRs) adjust for different age distributions in populations and enable, say, the of disease between to be directly compared. They are routinely published but there is concern that a DSR not valid when it based on "small" number events. The aim this study was determine value at which should analyzing real data England. Standard Monte Carlo simulation techniques were used assuming events 19 groups (i.e., 0–4, 5–9, ... 90+ years) follow independent Poisson...
Abstract Background Children born with major congenital anomalies (CAs) have lower academic achievement compared their peers, but the existing evidence is restricted to a number of specific CAs. Objectives To investigate outcomes at ages 11 and 16 in children isolated structural CAs Down or Turner syndromes. Methods This population‐based cohort study linked data on approximately 11,000 school‐aged 1994–2004 registered by four regional CA registries England education from National Pupil...