A5041687656- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Pluripotent Stem Cells Research
- Renal and related cancers
- Infant Nutrition and Health
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal and fetal brain pathology
- Injury Epidemiology and Prevention
- Anesthesia and Neurotoxicity Research
- Reproductive System and Pregnancy
- Telomeres, Telomerase, and Senescence
- Climate Change and Health Impacts
- Early Childhood Education and Development
- Gestational Diabetes Research and Management
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Neurodevelopmental Disorders
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
Universidade de São Paulo
2013-2025
Johns Hopkins Medicine
2024
Lieber Institute for Brain Development
2020-2024
Johns Hopkins University
2020-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2022
Abstract Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation cord blood 39 32 males born at term appropriate weight birth regarding their potential connection outcomes. Mothers were interviewed gather information about environmental factors (gestational exposure) that could interfere profiles newborns. Bisulphite converted was hybridized...
ABSTRACT Introduction Interpersonal violence against women is a major global health problem that may have intergenerational effects. This study investigated associations between maternal experiences of interpersonal and other traumatic events infant salivary diurnal cortisol in cohort adolescent mothers São Paulo, Brazil. Method Adolescent (14–19 years) participating home‐visiting intervention were interviewed retrospectively about lifetime pregnancy trauma exposure. Mothers collected saliva...
This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers trajectories executive functions language development in first 3 years life. 557 mother-infant dyads (mean age mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline are currently collecting data for other timepoints. A linear regression was used predict Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple...
Increased maternal blood concentrations of leptin and decreased adiponectin levels, which are common disturbances in obesity, may be involved offspring adiposity by programming fetal adipose tissue development. The aim this study was to assess the relationship between newborn adiposity. This a cross-sectional involving 210 healthy mother-newborn pairs from public maternity hospital São Paulo, Brazil. Maternal samples were collected after delivery measured enzyme-linked immunosorbent assay....
Primary human trophoblast stem cells (TSCs) and TSCs derived from pluripotent (hPSCs) can potentially model placental processes in vitro. Yet, the states factors involved differentiation of hPSCs to remain poorly understood. In this study, we demonstrate that primed state generate by activating pathways such as Epidermal Growth Factor (EGF) Wingless-related integration site (WNT), suppressing tumor growth factor beta (TGFβ), histone deacetylases (HDAC), Rho-associated protein kinase (ROCK)...
This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers trajectories executive functions language development in first 3 years life. 557 mother-infant dyads (mean age mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline are currently collecting data for other timepoints. A linear regression was used predict Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple...
Abstract Background Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) might translate intrauterine exposures into phenotypic changes a sex-specific manner. DNAm specific sites can also predict newborn gestational age acceleration (GAA). GAA occurs when predicted biological is higher than chronological age. In adults, poor health outcomes related this deviance are well documented raise...
Maternal prenatal psychosocial stress is associated with adverse hypothalamic-pituitary-adrenal axis (HPAA) function among infants. Although the biological mechanisms influencing this process remain unknown, altered DNA methylation considered to be one potential mechanism. We investigated associations between maternal psychological distress, infant salivary methylation, and physiology at 12 months. Mother's distress was measured via depression anxiety in early late pregnancy a cohort of 80...
Background Gestational diabetes mellitus (GDM) is a common complication of pregnancy. It may predispose offspring to increased fat mass (FM) and the development obesity, however few data from Latin America exist. Objective To investigate influence GDM on newborn FM in mother-newborn pairs recruited public maternity care center São Paulo, Brazil. Methods Data were collected cross-sectionally 2013–2014 72 mothers diagnosed with GDM, 211 normal glucose tolerance (NGT). Newborn was evaluated by...
The crosstalk between maternal stress exposure and fetal development may be mediated by epigenetic mechanisms, including DNA methylation (DNAm). To address this matter, we collect 32 cord blood samples from low-income Brazilian pregnant adolescents participants of a pilot randomized clinical intervention study (ClinicalTrials.gov, Identifier: NCT02807818). We hypothesized that the association infant neurodevelopmental outcomes at 12 months age would DNAm. First, searched genome differences...
The neurodevelopment of the offspring is suggested to be influenced by maternal immune system's responses throughout pregnancy, which in turn also vulnerable psychosocial stress conditions. Therefore, our main goal was investigate whether peripheral immunological biomarkers (IB) during two stages gestation are associated with distinct neurodevelopmental trajectories first years life. As a second goal, we explored association between distal (childhood) and proximal (gestation) stressful...
Obesity is associated with lower concentrations of vitamin D [25(OH)D3] in children, adolescents and adults, but it remains unclear whether maternal adiposity influences foetal this vitamin. The objective cross-sectional study was to assess the relationship between cord blood D. It involved 101 mother–newborn pairs from a public maternity Sao Paulo city, Brazil. Demographic, socioeconomic obstetric data, as well anthropometry, physical activity supplementation during pregnancy, were...
Abstract The human placenta is increasingly a focus of research related to early child development and the impact maternal hyperimmune states. Primary trophoblast stem cells (hTSC) pluripotent (hPSC) differentiated hTSC can potentially model placental processes in vitro . Yet, it remains controversial how differentiation trophectoderm relates vivo factors required for this differentiation. Here, we demonstrate that primed state retains potency generate by activating EGF WNT inhibiting TGFb,...
Objectives:Maternal prenatal psychosocial stress is associated with adverse hypothalamic-pituitary-adrenal axis function among infants. While the biological mechanisms influencing this process remain unknown, altered DNA methylation considered to be one potential mechanism. We investigated associations between maternal psychological distress, infant salivary and physiology at 12 months. Methods:Mother’s distress was measured via depression anxiety in early late pregnancy a cohort of 80...