A5067098695- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Particle Detector Development and Performance
- Digital Radiography and Breast Imaging
- Photoacoustic and Ultrasonic Imaging
- Nuclear Physics and Applications
- Electrical and Bioimpedance Tomography
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Dental Radiography and Imaging
- Particle physics theoretical and experimental studies
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- AI in cancer detection
- Advanced X-ray Imaging Techniques
- Cardiac Imaging and Diagnostics
- Bone Tissue Engineering Materials
- Advanced Semiconductor Detectors and Materials
- Nanoplatforms for cancer theranostics
- Atomic and Subatomic Physics Research
- Infrared Thermography in Medicine
- COVID-19 diagnosis using AI
- Geochemistry and Geologic Mapping
University at Buffalo, State University of New York
2023-2025
University of Canterbury
2015-2024
University of Otago
2015-2024
Canterbury District Health Board
2008-2024
European Organization for Nuclear Research
2014-2023
Christchurch Hospital
2004-2022
MedTech CoRE
2021
Khalifa University of Science and Technology
2021
University of Twente
2021
University of Hong Kong
2020
The energy spectrum of X-ray photons after passage through an absorber contains information about its elemental composition. Thus, tissue characterisation becomes feasible provided that absorption characteristics can be measured or differentiated. Dual-energy CT uses two spectra enabling material differentiation by analysing material-dependent photo-electric and Compton effects. Elemental concentrations thereby determined using three-material decomposition algorithms. In comparison to...
X-ray micro-CT is an important imaging tool for biomedical researchers. Our group has recently proposed a hybrid "true-color" system to improve contrast resolution with lower cost and radiation dose. The incorporates energy-resolved photon-counting true-color detector into conventional configuration, can be used material decomposition. In this paper, we demonstrate interior color-CT image reconstruction algorithm developed system. A compressive sensing-based statistical tomography method...
The energy information acquired using spectral X-ray detectors allows noninvasive identification and characterization of chemical components a material. To achieve this, it is important that the response detector calibrated. established techniques for calibration are not practical routine use in pre-clinical or clinical research environment. This due to requirements monochromatic radiation sources such as synchrotron, radio-isotopes, prohibitively long time needed set up equipment make...
Purpose: To determine the potential of spectral computed tomography (CT) with Medipix3 for quantifying fat, calcium, and iron in soft tissues within small animal models surgical specimens diseases such as fatty liver (metabolic syndrome) unstable atherosclerosis. Methods: The spectroscopic method was applied to tomographic data acquired using a micro‐CT system incorporating detector array silicon sensor layer microfocus x‐ray tube operating at 50 kVp. A 10 mm diameter perspex phantom...
Gastrointestinal (GI) tract is one of the hard-to-reach target tissues for delivery contrast agents and drugs mediated by nanoparticles due to its harsh environment. Herein, we overcame this barrier designing orally ingestible probiotic vectors 'hitchhiking' ultrasmall hafnia (HfO2) (∼1-2 nm) nanoparticles. The minute-made synthesis these accomplished through a simple reduction reaction. These were incubated with bacteria potential health benefits non-specifically taken up their small size....
Emerging multifunctional nanoparticulate formulations take advantage of nano-meter scale size and surface chemistry to work as a therapeutic delivery agent diagnostic tool for non-invasive real-time monitoring using SPCCT imaging technology.
A key process in the development of atherosclerotic plaques is recruitment monocytes into artery wall. Using spectral photon-counting computed tomography we examine whether monocyte deposition within wall ApoE-/- mouse can be detected. Primary were labelled by incubating them with 15 nm gold nanoparticles coated 11-mercaptoundecanoic acid The uptake particle was confirmed electron microscopy cells before injection 6-week-old apolipoprotein E deficient (ApoE-/-) that had been fed Western diet...
This study presents a hybrid microfiltration technology designed for high-performance lead (Pb(II)) remediation, especially from aqueous solutions with high Pb(II) concentrations, by utilizing two-dimensional (2D) Ti3C2Tx-MXene layers deposited on dry mycelium membranes. The Ti3C2Tx-MXene/mycelium (MyMX) membranes were fabricated via single-step electrochemical deposition (ECD) technique, which enabled uniform coating of 2D onto individual hyphal fibers prefabricated membrane. Optimized ECD...
Abstract This work presents a proof-of-concept solution designed to facilitate more accurate radiographic feature characterisation in pre-surgical CT/MR volumes. The involves 3D co-location of 2D digital histology slides within ex-vivo , tumour tissue CT Initially, laboratory dissection measurements seed the placement slices corresponding volumes, followed by in-plane point-based registration bone images CT. Validation using six bisected canine humerus datasets indicated plane misalignment...
The MARS research group has created a new version of their scanner for taking improved spectral CT datasets. This the (MARS-CT-3) taken first Medipix3 images phantom. MARS-CT-3 incorporates gantry, x-ray sources and readout board, as well ability to connect gas lines specimen. gantry mechanical rigidity can perform scans faster. Magnification be controlled by moving detector source independently. brighter means six times Gas allow user control various environmental factors inside scanner,...
Spectral molecular imaging is a new technique able to discriminate and quantify different components of tissue simultaneously at high spatial energy resolution. Our MARS scanner an x-ray based small animal CT system designed be used in the diagnostic range (20–140 keV). In this paper, we demonstrate use scanner, equipped with Medipix3RX spectroscopic photon-processing detector, fat, calcium, water tissue. We present data collected from sample lamb meat including bone as illustrative example...
This paper discusses methods for reducing beam hardening effects and metal artefacts using spectral x-ray information in biomaterial samples. A small-animal scanner was operated the 15 to 80 keV energy range this study. We use photon-processing features of a CdTe-Medipix3RX ASIC charge summing mode reduce associated artefacts. present data collected alloy samples, its analysis algebraic 3D reconstruction software volume visualisation custom rendering software. The cupping effect streak are...
A: This work demonstrates the feasibility of simultaneous discrimination multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT.We used CT scanner with four energy thresholds to measure various concentrations iodine (9, 18 36 mg/ml), gadolinium (2, 4 8 mg/ml) gold agents, calcium chloride (140 280 water.We evaluated imaging performances different threshold schemes between 25 82 keV at 118...
Abstract The early detection of bone microdamages is crucial to make informed decisions about the therapy and taking precautionary treatments avoid catastrophic fractures. Conventional computed tomography (CT) imaging faces obstacles in detecting due strong self‐attenuation photons from poor spatial resolution. Recent advances CT technology as well novel probes can address this problem effectively. Herein, microdamage demonstrated using ligand‐directed nanoparticles conjunction with photon...
Utilizing metal nanoprobes with unique K-edge identities to visualize complementary biological activities simultaneously can provide valuable information about complex processes. This study describes the design and preparation of an innovative pair demonstrates feasibility their simultaneous quantitative detection using spectral photon-counting computed tomography (SPCCT). Glycosaminoglycan (GAG) capped nanoparticles (ca. 15-20 nm) targeting two distinct components cartilage tissue, namely,...