A5079865178- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Neonatal skin health care
- Dermatology and Skin Diseases
- Gut microbiota and health
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical practice guidelines implementation
- Pharmaceutical studies and practices
- Radiation Dose and Imaging
The University of Melbourne
2006-2025
Murdoch Children's Research Institute
2021-2025
Australian Food Allergy Foundation
2021
Abstract Background Metagenome-assembled genomes have greatly expanded the reference for skin microbiome. However, current are largely based on samples from adults in North America and lack representation infants individuals other continents. Results Here we use deep shotgun metagenomic sequencing to profile microbiota of 215 at age 2–3 months 12 who part VITALITY trial Australia as well 67 maternally matched samples. Based infant samples, present Early-Life Skin Genomes (ELSG) catalog,...
Abstract Background Measurement of cashew‐specific IgE (sIgE) is often used to confirm sensitization but does not reliably diagnose clinical allergy. Ana o 3 the dominant cashew allergen detected in 75–100% patients with allergy currently practice. Objectives To determine if component‐resolved diagnostics using specific 2 S albumin from cashew, 3, improves accuracy diagnosing allergy, thereby circumventing need for an oral food challenge (OFC) some patients. Methods A population‐based sample...
Abstract Background Australia has one of the highest prevalence childhood food allergy in world, but there are no data on its economic burden Australia. Methods We used from HealthNuts study, a population‐based longitudinal study undertaken Melbourne, Infants were recruited at age 12 months between Sept 2007 and Aug 2011 with diagnosed using oral challenges. Health care costs out‐of‐hospital services collected through linkage to Australia's universal health insurance scheme Medicare....
In the absence of a clear clinical history reaction, diagnosis cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires high number oral food challenges (OFC). By Ana o 3 sIgE alone, two-step diagnostic algorithm followed by sIgE, there is reduced need for OFC. We aimed to perform cost comparison both these approaches compared with SPT alone.Pooled individual-level data from 6 studies were used determine accuracy and OFC rate. Two (n = 567, 198 allergic), 95% positive...
Background: In the absence of a clear clinical history reaction, diagnosis cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires high number oral food challenges (OFC). We recently showed that Ana o 3 sIgE alone, two-step diagnostic algorithm followed by can reduce need for OFC. aimed to determine if either these approaches provide cost reduction health system compared SPT alone. Methods: Pooled individual level data from 6 studies was used accuracy and OFC rate. Two...
Background: Peanut allergy prevalence is reported at 3% and consumes a significant volume of oral food challenges (OFC) in the diagnosis allergy. Compared to skin prick test (SPT) or sIgE whole peanut, peanut component ara h 2 has greater diagnostic accuracy. Two-step algorithms involving both SPT demonstrate increased accuracy modelled studies, resulting fewer OFCs. We aimed determine whether there similar reduction OFCs clinical uptake this two-step algorithm compared using alone perform...
Abstract Objective: Several guidelines have been developed to direct the ordering of head computed tomography (CT) for patients, but most are clinical presentation‐specific. Recently, an integrated guideline emergent CT patients who present ED Western Hospital, Footscray, Victoria, Australia, was in response concerns raised regarding perceived over‐utilization patients. Our aim determine compliance with guideline. Methods This explicit retrospective medical record review presented Hospital...
Background: In the absence of a clear clinical history reaction, diagnosis cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires high number oral food challenges (OFC). By Ana o 3 sIgE alone, two-step diagnostic algorithm followed by sIgE, there is reduced need for OFC. We aimed to perform cost comparison both these approaches compared SPT alone. Methods: Pooled individual level data from 6 studies was used determine accuracy and OFC rate. Two (n=567, 198 allergic),...