Background and objectives Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are rapidly spreading, posing a serious threat to the health of people worldwide, resulting in World Health Organization officially declaring it pandemic. There several biochemical markers linked predicting severity disease. This study aims identify most effective predictive biomarker such as C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), procalcitonin (PCT), D-dimer,...

Background and Objectives: COVID-19 is a global pandemic. In our study, we aimed to utilize the hematological parameters in predicting prognosis mortality patients.Materials methods: A retrospective, observational study was conducted include all admitted patients (n = 191) having Polymerase chain reaction (PCR) positive, evaluated those for disease outcome by utilizing several biochemical markers.Results: Amongst ward versus intensive care unit (ICU), there were significant differences mean...

Health-care workers are on the front line to combat peculiar coronavirus disease-19 (COVID-19) pandemic and susceptible acquiring this infection. This study is aimed at documenting effect of "coronaphobia" mental well-being report burnout among physicians. The was conducted as a cross-sectional survey between November 17, 2020 January 1, 2021 via Google form distributed physicians tertiary care hospital, in Karachi, Pakistan. Warwick-Edinburgh Mental Well-being Scale (WEMWBS) used assess...

Modified radical mastectomy (MRM) is a standard surgical approach for breast cancer management. Conventional electrocautery and advanced vessel-sealing devices such as LigaSure Small Jaw are commonly used dissection hemostasis. However, their comparative efficacy regarding operative time, blood loss, outcomes remains an area of interest. Objective: To compare the conventional in patients undergoing modified mastectomy. Methodology: A prospective study was conducted Oncology Surgery...

Background Ankylosing spondylitis (AS) is a chronic rheumatological condition affecting sacroiliac joint and spine occurs more often in younger patients than the elderly population. Objective The purpose of study was to determine association neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) with disease activity AS. Methodology This case-control conducted rheumatology department at Pakistan Institute Medical Sciences (PIMS) hospital Islamabad from September 2018 July 2019....

Background and objectives Stone in the biliary tract is one of most common causes hospitalization. However, it difficult to determine prevalence gallstones general population because they are often asymptomatic. Thus, management lies proper clearance bile duct (CBD) along with removal gallbladder, for which must be diagnosed on time accuracy. Imaging modalities including magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasound (EUS), retrograde (ERCP) provide true...

Background and objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for disease 2019 (COVID-19) pandemic. The mainly affects system of patient, in particular, lungs, which leads to patients presenting with distress failure, 5-15% requiring observation intensive care unit (ICU) support form ventilation. This study was aimed at identifying role biochemical markers risk stratification invasive non-invasive ventilation hospitalized COVID-19...

Background and objectives Uremic pruritus is a recurrent delicate manifestation in patients suffering from end-stage renal disease. It consequence of multiple factors, primarily comprising metabolic factors complement activation along with interleukins. The objective our study was to find out the associated uremic chronic hemodialysis patients. secondary aim obtain cut-off values all markers predicting pruritus. Materials methods A cross-sectional observational conducted nephrology...

Acute appendicitis is one of most common indication for emergency surgery and it has a lifetime incidence 7 %. Characteristic presentation acute includes periumbilical pain, nausea, fever right lower quadrant pain tenderness. Appendectomy can be done open by Laparoscopy. Objective: To compare Appendiceal base leakage, mean duration surgery, post-operative hospital stay in extra corporeal knot tying suture versus metallic endo - clips laparoscopic stump closure patients with Methods: In this...

Background & Objectives: COVID-19 is a global pandemic, also affecting Pakistan with its first case reported on 26th February 2020. Since then, it has been total of 217,809 positive cases and 4473 deaths in so far. Deranged liver function enzymes levels are prominently detected extra-pulmonary clinical manifestation by at least one-half the patients. Our study aimed to evaluate these derangements our population. Methods: A retrospective, observational was conducted include all admitted...

