A5006264565- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Erythropoietin and Anemia Treatment
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Cellular transport and secretion
- Blood disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune cells in cancer
- Central Venous Catheters and Hemodialysis
- S100 Proteins and Annexins
- Dialysis and Renal Disease Management
- Platelet Disorders and Treatments
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2022-2025
Guangdong Academy of Medical Sciences
2022-2025
South China University of Technology
2019-2022
Temple University
2014
Sepsis is a common critical condition that can lead to multiple organ injury. Sepsis-induced acute respiratory distress syndrome (ARDS) frequently an important cause of poor prognosis and associated with high mortality rates, despite existing therapeutic interventions. Neutrophil infiltration extracellular traps (NET) are implicated in lung injury (ALI) ARDS following sepsis. As circulating neutrophils infiltrate infected tissues, they come into direct contact vascular endothelial cells...
ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation thrombus. Deficiency of caused by either genetic mutations or inhibitory autoantibodies against leads thrombotic thrombocytopenic purpura (TTP). Recently, was reported adopt "closed" conformation lower activity an "open" one resulting from the engagements VWF D4-CK domains antibodies distal ADAMTS13, in...
Activation of integrins is crucial for recruitment flowing leukocytes to inflammatory or injured vascular sites, but their spatiotemporal characteristics are incompletely understood. We discovered that β2-integrin activation over the entire surface neutrophils on immobilized P-selectin occurred via mitogen-activated protein kinase (MAPK) non-MAPK signaling with a minute-level timescale in force-dependent manner. In flow, MAPK required intracellular Ca2+ release activate integrin within 2...
Platelet adhesion and activation through the interaction of von Willebrand factor (VWF) with platelet glycoprotein (GP) Ibα are early key events in hemostasis thrombosis especially under high blood shear stress. P-selectin translocation from α granule to cell surface is a typical function phenotype, which makes platelet-induced inflammatory response flowing leukocytes possible can be induced by either chemical agonists (thrombin, ADP, etc.) or stress, but regulations VWF mutation stress on...
The effect of neutrophil extracellular traps (NETs) on promoting intravascular microthrombi formation and exacerbating the severity sepsis in patients has gained extensive attention. However, sepsis, mechanisms key signaling molecules mediating NET during direct interactions endothelial cells neutrophils still need further explored. Herein, we utilized lipoteichoic acid (LTA), a component shared by Gram-positive bacteria, to induce extrusion from firmly adhered glass slides coated with...
Extracellular traps released by neutrophils (neutrophil extracellular traps, NETs) are a double-edged sword, and understanding the mechanism of NET formation is great significance for disease treatment. However, short lifespan, large individual differences, inability to perform gene editing render it difficult decipher using neutrophils. It necessary find model cell replace study formation. In this study, we used different concentrations (0, 0.1, 1, 10 μmol/L) all-trans retinoic acid (ATRA)...
Background: Vascular access dysfunction associated with arteriovenous grafts and fistulas contributes significantly to the morbidity mortality of end-stage renal disease (ESRD) patients receiving hemodialysis. The mechanism involved in development peri-anastomotic intimal hyperplasia, a major cause dysfunction, is poorly elucidated. We hypothesized that uremic condition ESRD promotes pathophysiological vascular smooth muscle cell (VSMC) phenotype accelerated hyperplasia blood vessels, both...