A5101849306- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis of heterocyclic compounds
- Crystallography and molecular interactions
- Eicosanoids and Hypertension Pharmacology
- Nonlinear Optical Materials Research
- Organic Chemistry Cycloaddition Reactions
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Liver Disease Diagnosis and Treatment
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cancer, Lipids, and Metabolism
- Crystal structures of chemical compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Probiotics and Fermented Foods
- Chemotherapy-induced organ toxicity mitigation
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Parkinson's Disease Mechanisms and Treatments
- Chronic Myeloid Leukemia Treatments
- Fungal Biology and Applications
- Gut microbiota and health
Delta University for Science and Technology
2015-2025
Mansoura University
2023-2024
University of Tabuk
2023-2024
Armed Forces Hospital
2024
Ain Shams University
2024
National Research Centre
2020
Princess Nourah bint Abdulrahman University
2010-2018
Objectives Gastric ulcer (GU) is a prevalent chronic digestive disease affecting about 10% of the world's population leading to gastrointestinal perforation and bleeding. Genistein legume flavonoid with antioxidants, anti-inflammatory antibacterial activities. Therefore, we aimed investigate ability genistein reduce experimentally induced GU in rats by gastric tissue fibrosis Wnt/β-catenin/TGF-β/SMAD4 pathway.Methods Thirty were used. Ten served as control, was twenty using single dose...
Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing need to identify new drugs that can combat resistance. One potential option echinacoside, natural caffeic acid glycoside with antioxidant, anti-inflammatory, antidepressant, and antidiabetic properties. Therefore, we aimed investigate the ability of echinacoside exhibit antitumor activity against rats through ameliorating hepatic...
A new series of adamantane-isothiourea hybrid derivatives, namely 4-arylmethyl (Z)-N′-(adamantan-1-yl)-morpholine-4-carbothioimidates 7a–e and (Z)-N′-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioimidates 8a–e were prepared via the reaction N-(adamantan-1-yl)morpholine-4-carbothioamide 5 N-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioamide 6 with benzyl or substituted bromides, in acetone, presence anhydrous potassium carbonate. The structures synthesized compounds confirmed by 1H-NMR,...
Sodium nitrite, a food preservative, has been reported to increase oxidative stress indicators such as lipid peroxidation, which can affect different organs including the kidney. Here, we investigated toxic effects of oral sodium nitrite on kidney function in rats and evaluated potential protective Nigella sativa oil (NSO).
Purpose: Drug-induced liver injury (DILI) is the most common cause of acute failure. The aim this study was to investigate molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cisplatin (CP)-induced hepatotoxicity theoretically and experimentally. Materials Methods: Thirty-six male Sprague-Dawley (SD) rats were divided into six groups, two them are normal control groups. Liver induced a single dose CP (12 mg/kg i.p) in four one group. Besides injection day 1, groups...
The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione 3 with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol at room temperature yielded the corresponding N-Mannich bases 3-arylaminomethyl-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thiones 4a–l 3-[(4-substituted piperazin-1-yl)methyl]-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thiones 5a–d, respectively. vitro inhibitory activity compounds 5a–d was assessed against pathogenic...
Background and objectives Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with poor prognosis. It currently the second most common cause of cancer-related mortality. Arctiin, compound found in plants commonly used as vegetable Asian countries an ingredient traditional European dishes, possesses various properties, including anti-proliferative, anti-senescence, anti-oxidative, anti-tumor, toxic, anti-adipogenic, anti-bacterial effects. Our study aims to investigate...
Gleevec (imatinib) is an antineoplastic chemotherapeutic agent used in the treatment of many types cancer. The current study was conducted to examine possible modifying effects grape seeds proanthocyandins extract (GSPE) against apoptosis, liver injury and Ki67 alterations induced by male rats. 40 albino rats were equally divided into four groups (First second control GSPE groups; third group fourth treated with GSPE). elevations P53 depletion Bcl2 levels tissues compared group. Liver...
Background: As individuals age, they may develop Alzheimer's disease (AD), which is characterized by difficulties in speech, memory loss, and other issues related to neural function. Cycloastragenol an active ingredient of Astragalus trojanus has been used treat inflammation, aging, heart disease, cancer. Objectives: This study aimed explore the potential therapeutic benefits cycloastragenol rats with experimentally induced AD. Moreover, underlying molecular mechanisms were also evaluated...
