A5100671908- Asthma and respiratory diseases
- Mast cells and histamine
- Menstrual Health and Disorders
- Biochemical effects in animals
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Immunotherapy and Biomarkers
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Click Chemistry and Applications
- Acupuncture Treatment Research Studies
- Long-Term Effects of COVID-19
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
Shenyang Medical College
2017-2024
University of Chinese Academy of Social Sciences
2024
Chinese Academy of Social Sciences
2024
Capital Medical University
2020-2023
Beijing Chao-Yang Hospital
2020-2023
Shandong Normal University
2023
Jinzhou Medical University
2014-2022
Lanzhou University
2020-2022
First Hospital of Lanzhou University
2020-2022
Tianjin Medical University
2006-2022
This study investigates the impact of marriage on body mass index (BMI) individuals aged 18-45 in China. We used data from ten rounds China Health and Nutrition Survey spanning 1989 to 2015, applied Difference-in-Differences (DID) model examine BMI. Our findings reveal that has a significant positive effect BMI, especially among males, with post-marriage elevation male BMI continuing increase over time. Moreover, is associated 5.2% prevalence overweight 2.5% rise incidence obesity males....
Tumor necrosis factor (TNF) is a proinflammatory cytokine which has been shown to be actively involved in the pathogenesis of allergic inflammation. However, little known effects TNF on secretion and protease activated receptor (PAR) expression mast cells. In present study, we examined potential influence IL-4 IL-12 release from P815 cells PAR by using flow cytometry analysis, quantitative real time PCR, ELISA cellular activation signaling (CASE) techniques. The results showed that induced...
Mast cells are primary effector of allergy, and recruitment mast in involved tissue is one the key events allergic inflammation. Tryptase most abundant secretory product cells, but little known its influence on cell accumulation. Using mouse peritoneal model, migration assay, flow cytometry analysis, we investigated role tryptase recruiting cells. The results showed that induced up to 6.7-fold increase numbers peritoneum following injection. Inhibitors tryptase, an antagonist PAR-2 FSLLRY-NH...
Abstract It is recognized that IL‐18 related to development of asthma, but role in asthma remains controversial and confusing. This largely due lack information on expression binding protein (BP) receptor (R) asthma. In this study, we found plasma levels IL‐18BP were elevated The ratio between concentrations was 1:12.8 patients. We demonstrated 13‐fold more monocytes, 17.5‐fold neutrophils 4.1‐fold B cells express than asthmatic blood, suggesting there excessive amount abolish actions also...
Human regulatory T (Treg) cells play a central role in controlling allergic inflammation the airways. A reduced number of peripheral Treg and decreased suppressive function have been previously reported pathogenesis asthma. However, characteristic specific cell subsets their mechanisms asthma remain unclear. In this study, we examined proportion different both healthy subjects patients with using flow cytometry single-cell RNA sequencing. The migration was compared sorting Transwell...
It has been recognized that protease‐activated receptors (PARs), interleukin (IL)‐4 and IL‐6 are involved in the pathogenesis of allergic diseases, IL‐12 plays a role adaptive immune response. However, little is known effect on protease‐induced cytokine release from mast cells. In present study, we examined potential influence cell PAR expression IL‐4 release. The results showed downregulated PAR‐2 upregulated PAR‐4 P815 also mRNA, PAR‐1, PAR‐3 mRNAs. enhanced trypsin‐ tryptase‐induced mRNA...
Abstract Backgroud Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported be able alter expression of TLRs cytokine production in neutrophils. However, whether GM-CSF modulates the TLR is not clear. Results Using flow cytometry real time PCR techniques, we found that upregulated TLR3 TLR7 P815 a concentration dependent manner. also provoked approximately up...
The present study aimed to investigate the therapeutic effect of Shu-Yu capsule (SYC), a Traditional Chinese Medicine formulation, on premenstrual syndrome (PMS) depression and ratio glutamate (Glu) γ-aminobutyric acid (GABA) in rat model PMS depression. Rats were randomly divided into control group, fluoxetine SYC group saikosaponins (SS) group. was evaluated using sucrose preference test (SPT), open field (OFT) body mass following four days treatment. Hippocampal extracellular fluid...
Introduction: Cutaneous adverse events are commonly reported immune-related (irAEs), some of which serious or even life-threatening, and it is essential to study these specific cutaneous AEs understand their characteristics risk. Methods: We performed a meta-analysis published clinical trials for immune checkpoint inhibitors (ICIs) evaluate the incidence events, using data from PubMed, Embase, Cochrane Library databases. Results: A total 232 with 45,472 patients were involved. Results showed...
Background: It has been reported that peptidoglycan (PGN) and lipopolysaccharide (LPS) can provoke mast cells to release an array of cytokines via TLR2 TLR4, respectively. However, little is known the regulatory mechanism TLR4 mediated cytokine production in cells. Methods: Since IL-12 plays important roles protection body from microorganism infection cell a crucial source IL-12, we investigated effects on expression by using quantitative real time PCR, flow cytometry analysis cellular...
Increased expression of substance P (SP) and neurokinin-1 receptor (NK1R) has been noticed in patients with allergic rhinitis (AR) asthma (AA). However, little is known the SP NK1R monocytes B cells AR AA. In present study, levels were determined by flow cytometry mouse AA models. The results showed that both percentages SP+ cells, mean fluorescence intensity (MFI) elevated blood combined (ARA) patients. Similarly, NK1R+ AR, AA, ARA Allergens Artemisia sieversiana wild allergen extract...
Abstract Background Large numbers of CD8 + T cells were observed in atopic dermatitis (AD) skin, and monocytes from AD patients showed increased prostaglandin E2 production. However, little is known about the expression substance P (SP) its receptor NK1R blood leukocytes with AD. Objective To explore SP influence allergens on expression. Methods The levels examined by flow cytometry, ELISA a mouse model. Results plasma level was 4.9-fold higher than HC subjects. Both percentage population...