A5027470931- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Electrical and Bioimpedance Tomography
- Radiation Dose and Imaging
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Veterinary Orthopedics and Neurology
- Cervical and Thoracic Myelopathy
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Cell Image Analysis Techniques
- Nuclear Physics and Applications
- Radiation Detection and Scintillator Technologies
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- 3D Shape Modeling and Analysis
- Additive Manufacturing and 3D Printing Technologies
- Cellular and Composite Structures
- Orthopedic Infections and Treatments
- Medical Image Segmentation Techniques
- Mesenchymal stem cell research
- Particle Detector Development and Performance
- Medical Imaging and Analysis
University of Otago
2018-2025
University of Canterbury
2021-2025
Colorado State University
2019-2025
University of Twente
2021
MedTech CoRE
2021
Khalifa University of Science and Technology
2021
European Organization for Nuclear Research
2021
Christchurch Clinical Studies Trust
2018
Abstract Recently developed modular bioassembly techniques hold tremendous potential in tissue engineering and regenerative medicine, due to their ability recreate the complex microarchitecture of native tissue. Here, we a novel approach fabricate hybrid tissue-engineered constructs adopting high-throughput microfluidic 3D strategies. Osteochondral fabrication was adopted as an example this study, because challenges fabricating load bearing osteochondral with phenotypically distinct zonal...
A microplate-based bioreactor was developed to support dual perfusion of parenchymal and barrier tissues for high-throughput microphysiological system (MPS) studies.
Abstract Objective To determine the biomechanical properties of pedicle screw and rod (PSR) constructs alone with an interbody fusion device (PSRIFD) for equine ventral cervical vertebral stabilization. Study design Cadaveric ex vivo analysis. Sample population A total 14 ( n = 14) adult columns. Methods Cervical columns were stabilized by PSR 6) or PSRIFD 5). Three left unaltered as controls. Non‐destructive testing showed kinematic range motion (ROM), compliance, neutral zone each spinal...
Abstract This work presents a proof-of-concept solution designed to facilitate more accurate radiographic feature characterisation in pre-surgical CT/MR volumes. The involves 3D co-location of 2D digital histology slides within ex-vivo , tumour tissue CT Initially, laboratory dissection measurements seed the placement slices corresponding volumes, followed by in-plane point-based registration bone images CT. Validation using six bisected canine humerus datasets indicated plane misalignment...
This study demonstrates the translation of small-bore MARS photon-counting CT technology to live human spectral imaging within a clinical radiation dose level. We used same platform (hardware and software) for acquisition data, image reconstruction, material decomposition visualisation as in CT. Small-bore has been produce promising results fields cancer, bone cartilage health, cardio-vascular diseases. With development large-bore CT, small-animal studies can now be translated humans, sheep,...
Detection of early osteoarthritis to stabilize or reverse the damage articular cartilage would improve patient function, reduce disability, and limit need for joint replacement. In this study, we investigated nondestructive photon-processing spectral computed tomography (CT) quantitative measurement glycosaminoglycan (GAG) content compared destructive histological biochemical assay techniques in normal osteoarthritic tissues. Cartilage-bone cores from healthy bovine stifles were incubated...
This study aims to demonstrate that spectral CT imaging can identify and quantify inflammatory components of unstable plaque such as iron, calcium lipid in phantoms excised human atherosclerotic plaques. Spectral acquisition protocol was optimised using the MARS scanner. A phantom with multiple concentrations ferric nitrate (25, 50, 100, 200 400 mg/ml), hydroxyapatite (104.3, 402.3, 603.3 mg/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The aim is to perform qualitative and quantitative assessment of metal induced artefacts small titanium biomaterials using photon counting spectral CT. energy binning feature some detectors enables the measured spectrum be segmented into low, mid high bins in a single exposure. In this study, solid porous implants submerged different concentrations calcium solution were scanned animal MARS scanner equipped with polyenergetic X-ray source operated at 118 kVp. Five narrow (7-45 keV, 45-55...
This work presents a proof-of-concept solution designed to improve the accuracy of radiographic feature characterisation in pre-surgical CT/MR volumes. The involves 3D co-location 2D digital histology slides within ex-vivo, tumour tissue CT In initial step, laboratory measurements obtained during dissection were used seed placement individual slices corresponding process was completed by aligning bone images using in-plane point-based registration. Six bisected canine humerus datasets...
Innovation in image-guided procedures has been driven by advances robotic Cone Beam Computed Tomography (CBCT) systems. A fundamental challenge for CBCT imaging is metal artifacts arising from surgical tools and implanted hardware. Here, we outline how two universal non-circular orbits, optimized artifact reduction, can be implemented real-time on clinical Demonstrating potential utility, the orbits were during a pedicle screw cervical spine fixation hip arthroplasty performed porcine ovine...
In this study, we identify requirements for a clinically feasible approach to register histology with radiology data which is suitable bone tumours. Orthopaedic oncology as the main treatment tumours has benefited from developments in patient-specific surgical systems, equipment, and computation. This technology relies upon clinical radiology. However, accuracy of identifying tumour margins difficult validate. Three-dimensional registration pre-operative setting could be used improve...
Assessment of disease burden and drug efficacy is achieved preclinically using high resolution micro computed tomography (CT). However, micro-CT not applicable to clinical human imaging due operating at dose. In addition, the technology differences between standard CT prevent direct translation preclinical applications. The current proof-of-concept study presents spectral photon-counting as a clinically translatable, molecular tool by assessing contrast uptake in an <italic...
Treatment failure in cancer is often due to variation tumour characteristics within the same tumour, or across sites, over time. At present, most cancers are staged with imaging; treatment selected, then patient re-imaged see if working. We intend transform that approach by using a novel non-invasive spectral imaging technology together targeted and non-targeted gold nanoparticles measure burden as well drug delivery. In this study, we report CT of four different cell types (ovarian, breast,...
Introduction: Cervical vertebral malformation is a common cause of neurologic deficits. The authors have developed novel cervical stabilization technique utilizing pedicle screws and rod construct with interbody device (PSR). To further validate this understand its true biomechanical properties, we aimed to evaluate nondestructive range motion kinematics. We hypothesize that the PSR will result in reduced ROM compliance.
The aim of the present study is to show that non-invasive MARS imaging can differentiate between infected and healthy pulmonary tissue using an iodine-based contrast agent at high resolution. One C57BL/6J mouse with chronic tuberculosis (TB) was euthanized CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> excised. TB lungs were incubated in 3% iodine solution. Mouse free also excised solution for control purposes. Calibration scanner...
We describe a CMS-Medipix3RX neutron camera developed by adapting and modifying detector readout electronics at the University of Canterbury. The are part MARS x-ray scanner used for imaging applications [1]. cameras will be precise evaluation complex radiation fields in around Compact Muon Solenoid (CMS) on Large Hadron Collider (LHC) CERN. This help to ascertain performance various sub-systems installed cavern as well predict their useful lifetimes. Medipix3RX can deliver real-time images...