A5031516291- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Hemoglobinopathies and Related Disorders
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Reproductive System and Pregnancy
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Glutathione Transferases and Polymorphisms
- Cancer-related Molecular Pathways
- Celiac Disease Research and Management
- NF-κB Signaling Pathways
- Endometrial and Cervical Cancer Treatments
Institut Salah-Azaïz
2011-2024
Tunis El Manar University
2019-2024
Faculté de médecine de Tunis
2020-2023
Tunis University
2019-2023
Cancer Institute (WIA)
2015
Inserm
2008
Hôpital Saint-Louis
2008
Assistance Publique – Hôpitaux de Paris
2008
The interleukin 12 (IL‐12) cytokine, encoded by polymorphic genes, plays a central role in the T helper 1 cell‐mediated immunity against tumors. We investigated whether 3′ untranslated region +1188 A/C polymorphism (rs 3212227) influences nasopharyngeal carcinoma (NPC) risk Tunisian patients. DNA analysis of 247 patients and 284 healthy individuals showed higher frequency 1188 C allele CC genotype than controls ( P = 0.00001and 0.00005) suggesting that variant is associated with...
Human leukocyte antigens G and E (HLA-G HLA-E) are nonclassical major histocompatibility complex (MHC) class I molecules. These molecules play an important role in immune surveillance by inhibiting natural killer cytotoxic T cells responsible for escape. The expression of HLA-G HLA-E has been associated with several diseases including tumor. main objective the study is to evaluate impact three 3ʹUTR potential polymorphisms: +3187 A > (rs9380142), +3142 C (rs1063320), +2960 14-base pair (bp)...
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role NOS3, NOS2 GST polymorphisms in NPC risk Tunisians. found that NOS3−786C allele −786 CC genotype, NOS3+894T +894 GT+TT genotypes, NOS2−277 G −277 GG GSTT1 del/del are more prevalent patients as...
Target therapy for metastatic colorectal cancer needs the determination of KRAS, NRAS, and BRAF mutation status to identify patients resistant anti-EGFR treatment. RAS genes (KRAS/NRAS) are mutated in 40–60% 5–10%. The presence a double is rare. Therefore, mutations were considered exclusive. Herein, we describe novel concomitant NRAS/BRAF identified series 865 patients.
The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. part from its genetic diversity, MICA characterized by presence of membrane-bound and soluble isoform (sMICA) propensity to elicit antibody-mediated allogeneicity (MICA Abs). Altogether such properties are important in cancer setting. Here, we investigated whether polymorphism, serum level sMICA antibodies (Abs) may influence nasopharyngeal carcinoma (NPC) risk. 274 NPC...
Abstract Identification of candidate genes associated with susceptibility breast cancer can have a significant impact at management national healthcare systems level, making genetic testing more affordable and cost‐effective. We previously shown that the major histocompatibility complex class I‐related chain A (MICA) was related to plays an important role in modulating immune response mechanisms through NKG2D receptor activation. Compared our previous study, this work, we recruited new...
DNA hypomethylation of long interspersed repetitive retrotransposon (LINE‑1) and Alu repeats elements short family (SINEs) is an early event in carcinogenesis that causes transcriptional activation leads to chromosomal instability. In the current study, methylation levels LINE‑1 were analyzed tumoral tissues invasive breast cancer a Tunisian cohort its association with clinicopathological features patients was defined. using pyrosequencing 61 cancers. Median values observed for considered as...
Introduction: The Toll-like receptor 4 (TLR4), an important member of the host's innate immune response, is coded by a polymorphic gene. This polymorphism could be predisposing factor for NasoPharyngeal Carcinoma (NPC). Aim: To determine association between TLR4 gene polymorphisms and susceptibility to NPC in cohort Tunisian affected patients. Methods: Genomic DNAs from 245 unrelated patients undifferentiated carcinoma type (UCNT) 264 healthy controls were genotyped five single nucleotides...
<ns3:p><ns3:bold>Background: </ns3:bold>The PD-1/PD-L1 inhibitory immune checkpoint seems to have a significant prognostic impact in the evolution of certain cancers such as bronchopulmonary cancer, breast lymphomas etc. Indeed, it has been suggested that PD-L1 expression was associated with worse prognosis due its immunosuppressive activity within tumor tissue. Currently, evaluation these biomarkers is increasing interest gynecological cancers. Hence, we proposed study PDL1 vulvar cancer....
Objective: Coronary artery disease is the major cause of mortality in our country with 30% morbidity risks. Although rupture plaque mediated by many effectors, little known about metalloproteases role and regulation. Our objective was to study plasmatic variations MMP-9and its inhibitor TIMP-1 patients coronary disease, also influence 1562 C/T polymorphism promoter region MMP9 gene these patients. Design method: effectuated a population 131 controls 218 required cardiology service Rabta...