A5029492161- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Plant chemical constituents analysis
- Plant Pathogens and Fungal Diseases
- Botanical Studies and Applications
- Phytochemical compounds biological activities
- Phytochemical Studies and Bioactivities
- Traditional and Medicinal Uses of Annonaceae
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Alkaloids: synthesis and pharmacology
- Antioxidant Activity and Oxidative Stress
- Polyamine Metabolism and Applications
- Drug-Induced Hepatotoxicity and Protection
- Toxin Mechanisms and Immunotoxins
- Chemical synthesis and alkaloids
- Natural Compound Pharmacology Studies
- Complementary and Alternative Medicine Studies
- Biological and pharmacological studies of plants
- Hops Chemistry and Applications
- X-ray Diffraction in Crystallography
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
Université de Lille
2014-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Université d'Artois
2016-2024
Université de Picardie Jules Verne
2022
Institut Charles Viollette
2014-2021
Centre National de la Recherche Scientifique
2016-2020
Polytech Lille
2017-2019
Inserm
2010-2016
Institut Pasteur de Lille
2010-2016
Center for Infection and Immunity of Lille
2016
Primary biological examination of four extracts the leaves and stems Hyptis atrorubens Poit. (Lamiaceae), a plant species used as an antimicrobial agent in Guadeloupe, allowed us to select hydromethanolic extract for further studies. It was tested against 46 microorganisms vitro . active 29 microorganisms. The best antibacterial activity found bacteria, mostly Gram-positive ones. Bioautography enabled isolation identification compounds from this plant: rosmarinic acid, methyl rosmarinate,...
New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains particularly responsible for complicated pathologies that difficult treat due their virulence and the formation of persistent biofilms forming a complex protecting shell. Parasitic infections caused by Trypanosoma brucei Leishmania mexicana also global concern, because mortality low number safe effective treatments. Female inflorescences hop produce...
The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype Lippia alba were investigated. Binding assays performed on two CNS inhibitory targets: benzodiazepine GABA(A) receptors. most active compound was luteolin-7-diglucuronide, with half maximal concentrations (IC(50)) 101 40 microm, respectively. Fifteen tested for their radical scavenging capacities against DPPH. Four the (verbascoside, calceolarioside E, luteolin-7-diglucuronide theveside)...
The antimicrobial activities of 44 methanolic extracts from different parts Iranian indigenous plant species used in traditional medicines Iran were tested against a panel 35 pathogenic and multiresistant bacteria 1 yeast. efficacy was determined using Müller–Hinton agar Petri dishes seeded by multiple inoculator minimal inhibition concentration (MIC) method. 21 most active (MIC < 0·3 mg ml−1 for one or several micro-organisms) submitted to more refined measurement. best antibacterial...
The lack of an efficient agent that does not have the disadvantage low activity (kojic acid), high cytotoxicity, and mutagenicity (hydroquinone), poor skin penetration (arbutin), or stability in formulation (glabridin) led us to continue our research on new antipigmentation/skin-lightening agents. Therefore, natural products can modulate metabolism pigmentation is great interest. Otherwise, malignant melanoma one most aggressive forms cancer, with metastatic potential, currently, there no...
A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of most cited plants among 63 species used treat “infectious” diseases, with a description their medicinal uses. Bibliographical investigations and antimicrobial screening permitted selection botanical Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves were usually mixture rhizomes Curcuma longa infectious diseases such as cystitis. The methanolic plant extracts tested vitro an agar...
Limited success has been achieved in extending the survival of patients with metastatic colorectal cancer (CRC). There is a strong need for novel agents treatment and prevention CRC. Therefore, present study we evaluated antiproliferative pro-apoptotic potential Crataegus azarolus ethyl acetate extract HCT-116 HT-29 human cell lines. Moreover, attempted to investigate signaling pathways that should be involved its cytotoxic effect. The extract-induced growth inhibitory effect was associated...
The study of chemical composition and biological activity unexplored essential oils may open new perspectives on their potential use in facing major health concerns such as drug‐resistant infections. present investigates the antimicrobial effects previously unstudied obtained from genus Eryngium : glomeratum Lam . barrelieri Boiss compositions aerial parts roots both species were studied using GC / MS analytical technics. analysis led to identification 102 compounds totalizing 85 – 94% all...
Three new N1,N5,N10-tris(4-hydroxycinnamoyl)spermidines were isolated from a methanolic root extract of Microdesmis keayana. They identified as N5,N10-di(p-coumaroyl)-N1-feruloylspermidine, N5-(p-coumaroyl)-N1,N10-diferuloylspermidine, and N1,N5,N10-triferuloylspermidine, named keayanidines A, B, C (1–3), respectively. Their structures established by spectral techniques (electrospray mass spectrometry, one- two-dimensional NMR). A 4′,4″,4′′′-trimethylated derivative was prepared methylation...
Three compounds were isolated from Acnistus arborescens, a tree commonly used in South and Central America traditional medicine against several infectious diseases, some of which are caused by fungi. Bioassay-guided fractionation MeOH extract leaves, based on its anti-Pneumocystis carinii activity, led to the isolation 1-3. Mono- bidimensional NMR analyses enabled identification two new withanolides, (20R,22R)-5beta,6beta-epoxy-4beta,12beta,20-trihydroxy-1-oxowith-2-en-24-enolide (1)...
The search of natural immunomodulatory agents has become an area great interest in order to reduce damage the human body. In this study, potential Crataegus azarolus and its isolated hyperoside on mouse lymphocytes macrophages vitro was assessed. effect C. compounds splenocytes proliferation, killer (NK) cytotoxic T (CTL) activities, macrophage-mediated cytotoxicity were assessed by MTT test. Phagocytic activity inhibition nitric oxide (NO) release also evaluated. antioxidant capacity these...
Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. aim of this study was to investigate the cholinesterase inhibitory activity Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl(1→6)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5),...
Les polyphénols, groupe de molécules structures variées, trouvent d'ores et déjà une large utilisation en phytothérapie. Pour autant, leur connaissance est encore imparfaite. Ils suscitent actuellement beaucoup d'intérêt raison du bénéfice qu'ils pourraient apporter termes prévention des maladies liées au vieillissement : infarctus myocarde, cancers, neurodégénératives. Mais on continue s'interroger sur le réel impact action anti-oxydante la santé humaine, biodisponibilité elle-même mal...
A new phenylethanoid glycoside, marruboside, has been isolated from the aerial parts of Marrubium vulgare L. Its structure was established as 3,4-dihydroxy-beta-phenylethoxy-O-[beta-D-apiofuranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1-->3)]-[beta-D-apiofuranosyl-(1-->6)]-4-O-caffeoyl-beta-D-glucopyranoside, on basis spectroscopic evidence.