A5058871263- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Peripheral Artery Disease Management
- Dermatologic Treatments and Research
- Entomological Studies and Ecology
- Vitamin C and Antioxidants Research
- Central Venous Catheters and Hemodialysis
- Lymphatic System and Diseases
- Iron Metabolism and Disorders
- Genital Health and Disease
- Wound Healing and Treatments
- Orthodontics and Dentofacial Orthopedics
- Cynara cardunculus studies
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
- Cleft Lip and Palate Research
- COVID-19 Clinical Research Studies
- Acne and Rosacea Treatments and Effects
- Antioxidant Activity and Oxidative Stress
- Systemic Sclerosis and Related Diseases
- Chemotherapy-related skin toxicity
- Bone health and osteoporosis research
- Botulinum Toxin and Related Neurological Disorders
- Magnolia and Illicium research
University of Ferrara
2005-2025
Istituto Neurologico Mediterraneo
2022
Sapienza University of Rome
2006-2017
International Flame Research Foundation
2017
University of Cagliari
1995
Chronic venous disease (CVD) involves complex pathophysiological processes where the imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of (TIMPs) contributes to remodelling varicosities. Elevated levels MMP-2 MMP-9 are notably observed in tissues affected by ulcers. Local inflammation is a key feature CVD, with increased concentrations pro-inflammatory markers varicose veins compared healthy veins. Syndecans, components endothelial glycocalyx, play critical roles...
Chronic venous disease (CVD) involves complex pathophysiological mechanisms, particularly an imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), contributing to remodeling varicosities. Elevated MMP-2 MMP-9 levels are commonly found in tissues affected by ulcers. Inflammation plays a central role CVD, with higher of pro-inflammatory markers present varicose veins compared healthy ones. Syndecans, key components the endothelial glycocalyx, involved...
Background. Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway one of the recognized mechanisms MMP Objective. To investigate potential consequences leg deposits on iron metabolism activation MMPs. Methods. We contemporaneously assessed following in serum arm ankle veins 30 patients (C4–6) with CVD 14 normal subjects: ferritin, transferrin, iron, percentage transferrin...
Low Factor XIII (FXIII) activity has been reported in the blood of patients with chronic venous leg ulcer (CVU). In vivo studies have described increased wound healing CVU treated FXIII concentrate, and vitro shown regenerative capacity FXIII‐treated fibroblasts. addition, a common G‐to‐T polymorphism FXIIIA‐subunit gene (V34L) significantly increases modifies cross‐linking properties molecule this variant investigated as protective factor against thrombosis, recognized risk for...
Background Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway one of the recognized mechanisms MMP Objective To investigate potential consequences leg deposits on iron metabolism activation MMPs. Methods We contemporaneously assessed following in serum arm ankle veins 30 patients (C4–6) with CVD 14 normal subjects: ferritin, transferrin, iron, percentage transferrin binding...
Chronic venous disease (CVD) is an often underestimated inflammatory pathological condition that can have a serious impact on quality of life. Many therapies been proposed to deal with CVD, but unfortunately the symptoms recur increasing frequency and intensity as soon treatments are stopped. Previous studies shown common transcription factor AP-1 (activator protein-1) nuclear kappa-activated B-cell light chain enhancer (NF-kB) play key roles in initiation progression this vascular...
Sclerosing agents (SA) are blood inactivated. Nevertheless, investigations concerning the interaction among SA and components have never been deeply investigated. Aim of study is to precisely identify ligands, determine their binding time highlight clinical consequences. Thirty-one samples were collected from chronic venous disease patients tested by capillary agarose gel (AGE) electrophoresis before after adding polidocanol (POL) sodiumtetradecylsulphate (STS). The two different types...
An unavoidable consequence of the aerobic mechanism is production super-oxides and peroxides known as "Reactive Oxygen Species" (ROSs). These substances can trigger a number biological reactions not particularly dangerous at physiological concentration. However, in presence iron such greatly enhance radicals and, particular, determine release strongly reactive toxic hydroxyl radical (OH.). Many chronic inflammatory conditions share this underlying disequilibrium induced radical-antiradical...
Under physiological conditions, extracellular iron circulates in the blood bound to transferrin. As a consequence of several pathologies, circulating level Non-Transferrin Bound pool Iron (NTBI) increases. The NTBI is biologically heterogeneous and represented by chelated either small metabolites (citrate, amino acids, or cofactors) serum proteins. By promoting reactive oxygen species (ROS) nitrogen (RNS) formation, causes oxidative stress alteration membrane lipids, seriously compromising...
This work is the second part of a review on role free iron forms in cardiovascular diseases. Here, we stress various aspects related to form that are poorly chelated biocarriers, as for example NTBI (Non Transferrin Bound Iron). We report problems relating determination such and, after all, their implications cardiac diseases well venous insufficiency.
The role of the interstitial matrix in regulating exchanges and interactions at level microvascular units, between corpuscular component vascular nerve structures, has long been known. Equally known are objective subjective clinical manifestations that these pathologies trigger patient, both primary secondary forms: embarrassment, asthenia, alterations exteroceptive proprioceptive sensitivity, pain, reduced capacity, functional autonomy, affecting lower upper limbs. authors studied 136...
The onset of bruising in surgery is a frequent event that can be source complications and delays the patient's healing process (pigmentations, fibrosis, etc.). Having help an effective topical product speeds up resorption blood extravasation advantage phlebological general.Twenty-three patients both male female (age range: 30-72 years) were enrolled. Twenty-two them completed study, all underwent venous lower extremities (invagination stripping internal or external saphenous Muller's...
The aims of this study were to assess extemporaneous in vivo binding between 99mTcO4- and two sclerosant detergents foam sclerotherapy, subsequently control any possible damage lungs other organs related passage. A prospective comparative pilot was performed on male patients (62 56 years old) affected by varicose veins; each them underwent scintigraphy investigations with free radiotracer a investigation after the four sessions sclerotherapy tributaries lower limbs labeled foam. One further...
On late December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) causing severe pneumonia (COVID-19) was reported in Wuhan, Hubei Province, China and then all around the world. Data suggest that lung-centric systemic coagulopathy may play important role. Elevated D-dimer levels which correlated inversely with overall survival were recently Chinese studies. Critically however, COVID-19 infection is associated significant correlates disease severity 3-4-fold higher mortality risk....