BACKGROUND: Esophageal cancer ranks eighth among the most prevalent cancers globally and is sixth leading cause of mortality from malignancy worldwide; it 7th in males 6th females. In Pakistan, incidence 4.1 per 100 000 with province Baluchistan having greatest incidence. OBJECTIVE: Report trends characteristics esophageal Pakistan over past 10 years. DESIGN: Cross-sectional, retrospective review medical records. SETTING: Tertiary care hospital. PATIENTS AND METHODS: The study included all...

Background and objectives Sleep disorders are prevalent in end-stage renal disease (ESRD) involving the majority of patients undergoing hemodialysis. The main objective treating sleep ESRD is to correct subjective quality, decrease fatigue daytime sleepiness, enhance functioning. Irrespective adverse effects reported, benzodiazepines widely utilized among with disease. Melatonin a newer agent being studied for use hemodialysis improvement quality. aim our observational study witness...

Background and objectives Chronic liver disease (CLD) encompasses a variety of etiologies, the infectious causes are mainly hepatitis B C virus. alcohol abuse non-alcoholic fatty also have major contribution to CLD. The Child-Pugh scoring system indicates probable prognosis mortality risk patient with cirrhosis. primary objective this research is observe risks CLD caused by etiologies mentioned above. secondary determine biochemical markers that correlating severity study groups. Another aim...

Background and objective Juvenile idiopathic arthritis (JIA) is an autoimmune rheumatic disorder in children. JIA has been associated with depression a negative psychological impact on patients' quality of life. The aim the study to determine prevalence patients presenting at tertiary care hospital Islamabad, Pakistan. Materials methods This cross-sectional study, conducted Department Rheumatology, Pakistan Institute Medical Sciences, Pakistan, included 100 children aged >6 years who had...

Microscopic polyangiitis (MPA) is a primary systemic vasculitis characterized by inflammation of small-sized vessels associated with the presence anti-neutrophilic cytoplasmic antibodies. We report case 39-year-old female diagnosed microscopic as an incidental finding who presented signs and symptoms stroke at young age. Usually, it presents fever, malaise, skin rash, weight loss, mononeuritis multiplex, arthralgia/myalgia. Very rarely, can involve meninges to cause meningeal which present...

Purpose of the study: Outbreaks infectious diseases are known to have significant psychological effects not only on general population but health care workers as well. The COVID-19 pandemic also has been a challenge for Healthcare across globe when it comes their mental health. Study design: This is an observational cross-sectional study, carried out amongst frontline doctors units, by well-structured questionnaire using Google Forms. two scales used measure anxiety and depression among...

Background and objective The term asymptomatic bacteriuria (ASB) refers to the isolation of bacteria in a urine specimen individuals without any symptoms urinary tract infection (UTI). Diabetes mellitus (DM) is disease involving multiple organ systems, characterized by its chronicity hence endless complications including ASB. This study aimed determine characteristics ASB antibiotic susceptibility patterns among patients with diabetes. Materials methods was retrospective observational...

Viral hepatitis is a global phenomenon, with the disease burden varying on daily basis. Amongst chronic infections, B virus and C (HCV) are egregiously linked to severe health-related complications, worldwide prevalence of 248 million 71 respectively. developing world, hand full countries exhibiting gross decline in viral infection prevalence, like Bangladesh. While such as India have consistent Pakistan bears one largest proportions globally increasing trends shown year-by-year. Various old...

We present a case of sigmoid volvulus in young male patient with culture-proven Salmonella Typhi the blood which was sensitive to Meropenem and Azithromycin only, presented fever, vomiting, loose stools, hematochezia, abdominal distention tenderness no signs perforation on erect chest x-ray. Further, radiological imaging showed volvulus. An urgent colonic decompression untwisting mesentery performed. In our case, it can be said that developed as complication multiple drug-resistant strains...

Background and objectives Chronic kidney disease (CKD) share a common pathophysiology with non-alcoholic fatty liver (NAFLD). This study aims to identify the lipid derangements in patients of CKD associate them radiological evidence NAFLD. Material methods A cross-sectional observational was performed tertiary care hospital, include all chronic (n=238) through non-probability consecutive sampling. The criteria for inclusion were baseline estimated Glomerular filtration rate (eGFR) below 60...