The reaction of 1-adamantyl isothiocyanate 4 with the various cyclic secondary amines yielded corresponding N-(1-adamantyl)carbothioamides 5a–e, 6, 7, 8a–c and 9. Similarly, piperazine trans-2,5-dimethylpiperazine in 2:1 molar ratio N,N'-bis(1-adamantyl)piperazine-1,4-dicarbothioamides 10a 10b, respectively. N-(1-adamantyl)-4-ethoxycarbonylpiperidine-1-carbothioamide 8c excess hydrazine hydrate target carbohydrazide 11, addition to 4-(1-adamantyl)thiosemicarbazide 12 as a minor product. 11...
Gastric ulcer (GU) is one of the most critical gastrointestinal tract disorders. Garcinol a polyisoprenylated benzophenone in Garcinia fruit with antioxidant and anti-inflammatory priorities. We aimed to assess protective effects garcinol against GU induced rats. investigated garcinol's on DNA polymerization via mammalian targets rapamycin (mTOR) cyclin D1, cell proliferation proliferating nuclear antigen (PCNA), inflammatory pathway cyclooxygenase-2 (COX2), TNF-α, IL-1β, IL-4 IL10. In our...
Abstract Objectives Diabetic nephropathy (DN) is one of the most important complications diabetes mellitus and it considered as a principal cause for end-stage renal failure. Ganoderma lucidum (GL) has been studied its reno-protective effect against different kidney injury models. The aim our study to investigate mechanisms by which GL can improve consequent inflammation fibrosis. Methods either in low dose (250 mg/kg, i.p.) or high (500 was administered DN rat model, indices were...
Destructive effects of hepatocellular carcinoma (HCC) is enhanced by many cellular mechanisms including activation fibrosis, inflammation and tumor invasion. Therefore, this study was conducted to investigate the therapeutic iCRT14, β-catenin blocker, on HCC. In addition, molecular iCRT14 will be investigated inflammation, fibrosis invasion pathways. After inducting HCC in rats, hepatic tissues were used for determination expression β-catenin, nuclear factor (NF)κB, necrosis (TNF)-α,...
The spectroscopic, solvent effects, reactivity and MD simulations of N'-[(1E)-(2,6-dichlorophenyl-methylidene]adamantane-1-carbohydrazide (DMC) are reported. Solvation free energies DMC in chloroform, ethanol acetonitrile −21.96, −24.39 −12.31 kcal/mol may be better for the solubilization. Electron donating electron accepting powers somewhat lower solution, revealing a certain increase tendency to receiving electrons decrease donate except acetonitrile, which showed slightly higher values...
Emodin is a naturally occurring anthraquinone derivative with wide range of pharmacological activities, including neuroprotective and anti-inflammatory activities. We aim to assess the anticancer activity emodin against hepatocellular carcinoma (HCC) in rat models using proliferation, invasion, angiogenesis biomarkers. After induction HCC, assessment liver impairment histopathology sections were investigated. Hepatic expression both mRNA protein oxidative stress biomarkers, HO-1, Nrf2;...
The reaction of 5-(1-adamantyl)-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. newly synthesized bases were tested for in vitro inhibitory activities against a panel Gram-positive Gram-negative bacteria yeast-like pathogenic fungus Candida albicans. Six compounds showed potent antibacterial activity one more microorganisms, while two exhibited moderate bacteria. None proved to possess...
The reaction of 4-(adamantan-1-yl)-3-thiosemicarbazide 3 with various aromatic aldehydes yielded the corresponding thiosemicarbazones 4a-g. 1-Adamantyl isothiocyanate 2 was reacted 1-methylpiperazine or piperidine to yield N-(adamantan-1-yl)carbothioamides 5 and 6, respectively. latter benzyl substituted bromides S-arylmethyl derivatives 7a-c. Attempted cyclization 1,3-bis(adamantan-1-yl)thiourea 8 chloroacetic acid via prolonged heating thiazolidin-4-one 9 resulted in desulfurization its...