A5000072777- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Pituitary Gland Disorders and Treatments
- Otolaryngology and Infectious Diseases
- Airway Management and Intubation Techniques
- Olfactory and Sensory Function Studies
- Dysphagia Assessment and Management
- Meningioma and schwannoma management
- RNA regulation and disease
- Voice and Speech Disorders
- RNA modifications and cancer
- Thyroid and Parathyroid Surgery
- Advanced Chemical Sensor Technologies
- Calpain Protease Function and Regulation
- Esophageal and GI Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Restraint-Related Deaths
Hospital Universitario Virgen Macarena
2016-2025
Instituto de Biomedicina de Sevilla
2023-2024
Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
2023-2024
Universidad de Sevilla
2023-2024
Hospital Universitario Virgen del Rocío
2007-2024
International University of Andalucía
2024
Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number studies have reported on smell and/or taste dysfunction (STD). Objective: The aim our study was to investigate frequency and severity STD in COVID-19 patients evaluate association with demographic characteristics, hospital admission, symptoms, comorbidities, blood biomarkers.We performed multicenter cross-sectional who were positive for SARS-CoV-2 (n=846) controls (n=143) 15 Spanish...
The COVID-19 outbreak has spread extensively around the world. Loss of smell and taste have emerged as main predictors for COVID-19. objective our study is to develop a comprehensive machine learning (ML) modelling framework assess predictive value disorders, along with other symptoms, in infection. A multicenter case-control was performed, which suspected cases COVID-19, who were tested by real-time reverse-transcription polymerase chain reaction (RT-PCR), informed about presence severity...
(1) Background: Surgical criteria for chronic rhinosinusitis with nasal polyps (CRSwNP) remain unresolved. This study addresses these discrepancies by comparing the clinical outcomes of expanded-functional endoscopic sinus surgeries (E-FESS) more-limited FESS (L-FESS). (2) Methods: A database was analyzed retrospectively to compare surgical in CRSwNP patients who underwent E-FESS versus those subjected L-FESS. Quality life, and radiological were compared at baseline two years after surgery....
Introduction: The worldwide incidence rate of laryngeal cancer is declining. However, the 5-year survival for these patients has decreased in recent years from 66% to 63%. This may be due changes treatment disease. present study aimed evaluate with LC according stage disease and applied. For this purpose, surgical versus organ preservation protocols (OPP) based on chemoradiotherapy were evaluated. Methods: A retrospective cohort was conducted a tertiary hospital. included adult clinical...
Key points Expanded types of functional endoscopic sinus surgery (FESS) significantly improve quality life and reduce revision surgeries rates, supporting their early application for moderate‐to‐severe cases. Minimal clinically important difference may play as a crucial role in defining surgical treatment response (i.e., responder super‐responder conditions). FESS benefits patients with chronic rhinosinusitis nasal polyps but more data are required to have clearer understanding its uses due...
Although extended endoscopic sinus surgery (ESS) constitutes an alternative approach in patients with Chronic Rhinosinusitis Nasal Polyps (CRSwNP), the surgical techniques proposed so far do not allow for optimal control of disease. This study introduces bilateral mucoplasty as a complementary technique to ESS such reboot surgery, analyzing its benefits healing and quality life (QoL).Patients diagnosed severe Type-2 CRSwNP were selected prospective cohort two groups: plus versus only. In...
Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction still poorly understood.102 out 421 (24.2%) mildly symptomatic patients completed a second questionnaire about evolution their one year after infection using visual analog scales (VAS). A subgroup 69 also underwent psychophysical evaluation olfactory function through UPSIT.The prevalence decreased from 82.4% 45.1% 12 months, with...
Fibroblasts and others mesenchymal cells have recently been identified as critical triggering tissue-specific inflammatory responses. Persistent activation of fibroblasts program has suggested an underlying cause chronic inflammation in a wide range tissues pathologies. Nevertheless, the role emergence upper airway not previously addressed. We aimed to elucidate whether could response rhinosinusitis with nasal polyps (CRSwNP).We performed whole-transcriptome microarray fibroblast cultured...
We report a novel surgical technique based on an endonasal free mucosal graft (mucoplasty) for improving clinical results and local healing in chronic rhinosinusitis with nasal polyps (CRSwNP).Patients diagnosed bilateral CRSwNP scheduled endoscopic sinus surgery were included. They underwent complete removal of anterior posterior ethmoid cells, addition to type III frontal sinusotomy. An mucoplasty was performed the left cavity, whereas right cavity served as control. Patients evaluated...
Tissue-specific Activated Regulatory Lymphocytes Immunophenotype in Chronic Rhinosinusitis with Nasal PolypsTo the Director, rhinosinusitis nasal polyposis (CRSwNP) is a chronic inflammatory disease that affects about 5% of general global population. 1 It constitutes major health problem significant comorbidities and high socioeconomic healthcare costs. 2 Some co-existing medical conditions (such as moderate or severe asthma, aspirin-exacerbated respiratory (AERD), allergic rhinitis) are...
Abstract Background Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+‐dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 ( CAPN10 ) haplotypes laryngeal has been found recently. Therefore, the goal of this study was to analyze contribution alleles survival. Methods Patients were recruited from southern Spain. Genotypes determined using...
Currently, some monoclonal antibodies (mAbs) are being studied for chronic rhinosinusitis with nasal polyps (CRSwNP). Three anti-IL-5 mAb: mepolizumab, reslizumab and benralizumab, have been tested through randomized clinical trials. In this real-life study, we aimed to describe the effects of a cohort asthmatic adults treated mAb. Methods: We carried out an observational study in (≥18 years) on mAb treatment. Variables included ACT SNOT−22 questionnaires, score, blood total IgE levels...
Abstract Objectives To perform a radio‐anatomical evaluation of the nasal cavity floor free mucosal graft (endonasal extended mucoplasty, EEM) to repair defects after an ethmoid‐sphenoidotomy. Methods A human cadaveric study (radiological and anatomical dissection) in vivo surgical patients with CRSwNP were performed. The EEM areas compared between 3D reconstruction from CT scans anatomical/surgical dissections, both cadaver specimens patients. Feasibility was assessed by correlation area on...