Chiara Lowe
A5060991478- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Photoacoustic and Ultrasonic Imaging
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- Electrical and Bioimpedance Tomography
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Nanoplatforms for cancer theranostics
- Advanced Image Fusion Techniques
- Medical Image Segmentation Techniques
- Orthopedic Infections and Treatments
- Machine Learning in Materials Science
- Radioactive element chemistry and processing
- Particle Detector Development and Performance
University of Otago
2018-2023
University of Canterbury
2022
Gastrointestinal (GI) tract is one of the hard-to-reach target tissues for delivery contrast agents and drugs mediated by nanoparticles due to its harsh environment. Herein, we overcame this barrier designing orally ingestible probiotic vectors 'hitchhiking' ultrasmall hafnia (HfO2) (∼1-2 nm) nanoparticles. The minute-made synthesis these accomplished through a simple reduction reaction. These were incubated with bacteria potential health benefits non-specifically taken up their small size....
Emerging multifunctional nanoparticulate formulations take advantage of nano-meter scale size and surface chemistry to work as a therapeutic delivery agent diagnostic tool for non-invasive real-time monitoring using SPCCT imaging technology.
Abstract The early detection of bone microdamages is crucial to make informed decisions about the therapy and taking precautionary treatments avoid catastrophic fractures. Conventional computed tomography (CT) imaging faces obstacles in detecting due strong self‐attenuation photons from poor spatial resolution. Recent advances CT technology as well novel probes can address this problem effectively. Herein, microdamage demonstrated using ligand‐directed nanoparticles conjunction with photon...
The purpose of the present study was to demonstrate an in vitro proof principle that spectral photon-counting CT can measure gold-labelled specific antibodies targeted cancer cells. A crossover performed with Raji lymphoma cells and HER2-positive SKBR3 breast using a MARS scanner. were incubated monoclonal antibody-labelled gold, rituximab (specific antibody cells), trastuzumab (as control); control). calibration vials multiple concentrations nonfunctionalised gold nanoparticles used...
This study demonstrates the translation of small-bore MARS photon-counting CT technology to live human spectral imaging within a clinical radiation dose level. We used same platform (hardware and software) for acquisition data, image reconstruction, material decomposition visualisation as in CT. Small-bore has been produce promising results fields cancer, bone cartilage health, cardio-vascular diseases. With development large-bore CT, small-animal studies can now be translated humans, sheep,...
X-ray photon-counting detector (PCD) offers low noise, high resolution, and spectral characterization, representing a next generation of CT enabling new biomedical applications. It is well known that involuntary patient motion may induce image artifacts with conventional scanning, this problem becomes more serious PCD due to its pitch extended scan time. Furthermore, often comes substantial number bad pixels, making analytic reconstruction challenging ruling out state-of-the-art correction...
Photon-counting CT offers the potential to provide new diagnostic information. In this study, we sought determine interplay between material identification errors, image quality indicators, and radiation doses using photon-counting spectral CT, whether relationship is replicated in scans of mice. Custom-built Perspex phantoms were used measure signal-to-noise ratio (SNR) spatial resolution, dose thermoluminescent dosimeters. A multicontrast calibration phantom containing inserts with...
This study aims to demonstrate that spectral CT imaging can identify and quantify inflammatory components of unstable plaque such as iron, calcium lipid in phantoms excised human atherosclerotic plaques. Spectral acquisition protocol was optimised using the MARS scanner. A phantom with multiple concentrations ferric nitrate (25, 50, 100, 200 400 mg/ml), hydroxyapatite (104.3, 402.3, 603.3 mg/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The aim is to perform qualitative and quantitative assessment of metal induced artefacts small titanium biomaterials using photon counting spectral CT. energy binning feature some detectors enables the measured spectrum be segmented into low, mid high bins in a single exposure. In this study, solid porous implants submerged different concentrations calcium solution were scanned animal MARS scanner equipped with polyenergetic X-ray source operated at 118 kVp. Five narrow (7-45 keV, 45-55...
Images from MARS spectral CT scanners show that there is much diagnostic value using small pixels and good energy data. use energy-resolving photon-counting CZT Medipix3RX detectors measure the of photons on a five-point scale with spatial resolution 110 microns. The information gives material discrimination quantification. 3D reconstruction voxel size 70 We present images pre-clinical specimens, including excised atheroma, bone joint samples, nanoparticle contrast agents along living...
Assessment of disease burden and drug efficacy is achieved preclinically using high resolution micro computed tomography (CT). However, micro-CT not applicable to clinical human imaging due operating at dose. In addition, the technology differences between standard CT prevent direct translation preclinical applications. The current proof-of-concept study presents spectral photon-counting as a clinically translatable, molecular tool by assessing contrast uptake in an <italic...
Treatment failure in cancer is often due to variation tumour characteristics within the same tumour, or across sites, over time. At present, most cancers are staged with imaging; treatment selected, then patient re-imaged see if working. We intend transform that approach by using a novel non-invasive spectral imaging technology together targeted and non-targeted gold nanoparticles measure burden as well drug delivery. In this study, we report CT of four different cell types (ovarian, breast,...
Bone as a functional material could experience various stresses that lead to microdamages. In article number 1904936, Dipanjan Pan and co-workers show targeted hafnia nanoparticles photon counting spectral computed tomography can detect This advanced technology determine signals from bound the hard tissue of bone both in ex vivo model vivo.
The aim of the present study is to show that non-invasive MARS imaging can differentiate between infected and healthy pulmonary tissue using an iodine-based contrast agent at high resolution. One C57BL/6J mouse with chronic tuberculosis (TB) was euthanized CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> excised. TB lungs were incubated in 3% iodine solution. Mouse free also excised solution for control purposes. Calibration scanner...
We describe a CMS-Medipix3RX neutron camera developed by adapting and modifying detector readout electronics at the University of Canterbury. The are part MARS x-ray scanner used for imaging applications [1]. cameras will be precise evaluation complex radiation fields in around Compact Muon Solenoid (CMS) on Large Hadron Collider (LHC) CERN. This help to ascertain performance various sub-systems installed cavern as well predict their useful lifetimes. Medipix3RX can deliver real-time images...
In this article, we propose a slice-based interactive segmentation of spectral CT datasets using bag features method. The data are acquired from MARS scanner that divides up the X-ray spectrum into multiple energy bins for imaging. literature, most existing methods limited to performing specific task or tied particular imaging modality. Therefore, when applying generalized datasets, additional information cannot be sufficiently utilized. We describe new approach circumvents problem by...