A5088549484- Cardiac Valve Diseases and Treatments
- Family Dynamics and Relationships
- Protease and Inhibitor Mechanisms
- Research in Social Sciences
- Work-Family Balance Challenges
- Intergenerational Family Dynamics and Caregiving
- Lipoproteins and Cardiovascular Health
- Urban, Neighborhood, and Segregation Studies
- Attachment and Relationship Dynamics
- Birth, Development, and Health
- Online Learning and Analytics
- Bayesian Methods and Mixture Models
- Mental Health Research Topics
- Angiogenesis and VEGF in Cancer
- Employment and Welfare Studies
- Infective Endocarditis Diagnosis and Management
- Opinion Dynamics and Social Influence
- Complement system in diseases
- Gender, Labor, and Family Dynamics
- Maternal Mental Health During Pregnancy and Postpartum
- Cognitive Abilities and Testing
- Spatial and Panel Data Analysis
- Advanced Clustering Algorithms Research
- Pulmonary Hypertension Research and Treatments
- Populism, Right-Wing Movements
University of Turku
2019-2024
University of Jyväskylä
2012-2024
National University of Ireland, Maynooth
2024
University of Eastern Finland
2024
University of Geneva
2024
University of Helsinki
2023
Humboldt State University
2023
VIVE - The Danish Center for Social Science Research
2023
University of Twente
2023
Linköping University
2017-2019
This article marks the occasion of Social Science Research's 50th anniversary by reflecting on progress sequence analysis (SA) since its introduction into social sciences four decades ago, with focuses developments SA thus far in and potential future directions. The application sciences, especially life course research, has mushroomed last decade a half. Using analogy, we examined birth childhood (the first wave), adolescence young adulthood second mature paper. paper provides summary (1)...
There is a paucity of longitudinal studies in online learning across courses or throughout programs. Our study intends to add this emerging body research by analyzing the trajectories interaction between student engagement and achievement over full four-year program. We use analytics life-course methods how are intertwined such relationship evolves program for 106 students. findings have indicated that association varies students progresses differently groups time. results showed at any...
Extensive angiogenesis and invasion of the maternal decidua by trophoblasts are essential for development function placenta. Vascular endothelial growth factors (VEGF), placenta factor (PlGF) their receptors VEGFR-1/Flt-1, VEGFR-2/KDR VEGFR-3/Flt4 have important roles in vasculogenesis angiogenesis. We studied localization these proteins immunohistochemistry Western blotting PlGF serum, association with diabetes, pre-eclampsia, fetal restriction (FGR) alcohol syndrome (FAS). VEGFR-1 VEGFR-3...
Aortic stenosis (AS) is characterized by extensive remodelling of the valves, including infiltration inflammatory cells, extracellular matrix degradation, and fibrosis. The molecular mechanisms behind this adverse have remained obscure. In article, we study whether cathepsin G, an angiotensin II (Ang II)-forming elastolytic enzyme, contributes to progression AS.Stenotic aortic valves (n = 86) control 17) were analysed for transforming growth factor-beta1 (TGF-beta1), collagens I III with...
To investigate the possible role of elastolytic cathepsins S, K, and V their endogenous inhibitor cystatin C in adverse extracellular matrix remodeling stenotic aortic valves.Stenotic valves were collected at valve replacement surgery control cardiac transplantations. The expression was studied by conventional real-time polymerase chain reaction immunohistochemistry. Total cathepsin activity quantified a fluorometric microassay. When compared with valves, showed increased mRNA (P<0.05 for...
Common reporting styles for statistical results in scientific articles, such as <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</i> -values and confidence intervals (CI), have been reported to be prone dichotomous interpretations, especially with respect the null hypothesis significance testing framework. For example when -value is small enough or CIs of mean effects a studied drug placebo are not overlapping, scientists tend claim significant...
Parental leave uptake by fathers represents one pathway to redress the typically unequal division of early childcare. Following Nordic schema, Finnish system is designed around this concept encourage uptake, but a substantial share refrain from it. Though there body literature on policy and individual-level motivators decision take often occurs in context workplace. Workplace factors are cited as typical barriers uptake. We systematically investigated how most important workplace...
To examine the proangiogenic potential of myofibroblasts and mast cells, 2 types cells present in human aortic valves.
Sequence analysis is being more and widely used for the of social sequences other multivariate categorical time series data. However, it often complex to describe, visualize, compare large sequence data, especially when there are multiple parallel per subject. Hidden (latent) Markov models (HMMs) able detect underlying latent structures they can be in various longitudinal settings: account measurement error, unobservable states, or compress information across several types observations....
The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation LDL-derived cholesterol in diseased valves. Since LDL particles also contain plant sterols, we investigated whether sterols accumulate lesions. Serum samples were collected from 82 patients with severe AS and 12 control subjects. Aortic valves obtained a subpopulation 21 undergoing surgery 10 controls. valvular total noncholesterol measured gas-liquid chromatography. Noncholesterol including both precursors...
AimsIn aortic stenosis (AS), adverse remodelling of the valves may depend on altered local regulation pro- and antifibrotic systems. We have recently shown that angiotensin-converting enzyme (ACE), which generates profibrotic angiotensin II inactivates bradykinin (BK), is upregulated in stenotic valves. Here, we analyse expression neutral endopeptidase (NEP), another BK-degrading enzyme, BK receptors AS.
The life history calendar is a data-collection tool for obtaining reliable retrospective data about events. To illustrate the analysis of such data, we compare model-based probabilistic event and model-free mining method, sequence analysis. In analysis, estimate instead transition hazards cumulative prediction probabilities events in entire trajectory. several dissimilarity metrics contrast data-driven user-defined substitution costs. As an example, study young adults' to adulthood as three...
Abstract Background We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE -/- ) mice, and putative effect on valves could be prevented by inhibiting angiotensin-converting enzyme (ACE) with enalapril. Methods Thickening apoE mice was induced producing mild or moderate chronic failure resulting from unilateral nephrectomy (1/2 NX, n = 18) subtotal (5/6 22), respectively. Additionally, 5/6 NX were randomized to no...