A5050334482- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- AI in cancer detection
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Protein Degradation and Inhibitors
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Multiple Myeloma Research and Treatments
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cytokine Signaling Pathways and Interactions
California Pacific Medical Center
2018-2023
Abstract Cholangiocarcinoma (CCA) is a highly invasive cancer, diagnosed at an advanced stage, and refractory to surgical intervention chemotherapy. Cyclin-dependent kinases (CDKs) regulate cell cycle progression transcriptional processes, are considered potential therapeutic targets for cancer. Dinaciclib small molecule multi-CDK inhibitor targeting CDK 2/5/9. In this study, the efficacy of dinaciclib was assessed using patient-derived xenograft cells (PDXC) CCA lines. Treatment with...
Glioblastoma’s (GBM) aggressive growth is driven by redundant activation of a myriad signaling pathways and genomic alterations in tyrosine kinase receptors, such as epidermal factor receptor (EGFR), which altered over 50% cases. Single agents targeting EGFR have not proven effective against GBM. In this study, we aimed to identify an anti-tumor regimen using pharmacogenomic testing patient-derived GBM samples, culture vivo. High-throughput pharmacological screens ten EGFR-driven samples...
Therapy of
Purpose: Previous studies have indicated an important role for pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. Here we aimed to confirm the PHIP copy number in successive stages progression.Experimental Design:PHIP was examined using FISH three independent cohorts by recording percentage cells harboring ≥3 copies The impact on survival assessed Cox regression analysis. enrichment various molecular subtypes. expression analyzed Cancer...
Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells which are abundantly present in lymph nodes. We want to examine drainage patterns of Tilmanocept sentinel nodes (SLNs) melanoma patients following 10% rule.Multi-center retrospective review with cutaneous undergoing SLN biopsy using between 2008 2014 was conducted. Statistical methods were used for data analyses.Of 564 (mean age 60.3 62% male)...
<p>Contains Supplementary Table 1, and Figure 1 2</p>
<div>Abstract<p><b>Purpose:</b> Previous studies have indicated an important role for pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. Here we aimed to confirm the <i>PHIP</i> copy number in successive stages progression.</p><p><b>Experimental Design:</b> was examined using FISH three independent cohorts by recording percentage cells harboring ≥3 copies <i>PHIP</i>....
<p>Contains Supplementary Table 1, and Figure 1 2</p>
<div>Abstract<p><b>Purpose:</b> Previous studies have indicated an important role for pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. Here we aimed to confirm the <i>PHIP</i> copy number in successive stages progression.</p><p><b>Experimental Design:</b> was examined using FISH three independent cohorts by recording percentage cells harboring ≥3 copies <i>PHIP</i>....