A5010541581- Physics of Superconductivity and Magnetism
- Glycosylation and Glycoproteins Research
- Pain Management and Placebo Effect
- Superconductivity in MgB2 and Alloys
- Prenatal Screening and Diagnostics
- Thyroid Disorders and Treatments
- Pain Mechanisms and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Blood groups and transfusion
- Copper-based nanomaterials and applications
- Galectins and Cancer Biology
- Infrared Thermography in Medicine
- Helicobacter pylori-related gastroenterology studies
- Advanced Chemical Physics Studies
- Neutropenia and Cancer Infections
- High-pressure geophysics and materials
- Eicosanoids and Hypertension Pharmacology
- Erythrocyte Function and Pathophysiology
- HIV/AIDS drug development and treatment
- Graphene research and applications
- Magnetic and transport properties of perovskites and related materials
- HIV Research and Treatment
- Sarcoma Diagnosis and Treatment
- ZnO doping and properties
- Monoclonal and Polyclonal Antibodies Research
Fujifilm (Japan)
2019-2025
Nagoya Medical Center
2008-2009
National Hospital Organization
2008-2009
Kawasaki Medical School
2002-2009
Kagoshima City Hospital
2004
Toray Industries, Inc. (Japan)
1990-1996
Tohoku University
1968-1995
College of Medical Sciences
1989-1995
Toray (United States)
1991-1992
The University of Tokyo
1985
We previously found that artificial glycosphingolipids (artGSLs) containing very-long-chain fatty acids behave as strong immunogens in mice and promote the production of antibodies recognizing oligosaccharide portion artGSLs epitope. Here, we report structure influences these immunogenic properties. evaluated antibody-inducing activity with different structures IgG-inducing only an artGSL a core-fucosylated tetraoligosaccharide (Manβ1,4GlcNAcβ1,4[Fucα1,6]GlcNAc). To characterize properties...
Background: The measurement of serum thyroglobulin (Tg) is widely used as a marker for recurrence thyroid carcinoma following total thyroidectomy. However, this method cannot differentiate between benign and malignant disease. We focused on the sugar chain in Tg molecule investigated usefulness Lens culinaris agglutinin (LCA)-reactive ratios sera wash fluids obtained during fine-needle aspiration (FNA) detection carcinoma.
We studied the emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) with major amino acid mutations in 402 therapy-naive patients at Nagoya Medical Center, Japan, between 1999 and 2006. The mean prevalence HIV-1 was 6.7% (range, 2.3-10.0%; n = 27). variants protease inhibitor (PI)-resistant alone were most frequently found (3.5%, 14), followed by those nonnucleoside reverse transcriptase (NNRTI)-resistant (1.7%, 7). Variants nucleoside (NRTI)-resistant sporadically (1.0%,...
Background Inflammatory bowel disease (IBD) is a chronic, relapsing inflammation of the digestive tract. Although fecal and serum biomarkers have been extremely important supportive for monitoring IBD, their low sensitivity high variability characteristics limit clinical efficacy. Thus, establishment better expected. Fucosylation one most glycosylation modifications proteins. Fucosylated haptoglobin (Fuc-Hpt) used as biomarker several cancers inflammation-related diseases. We recently...
Abstract Biosynthesis of carotenoids and steroids in tissue cultures carrot cells I Da ucus carota L.) was studied by measuring the change their contents incorporation 14l C‐acelate. The rate synthesis these plant products varied significantly during growth cycle batch culture. Carotenoids were most actively synthesized early logarithmic phase synthetic sharply declined as culture aged, whereas accumulation phytosterols highest at end phase. Newly carotenes shown to undergo turnover growth....
To monitor active HIV-1 transmission in Nagoya, Japan, we have been determining the subtypes of infecting therapy-naive individuals who newly visited Nagoya Medical Center since 1997. The were determined by phylogenetic analyses using base sequences three regions genes including gag p17, pol protease (PR) and reverse transcriptase (RT), env C2V3. Almost all from 1997 to 2007 93% isolates subtype B. A, C, D, F detected sporadically 1997, almost Africans South Americans. first circulating...
Early detection is urgently needed to improve the patient's pancreatic ductal adenocarcinoma (PDAC) survival. Previously, we identified a novel tumor-associated glycan, H-type3, which expressed on PDAC cells and detected by rBC2LCN (recombinant N-terminal domain of BC2L-C from Burkholderia cenocepacia) lectin. Here, that SERPINA3 an rBC2LCN-reactive glycoprotein (BC2-S3) secreted into blood in patients with liquid chromatography-tandem mass spectrometry analysis lectin blotting. In immune...
Background. The mechanisms of the increase in percentage alpha‐fetoproteins (AFPs) that strongly binds to Lens culinaris agglutinin (AFP‐L3) pregnancies with a trisomy 21 fetus have not been analyzed. To investigate oligosaccharide variants AFP produced by normal fetuses and 21, lectin reactivity was Methods. Fetal liver tissue, amniotic fluid, maternal serum were obtained from five fetus. percentages reactive lectins determined lectin‐affinity electrophoresis coupled antibody‐affinity...
It is generally believed that the lower grade of differentiation glycoprotein-producing cells, more often modification by bisecting N-acetylglucosamine (GlcNAc) or fucose (Fuc) at sugar chain glycoprotein increase in branching side chains occurs. We examined characteristics alpha-fetoprotein (AFP) stored amniotic and exocoelomic fluid during 5-9 weeks gestation analyzed serum-derived AFP patients with germ cell tumors.Total concentrations embryonic (n = 11) serum tumors 7) were measured...
Rat-liver chromatin was digested with micrococcal nuclease at low ionic strength in the presence of a concentration CaCl2. The digest successfully separated into three fractions, P1, P2, and P3, by gel filtration on column Sepharose 2B. P1 fraction shown to be mixture long fragments partially sedimentation profile or electrophoresis DNA. P2 contained four histones H2A, H2B, H3, H4 almost equal amounts, together nonhistone protein molecular weight. DNA composed less than 300 base pairs long....