A5055515110- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Spinal Hematomas and Complications
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Barrier Structure and Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Kruppel-like factors research
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Cancer Research and Treatments
- Telomeres, Telomerase, and Senescence
- Bone and Joint Diseases
- RNA regulation and disease
- Spinal Fractures and Fixation Techniques
- Neurological disorders and treatments
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibroblast Growth Factor Research
- Multiple Sclerosis Research Studies
- MRI in cancer diagnosis
Affiliated Hospital of Guizhou Medical University
2016-2025
Guiyang Medical University
2013-2025
Shaanxi University of Chinese Medicine
2023
Anhui Medical University
2017
Fourth Affiliated Hospital of Anhui Medical University
2017
Nanyang Medical College
2010-2014
Huashan Hospital
2013-2014
Fudan University
2013-2014
Guizhou Cancer Hospital
2013
Tianjin Medical University
2006
Objective: The neutrophil‐to‐lymphocyte ratio (NLR) is an important marker of inflammation. An increased NLR has been detected in the blood patients with epilepsy. However, correlation between varying NLRs and epileptic seizures (ESs) still unclear. Methods: A retrospective analysis was conducted, were divided into two groups based on whether they had ES upon admission. Comprehensive data collected, including routine tests, demographic information, medical histories. calculated by dividing...
Intracranial post-operative re-haemorrhage is an important complication in patients with hypertensive intracerebral haemorrhage (ICH). The purpose of the present study was to determine value computed tomography (CT) blend sign predicting ICH. A total 126 ICH were included study. All underwent standard stereotactic minimally invasive surgery(MIS) remove within 24 h following admission. There 41 a on initial CT and 85 without CT. Multivariable logistic regression analyses performed assess...
Abstract Aims Synaptic vesicle protein 2A (SV2A) is a unique therapeutic target for pharmacoresistant epilepsy (PRE). As seizure‐induced neuronal programmed death, parthanatos was rarely reported in PRE. Apoptosis‐inducing factor (AIF), which has been implicated parthanatos, shares common cytoprotective function with SV2A. We aimed to investigate whether participates PRE and mitigated by SV2A via AIF. Methods An intraperitoneal injection of lithium chloride‐pilocarpine used establish an...
The objective of this study was to investigate the effects Rosiglitazone (RSG) infusion therapy following minimally invasive surgery (MIS) for intracerebral hemorrhage(ICH) evacuation on perihematomal secondary brain damage as assessed by MMP-9 levels, blood-brain barrier (BBB) permeability and neurological function.A total 40 male rabbits (2.8-3.4 kg) randomly assigned a normal control group (NC group; 10 rabbits), model (MC treatment (MIS rabbits) or combined MIS RSG + rabbits). ICH...
To observe the relationship between perihematomal glutamate levels and blood–brain barrier (BBB) permeability in a rabbit model of intracerebral hemorrhage (ICH). Seventy-two rabbits were randomly divided into an (ICH) group normal control (NC) group, each 36 was subsequently 6, 12, 18, 24, 48 72 h groups (n = 6 each). An ICH induced by stereotactic injection autologous, arterial, non-anticoagulated blood basal ganglia. The same procedures performed NC but not injected. sacrificed at...
To observe the effects of minimally invasive removal intracerebral hematoma on perihematomal matrix metalloproteinase (MMP)-9 expressions and permeability blood-brain barrier (BBB).Twenty-four rabbits 2.8-3.4 kg body weight (regardless male female) were selected randomly divided into a control group group, model intracranial hemorrhage (ICH) was established in two groups by injecting fresh autologous non-anticoagulant blood brain basal ganglia rabbits. The procedures for performed 6 hours...
Abstract Objective: To observe the effect of minimally invasive removal intracranial hematoma in basal ganglia on cortical spinal tract (CST). Methods: Twenty-seven patients with intracerebral hemorrhage (ICH) were selected and divided into a treatment group (13 patients) medical (14 randomly: volume was 30–50 ml, an average 39.20 ± 4.85 ml 38.70 6.33 group. All underwent whole brain diffusion tensor imaging (DTI) 1 week after onset; fractional anistropy (FA) values CST internal capsule...
Introduction: The effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage (ICH) on perifocal MMP-9 expression and blood–brain barrier (BBB) permeability were evaluated.Methods: Thirty-six rabbits randomly distributed into normal control group (NC group, six rabbits), model (MC (MI 24 rabbits). A ICH was established in the MC MI groups. In hematoma evacuated by stereotactic procedures over 6 hours (six 12 18 following successful induction ICH....
The purpose of this study was to provide pathophysiological evidence for the time window minimally invasive (MI) procedures evacuating intracerebral hematoma by observing perihematomal glutamate level and its correlation with outcome patients treated MI surgery.One hundred consecutive hemorrhage (ICH) in basal ganglia were assigned either a medical treatment group (MT group, 20 patients) or (MI 80 patients). evacuated using stereotactic surgery within 6 hours, 12 18 24 hours symptom onset...
Background Endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood-brain barrier (BBB) integrity. Highly expressed ET-1 was observed after intracerebral hemorrhage (ICH); however, changes their relationship with BBB disruption within 24 hours of ICH have not been thoroughly investigated. The aim the present study to observe in perihematomal levels various phases correlation integrity a rabbit model ICH. Methods Twenty-five rabbits (3.2–4.3 kg body weight)...
Introduction:To determine the effects of minimally invasive surgery (MIS) at various stages after intracerebral hemorrhage (ICH) on perihematomal endothelin (ET)-1 levels and neurological functioning. Methods: Sixty rabbits were randomly distributed into a model control group (MC group, 30 rabbits) or MIS (MI rabbits). An ICH was established in all animals. In MI evacuated by 6, 12, 18, 24, 48 hours (six each time point) established. The animals MC underwent same procedures for evacuation,...
Objectives: To observe the effects of minimally invasive surgery (MIS) for intracerebral hematoma (ICH) evacuation followed by rosiglitazone infusion therapy on peroxisome proliferator-activated receptor-gamma (PPARγ), blood–brain barrier (BBB) permeability, and neurological function.Methods: A total 75 male rabbits (2.8–3.4 kg) were randomly assigned to a normal control group (NC group), model (MC (RSG treatment (MIS group) or MIS combined with (MIS+RSG group). ICH was induced in all...
Abstract Background The initial CT blend sign is an imaging marker that has been used to predict haematoma expansion and poor outcomes in patients with small-volume intracerebral haemorrhage (ICH). However, the association of undergoing surgery remains unclear. present study aimed retrospectively evaluate influence on short-term hypertensive ICH after stereotactic minimally invasive (sMIS). Methods We enrolled 242 spontaneous ICH. were assigned group (91 patients) or non-blend (control) (151...