A5037362362- MicroRNA in disease regulation
- Machine Learning in Materials Science
- Invertebrate Immune Response Mechanisms
- X-ray Diffraction in Crystallography
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- Advanced Materials Characterization Techniques
- Regulation of Appetite and Obesity
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- Extracellular vesicles in disease
- HER2/EGFR in Cancer Research
Fudan University
2025
Bengbu Medical College
2022
Zhejiang University
2016-2020
Qingdao National Laboratory for Marine Science and Technology
2017-2018
Huazhong Agricultural University
2012-2016
Resistin, an adipokine involved in insulin resistance (IR) and diabetes, has recently been reported to play a role cardiovascular events. However, its effect on blood pressure (BP) the underlying mechanisms remain unclear. In present study, we showed that resistin induces hypertension IR wild type (WT) mice, but not tlr4(-/-) mice. Resistin upregulated angiotensinogen (Agt) expression WT whereas it had no or mice treated with angiotensin-converting enzyme inhibitor perindopril. Real-time PCR...
Obesity is associated with many severe chronic diseases and deciphering its development molecular mechanisms necessary for promoting treatment. Previous studies have revealed that mitochondrial content down-regulated in obesity, diabetes, nonalcoholic fatty liver disease (NAFLD) proposed NAFLD diabetes are diseases. However, the exact underlying these processes remain unclear. In this study, we discovered resistin activities of mitochondria, enhanced hepatic steatosis, induced insulin...
Growing evidence has indicated that the innate immune system can be regulated by microRNAs (miRNAs). However, mechanism underlying miRNA-mediated simultaneous activation of multiple pathways remains unknown. To address this issue, role host miR-12 in shrimp (Marsupenaeus japonicus) antiviral responses was characterized present study. The results participated virus infection, phagocytosis and apoptosis defense against white spot syndrome (WSSV) invasion. MiR-12 could simultaneously trigger...
Accelerating the discovery of novel crystal materials by machine learning is crucial for advancing various technologies from clean energy to information processing. The machine-learning models prediction properties require embedding atomic information, while traditional methods have limited effectiveness in enhancing accuracy. Here, we proposed an strategy called universal embeddings (UAEs) their broad applicability as fingerprints, and generated UAE tensors based on CrystalTransformer...
Melanoma is a type of aggressive skin cancer with poor survival rate. The resistance to conventional therapy this disease is, at least in part, attributed its stem cell population. However, the mechanism and stemness maintenance cells remains be investigated.Tumorsphere formation assay was used study stem-like property melanoma (MSLC). Chromatin immunoprecipitation (ChIP), promoter luciferase reporter were included for exploring role MCL-1 MSLC electrophoretic mobility shift evaluate...
The combination of deep learning algorithm and materials science has made significant progress in predicting novel understanding various behaviours materials. Here, we introduced a new model called as the Crystal Transformer Graph Neural Network (CTGNN), which combines advantages graph neural networks to address complexity structure-properties relation material data. Compared state-of-the-art models, CTGNN incorporates network structure for capturing local atomic interactions...
The dysregulation of microRNAs (miRNAs), key posttranscriptional regulators gene expression, is closely associated with cancer development. However, the miRNAs monocytes, important cells tumour immunity, have not been extensively explored. In present study, differentially expressed blood monocytes derived from gastric and breast patients healthy donors were characterized. results indicated that 74 upregulated 46 downregulated in or cancers compared donors, suggesting these 120 transformed...
The CIDEC protein is located in lipid droplets ( LD s) and the endoplasmic reticulum ER ) induced fat deposition. However, binding domain, functional domain underlying mechanism of stimulating accumulation remain unclear. Here, we investigated subcellular localization function pig confirmed promotes unilocular development s, reduces specific surface area SSA s stimulates HepG2 cells. By analyzing a series mutants, showed N‐domain (1–173 amino acid) involved C‐domain (174–238 necessary for...
In this work, we propose a novel approach to generate universal atomic embeddings, significantly enhancing the representational and accuracy aspects of which ultimately improves property prediction. Moreover, demonstrate excellent transferability embeddings across different databases various tasks. Our centers on developing CrystalTransformer model. Unlike traditional methods, model does not possess fundamental graph network architecture but utilizes Transformer extract latent features. This...