A5039062879- Heat shock proteins research
- Enzyme Structure and Function
- Endoplasmic Reticulum Stress and Disease
- Escherichia coli research studies
- Lung Cancer Research Studies
- Viral gastroenteritis research and epidemiology
- Cancer-related Molecular Pathways
- Vibrio bacteria research studies
- Mass Spectrometry Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Adipose Tissue and Metabolism
- Heat transfer and supercritical fluids
- Chromatin Remodeling and Cancer
- ATP Synthase and ATPases Research
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Effects of Radiation Exposure
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Protein Structure and Dynamics
- Ubiquitin and proteasome pathways
Center for Cancer Research
2022-2024
National Cancer Institute
2022-2024
National Institutes of Health
2024
University of Illinois Urbana-Champaign
2009-2016
South Dakota State University
2008
The androgen receptor is a key regulator of prostate cancer and the principal target current therapies collectively termed deprivation therapies. Insensitivity to these drugs hallmark progression terminal disease state castration-resistant cancer. Therefore, novel therapeutic options that slow combine effectively with existing agents are in urgent need. We show JG-98, an allosteric inhibitor HSP70, re-sensitizes by targeting mitochondrial HSP70 (HSPA9) suppress aerobic respiration. Rather...
Enterohemorrhagic Escherichia coli (EHEC) is a water- and food-borne pathogen that causes hemorrhagic colitis. EHEC uses type III secretion system (T3SS) to translocate effector proteins subvert host cell function. T3SS-substrates encoded outside of the locus enterocyte effacement are important E. pathogenesis. We discovered an secreted protein, NleF, by z6020 in O-island 71 EDL933 we hypothesized be T3SS substrate. Experiments presented probe function NleF its role virulence. Immunoblotting...
Abstract Objectives: Recent insights regarding mechanisms mediating stemness, heterogeneity, and metastatic potential of lung cancers have yet to be fully translated effective regimens for the treatment these malignancies. This study sought examine complex epigenetic underpinning aggressiveness SCLC, with a focus on understanding those stemness in highly lethal cancers. Methods: Normal small airway epithelial cells (SAECs) were reprogrammed into iPSCs, validated by various assays, such as...
The Second International Symposium on Cellular and Organismal Stress Responses took place virtually September 8–9, 2022. This meeting was supported by the Cell Society (CSSI) organized Patricija Van Oosten-Hawle Andrew Truman (University of North Carolina at Charlotte, USA) Mehdi Mollapour (SUNY Upstate Medical University, USA). goal this symposium to continue theme from initial in 2020 providing a platform for established researchers, new investigators, postdoctoral fellows, students...