A5061024025- Veterinary Equine Medical Research
- Reproductive Physiology in Livestock
- Neural dynamics and brain function
- Reproductive Biology and Fertility
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Blood Coagulation and Thrombosis Mechanisms
- Neuroendocrine regulation and behavior
- Ovarian function and disorders
- Neuropeptides and Animal Physiology
- Protease and Inhibitor Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Psychological and Temporal Perspectives Research
- Anesthesia and Neurotoxicity Research
- Spaceflight effects on biology
- Ion Channels and Receptors
- Effects of Environmental Stressors on Livestock
King's College London
2021-2022
Medical Research Council
2022
University of Surrey
2014-2020
University of Edinburgh
2001-2007
The Queen's Medical Research Institute
2007
Abstract The nuclear mineralocorticoid receptor (MR), a high‐affinity for glucocorticoids, is highly expressed in the hippocampus where it underpins cognitive, behavioural and neuroendocrine regulation. Increased neuronal MR expression occurs early response to cellular injury vivo vitro associated with enhanced survival. To determine whether increased might be causal protecting against ischaemic damage we generated forebrain‐specific MR‐overexpressing transgenic mouse (MR‐Tg) under control...
Significance Brain function requires appropriate numbers of different neuronal subtypes, but how these are established remains poorly understood. Here, we identified a key role for the cerebral cortex in remotely controlling interneuron survival and thus establishing two main types interneurons another brain region, striatum. While cortical pyramidal cells directly control parvalbumin-expressing GABAergic neurons, cholinergic is indirectly controlled through activity striatal medium spiny...
Melatonin receptor expression exhibits profound developmental changes through poorly understood mechanisms. In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin receptors in pituitary gonadotroph cells, via the induction early growth response factor-1 (EGR-1). Here we have examined this by testing hypotheses inhibition Mt1 GnRH occurs directly can be reversed adulthood blockade receptors, and requires...
Polymorphisms in human circadian clock gene PERIOD3 (PER3) are associated with a wide variety of phenotypes such as diurnal preference, delayed sleep phase disorder, homeostasis, cognitive performance, bipolar type 2 diabetes, cardiac regulation, cancer, light sensitivity, hormone and cytokine secretion, addiction. However, the molecular mechanisms underlying these phenotypic associations remain unknown. Per3 knockout mice (Per3-/-) have related to activity, anhedonia, metabolism,...
We have previously reported that neuronal endangerment in vitro and hypothermic transient global ischaemia vivo each result increased mineralocorticoid receptor (MR) expression. In both models MR induction is associated with survival, blocking signalling reduces survival. Furthermore, transgenic overexpression of human promotes survival vivo.Here we assessed whether brief periods cerebral subjects, such as occurs cardiac arrest from which successful resuscitation achieved, are a sustained...
The assembly of functional neuronal circuits requires appropriate numbers distinct classes neurons, but the mechanisms through which their relative proportions are established remain poorly defined. Investigating mouse striatum, here we found that two most prominent subtypes striatal interneurons, parvalbumin-expressing (PV+) GABAergic and cholinergic (ChAT+) undergo extensive programmed cell death between first second postnatal weeks. Remarkably, survival PV+ ChAT+ interneurons is regulated...